流行性出血热患者尿中抗体的检测及其意义

COMMENT ON THE DETECTION OF URINARY ANTIBODY IN EPIDEMIC HEMORRHAGIC FEVER

应用两种ELISA技术分别对流行性出血热(EHF)患者25例的203份屎液标本特异性IgG,IgM抗体进行了系统的动态研究,发现抗体阳性率分别为84%(21/25)与60%(15/25).而16%(4/25)的患者在整个病程中既无IgG又无IgM抗体排出,表明尿抗体检测阴性结果不能作为EHF患者排除诊断的条件,仅为参考指标.病程中IgG抗体平均滴度动态水平与每日标本阳性率均高于IgM,且两种抗体的动态变化与尿蛋白相符合,证实尿抗体是由于肾脏损害而漏出的结果.

A sequential study on the specific IgG and IgM,antibodies 203 urine specimens from 25 patients of epidemio hemorrhagic fever with renal syndrome Was performed by two kinds of ELISA techniques:The positive rates of IgG and IgM were 84%(21/25)and.60%(15/25)respectively,and 16% of the patients were negative.However,the negative result dose not imply the exclusion of the disease.We also found that the each-day samples'positive rates and mean titer of IgG were higher than IgM in the whole course of illness.It showed that they were leakages from the damaged kidneys