颗粒蛋白前体在生殖系统中的研究进展

Research progress of progranulin and related diseases of reproductive system

颗粒蛋白前体(PGRN)是一种新型的多功能自分泌生长因子,持续高表达于组织的塑形和重构过程,如胚胎的发育、伤口的修复、炎症及肿瘤组织的形成等。PGRN由于其在肿瘤的发生发展过程中的关键作用,目前已成为多种肿瘤研究的热点,而近年来,其在炎症及代谢疾病中的研究也逐步增加,PGRN广泛分布于生殖系统,在生殖系统疾病的发病中起着重要作用,本文就其在生殖系统中的分布,与生殖内分泌疾病的关系及其生殖系统肿瘤中的作用进行综述。

Progranulin (PGRN) is a secreted protein which plays a pivotal role in multiple physiological and pathological conditions, including embryogenesis, wound healing, tumorgenesis and inflammation response. It's a hotspot of research for its key role in the development of a tumor. In recent years, research of PGRN in inflammation and metabolic diseases gradually increased, PGRN is a multifunctional immunomodulatory molecule. PGRN is widely distributed in the reproductive system, plays an important role in the pathogenesis of diseases of the reproductive system. In this review, we discussed current knowledge of the functional aspects, the distribution in the reproductive system, reproductive system cancer and its relationship with reproductive endocrine disorders.