静脉色氨酸耐量试验在病毒性肝炎患者中的应用

APPLICATION OF INTRAVENOUS TRYPTOPHAN TOLERANCE TEST TO PATIENTS WITH VIRAL HEPATITIS

作者对9l例病毒性肝炎患者进行静脉色氨酸耐量试验,结果显示慢性活动性肝炎(CAH)组总色氨酸(T45)为107.5±18.9,慢性迁延性肝炎(CPH)及急性肝炎(AH)组分别为108.0±15.4、97.O±14.6μmol/L,均高于正常人组,但三组间无显著差异;重型肝炎组与正常人组相似.游离色氨酸(F15)在重型肝炎组为18.9±8.1,CAH组9.1±2.4,CPH组与AH组分别为7.2±2.2及7.2±1.6 μmol/L.CPH与AH恢复期T455下降,而CAH恢复期F46不下降,且T46升高的程度与肝脏损害的严重程度一致,故可认为T45升高是肝脏损害的标志.

Intravenous tryptophan tolerance test was applied to 91 patients with viral hepatitis.The serum toltal tryptophan 45 minutes(T45)after iv administration was 107.5±18.9μmol/L in 43 cases wish chronic active hepatitis(CAH),108.0±15.4μmol/L in 17 chronic per-sistant hepatitis(GPH)and 97.0±14.6/μmol/L in 20 acule hepatitis(AH),which were higher than the normal controls(71.7±8.9μmol/L)(p<0.01).The values of T45 in 11 cases with evere hepatitis(SH)and normal subjects were similar.The values of free tryptophan 45minutes(F45)after iv administration were 18.9±8.1μmol/L in SH,9.1±2.4μmol/L in CAH,7.2±2.2μmol/L in OPH and 7.2±h1.6μmol/L in AH.The level of F45 decreased in convalescent stage of CPH and AH while it did not decrease in CAH.Furthermore,it was found that the degree of F45 elevation coincided with the severity of liver damage,thus the elevation Of F44 level could be considered as one of the markers of liver damage.