单用硫唑嘌呤或联用硫唑嘌呤及英夫利西单克隆抗体对克罗恩病术后复发的影响

Effect of azathioprine or combination of azathioprine and infliximab on postoperative recurrence of Crohn's disease

目的 研究单用硫唑嘌呤(AZA)或联用硫唑嘌呤及英夫利西单抗(IFX)对克罗恩病术后复发的影响,并分析患者术后复发的危险因素.方法 纳入南方医科大学南方医院行肠切除术的99例克罗恩病患者,根据术后预防用药的情况分为AZA组(25例)、IFX+AZA组(18例)和未用药组(56例).比较不同用药对克罗恩病术后复发的影响.结果 随访18.2(0.88～ 88.0)个月后,AZA组与IFX+AZA组术后复发率分别为52.0％和44.4％,2组间差异无统计学意义(P=0.925).未用药组的复发率为75.0％,均高于AZA组及IFX+AZA组,但差异均无统计学意义(P=0.022和P=0.049).结论 AZA组与IFX+AZA组术后复发率差异无统计学意义,虽然二者均低于未用药组,但差异均无统计学意义.

Objective To evaluate the effects of azathioprine(AZA) or combination of azathioprine and infliximab (AZA + IFX) on postoperative recurrence (POR) of Crohn' s disease (CD),and to analyze the risk factors associated with POR.Methods Ninety-nine patients who received surgical resections at Nanfang Hospital of Southern Medical University were included.Twenty-five patients received AZA,18 patients received AZA + IFX and 56 patients did not receive any prophylactic treatment.The effects of different medication on recurrence of CD were compared.Results After a follow-up period of 18.2(0.88-88.0) months,the incidence of POR in AZA group and AZA + IFX group was 52.0％ and 44.4％ respectively without significant difference (P =0.925).The incidence of recurrence in non-treatment group was 75.0％,which was lower than that in AZA group (P=0.022) and AZA+IFX groups (P=0.049),but the differences were not significant as well.Conclusion The incidence of POR between AZA group and AZA+IFX group is not significantly different,meanwhile although incidences in both groups are lower as compared to non-treatment group,but the differences are not significantly different as well.