前S1和前S2蛋白-HBV复制的新标志

DETECTION OF PRE-S1 AND PRE-S2 PROTEINS: NEW MARKERS OF HBV REPLICATION

对63例乙型肝炎患者血清中前S1和前S2蛋白的研究表明,两者均与病毒的复制具有明显的相关性.41例前81蛋白阳性者中,HBeAg阳性为31例,占75.6%:45例前81蛋白阳性者中HBV白蛋白受体阳性为32例,占71.7%.35例前S2蛋白阳性者中,HBeAg阳性为27例,占77.1%;39例前S2蛋白阳性者中.HBV白蛋白受体阳性为30例,占77.0%.对前S1和前S2蛋白用HBV DNA,DNA-P的关系的研究也可得出相同的结论,以上结论表明前S1和前S2蛋白可以作为表达病毒活动性复制的新标志,并提示两者可能均涉及到病毒对肝细胞的附着过程.

The researches on HBV Pro-S1 and Pro-S2 proteins among 63 eases with chronic hepatitis B showed that the Pre-s gene products were closely correlated with the replication of virus.Among 41 Pre-Sl positive cases,31 eases were HBeAg positive(75.6%)and 32 of the 45 with Pre-S1 positive were PHSA-R positive.Similarly,among the 32 Pro-S2 positive cases,27 were HBeAg positive(77.1%)and 30 of the 32 Pre-S2 positive were PHSA-R positive.The present study also revealed tha there was positive correlation between Pre-S1 and Pro-S2 proteins and HBV DNA and DNA-p.These results suggested that the detection of Pre-S1 and Pro-S2 proteins could be used as the new markers of HBV replication.