急性草甘膦与草铵膦中毒23例临床分析

Acute Glyphosate and Glufosinate intoxication: A Clinical Analysis of 23 Cases

目的:随着草甘膦及草铵膦应用的增多,其中毒患者也逐渐增多,本文探讨其中毒的临床特点,为其诊断治疗提供科学依据。方法:总结分析我院2016年1月—2017年6月收治的23例草甘膦与草铵膦中毒患者的临床表现、实验室检查、诊治经过及预后。结果:急性草甘膦中毒15例,急性草铵膦中毒8例。其中男性13例,女性10例,年龄14~70岁。口服量20~400 ml,临床表现主要为消化道、呼吸道、心血管系统及神经系统等多脏器损伤,2例严重病例出现呼吸衰竭。经综合治疗全部好转出院。结论:草甘膦及草铵膦中毒症状相似,大部分中毒患者症状较轻、预后良好,但重症患者也存在呼吸衰竭等致死情况,需早期诊断及处理。

Objective:To explore the clinical characters of Glyphosate and Glufosinate intoxication,and provide scientific evidence of diagnosis. Methods:The clinical manifestations,laboratory examinations,process of diagnosis and treatment,and prognosis of 23 patients admitted in our hospital from January 2016 to June 2017 were summarized and analyzed. Results:A total of 15 patients suffered from acute Glyphosate intoxication and 8 from acute Glufosinate intoxication. 13 males and 10 females,aged 14-70 years. The oral dosage was 20-400 ml. The clinical manifestations of intoxication were marked by multi-organ injury in digestive tract,respiratory tract,cardiovascular system and nerve system. Two severe patients suffered from respiratory failure. All patients were discharged from hospital after comprehensive treatment. Conclusion:Glyphosate intoxication is similar to Glufosinate intoxication in clinical symptoms,and most patients with intoxication are mild in clinical symptoms and favorable in prognosis,while severe patients need to be diagnosed and treated early as they often have fatal conditions like respiratory failure.