类风湿关节炎患者外周血及关节液中Treg细胞和Th17细胞水平的研究进展

Research progress of level of regulatory T cells and T helper cells 17 in peripheral blood and synovium of patients with rheumatoid arthritis

近年来,多种研究表明T淋巴细胞亚群在类风湿关节炎(RA)发病机制中具有重要作用。致病性辅助性T细胞17(Th17细胞)介导血管翳增生、破骨细胞生成及滑膜新生血管生成,因此它们是疾病进展的关键因素。另一方面,调节性T(Treg)细胞是具有抑制自身反应性淋巴细胞功能的一类T细胞亚群。Th17与Treg细胞的失衡被认为是RA发病机制中的关键。而关于RA患者外周血及关节液中Th17/Treg细胞水平的观察结果不一,本文就致病性Th17细胞和抑制性Treg细胞在RA患者外周血及关节液中的水平,结合近几年的研究成果作一综述。

In recent years several studies investigated the role of T lymphocyte subpopulations in the pathogenesis of rheumatoid arthritis (RA). Pathogenic T helper 17 (Th17) cells mediate pannus growth, osteoclastogenesis and synovial neoangiogenesis; hence they are key factors in the development of the disease. On the other hand, regulatory T (Treg) cells are T cell subset whose peculiar function is to suppress autoreactive lymphocytes. The imbalance between Th17 cells and Treg cells has been identified as a crucial event in the pathogenesis of RA. However, the observations of the level of Treg cells and Th17 cells in RA peripheral blood and synovium is contradictory. The paper critically discussed the current knowledge on Treg and Th17 cells in peripheral blood and synovium of patients with RA.