皮内注射牛痘疫苗致炎兔皮提取物治疗带状疱疹神经痛的疗效评价

Therapeutic evaluation of intradermal injection of inflamed rabbit skin inoculated with vaccinia virus in herpes zoster patients and incidence of postherpetic neuralgia

目的 评价皮内注射牛痘疫苗致炎兔皮提取物治疗带状疱疹及预防其后遗神经痛的效果.方法 急性期带状疱疹患者74例随机分为A(n =37),皮内注射牛痘疫苗致炎兔皮提取物+利多卡因)、B(n =37,皮内注射利多卡因)组.两组在治疗第11、22、30、60、90 d随访,比较两组疱疹及疼痛评价指标、带状疱疹后遗痛发生率、综合疗效的差异.结果 A组止疱时间、结痂时间、脱痂时间、治疗后疼痛强度、疼痛缓解时间均短于B组(P＜0.05).带状疱疹后遗神经痛发生率,A组在30天发生例数低于B组(P＜0.05),60 d、90 d差异无统计学意义(P＞0.05).A组(总有效率为91.9％)疗效优于B组(总有效率为64.9％).结论 牛痘疫苗致炎兔皮提取物皮内注射可缩短带状疱疹的病程,缓解疼痛程度,降低其后遗神经痛的发生.

Objective To investigate the clinical efficacy of intradermal injection of extract from rabbit skin inflamed by vaccinia virus in the treatment of herpes zoster and prevention of postherpetic neuralgia.Methods Thirty seven patients in group A were received intradermal injection of inflamed rabbit skin extracts inoculated with vaccinia virus and lidocaine,and thirty seven patients in group B were treated with intradermal injection of lidocaine.And the following indicators,including herpes evaluation index,pain intensity,postherpetic neuralgia incidence,and comprehensive therapeutic effect were compared between the two groups after 11,22,30 and 60 days follow-up.Results The time for ceasing new blister,blister incrustation and decrustation,pain relief and pain intensity in Group A were significantly superior to those in group B (P ＜ 0.05).And the incidence of postherpetic neuralgia in Group A was significantly lower than that of Group B at 30 days of follow-up (P ＜ 0.05).However,no significant difference was found between the two groups at 60 and 90 days of follow-up (all P ＜ 0.05).Overall,the total clinical effective rate of Group A (91.9 ％) was better than Group B (64.9 ％) (P ＜ 0.05).Conclusion The treatment of intradermal injection of extract from rabbit skin inflamed by vaccinia virus can effectively shorten the course of the disease,reduce the pain intensity and prevent the development of postherpetic neuralgia.