乙基西梭霉素的评价

LABORATORY AND CLINICAL EVALUATION OF NETILMICIN

本文报道对乙基西梭霉素(NET)进行抗菌作用、正常人药代动力学和临床研究结果.本品对金葡菌等革兰氏阳性球菌(除肠球菌外)、肠杆菌科细菌和绿脓杆菌具较强抗菌活性,氨基糖类耐药菌株中部分对本品仍敏感.正常人肌注或静滴2mg/kg后血峰浓度分别为7.6±1.3mg/L和14.1±0.87mg/L,消除半衰期约为2h,24h内尿中排出85%.临床试用于各种感染50例,每日剂置3～6mg/kg,有效率90%,来见明显耳、肾毒性.对乙基西梭霉索的适应症和临床应用前景进行了探试 .

A study on miorobiology,elinioal pharmacology and olmical effioaey and safety of netilmioin (NET),a new aminoglycoside,was undertaken.NET has good activity against S.aureus,other Gram positive cocci(except enterococci),Entarobaoteriaoeae and Ps aeruginosa and part of the strains resistant to other aminoglycosides.After Jan injeotion or iv infusion of 2mg/kg of NET to normal volunteers.the peak blood conoentrations were 7.6±1.31m g/L and 14.1±0.87mg/L respeokively.The elimination half life of both im and iv routes was around 2h,85% of the administered doseexcleted in urine within 24h. NET was given in a daily dosage of 3～6mg/kg to 50 patients with various infections,the total effective rate being 90%,no obvious oto-or nephro-toxieity was noted. The clinical indieation and prospoct of its usage are discussed.