肠黏膜屏障功能障碍在重症急性胰腺炎中的研究进展

Progress of intestinal mucosal barrier dysfunction in severe acute pancreatitis

重症急性胰腺炎(SAP)病情险恶、并发症多,且病死率高。过去几十年来,SAP发病率显著增加,SAP可导致肠道黏膜屏障损伤,从而引起细菌或内毒素易位,继而出现胰腺组织继发感染,导致全身炎症反应综合征(SIRS)及多器官功能障碍综合征,进而影响SAP患者的预后。在SAP发病过程中肠黏膜屏障损伤具有重要作用。因此,对肠道黏膜屏障功能障碍在SAP发病机制研究中尤为重要。现将重症急性胰腺炎肠黏膜屏障功能障碍的研究进展进行综述。

Severe acute pancreatitis (SAP) is a severe disease, with many complications and high fatality rate. In the past few decades, the incidence rate of SAP increased signiifcantly, which could damage the intestinal mucosa barrier, lead to bacterial and endotoxin translocation, pancreatic tissue infection, and then systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome, eventually affects the prognosis of the patients. During SAP, intestinal mucosa barrier damage plays a key role. Therefore, the research of intestinal mucosal barrier dysfunction mechanism in SAP is important. The progress of intestinal mucosal barrier dysfunction in SAP were reviewed.