血清谷胱甘肽-S转移酶检测在肝脏疾病中的意义

CLINICAL SIGNIFICANCE OF SERUM GLUTATHONE S-TRANSFERASE MEASURE MENT IN LIVER DISEASES

本文报告了血清谷胱甘肽-S转移酶(GST)在健康者、肝脏疾病及非肝脏疾病患者的活性.健康人(200名)为13.6±5.8IU/L;急性肝炎(94例)、慢性活动性肝炎(26例)、重型肝炎(94例)、HBsAg 携带者(12例)及肝硬化患者(15例)分别为52.2±23.7、65.6±52.0、94.9±25.3、18.9±9.93及31.7±13.8IU/L,均显著高于健康人(P<0.01);非肝脏疾病患者(721例)为13.4±8.4 IU/L,与健康人无显著差异(P>0.05).结果表明GST是一项理想的肝功能指标,且在诊断慢性肝病中优于ALT;GST变化与肝脏病理改变具有一致性;观察GST及ALT变化有助于重型肝炎预后的判断.此外,GST活性的检测还有助于黄疽的鉴别诊断.

Serum glutathione S-transferase(GST)aciivity was measured in 94 cases of acute hepatitis,26 chronic active hepatitis,17 severe hepatitis,12 chronic HBsAg carriers and 17 liver cirrhosis.The levels were 52.2±23.7IU/L,65.5±52.OIU/L,94.9±25.8IU/L,18.9± 9.9IU/L and 31.7 13.8IU/L respectively.They were significantly higher in those patients than in the 200 healthy controls(13.6±5.8IU/L,P<O.01).GST activity was 13.4±8.4 IU/L in the 721 patients without liver diseases.which was not significantly different from those of healthy controls(P>0.05).In contrast to survival,GST activity was persistently increased in dead cases with severe hepatitis,and it appeared a GST/ALT dissociation.Although ALT had been normal in the convalesent stage of hepatitis patients,GST level in most of them remained high and various degrees of pathological.changes were present in liver biopsy.Thus our data suggest that GST activity measurement might be a more sensitive marker of liver damage than ALT,and it might be valuable in evaluating the prognosis of severe hepatitis and in differentiating the jaundice.