HIV/AIDS抗病毒治疗免疫重建效果分析

目的 分析艾滋病病毒感染者/艾滋病患者(HIV/AIDS)抗病毒治疗前后CD4+T淋巴细胞计数的变化,评估抗病毒治疗免疫重建效果.方法 收集2013年至2016年237例HIV/AIDS抗病毒治疗个案随访记录,对CD4+T淋巴细胞计数变化进行分析.结果 HIV/AIDS经抗病毒治疗3、6、9、12个月后,CD4+T淋巴细胞计数逐步增长,治疗不同疗程CD4+T淋巴细胞计数与基线比较,差异有统计学意义(P<0.01);不同基线治疗12个月后CD4+T淋巴细胞计数增长,差异有统计学意义(χ2=6.086,P<0.05).结论 高效抗反转录病毒治疗免疫重建效果显著,早期治疗效果好,故艾滋病管理应做到早诊断、早治疗.

Objective To analyze the changes of CD4+T lymphocyte cell count of HIV/AIDS patients before and after antiretroviral therapy, and to evaluate the immune reconstruction efficacy of antiretroviral therapy. Methods The China information system for disease control and prevention was used to collect the follow-up records of 237 HIV/AIDS cases from 2013 to 2016 in Cixi city,then the changes of CD4+T lymphocyte cell count were analyzed. Results The CD4+T lymphocyte cell count increased gradually after 3,6,9 and 12 months of antiretroviral therapy. The CD4+T lymphocyte cell count of different time points after antiretroviral therapy showed differences compared with the baseline data(P<0.01). There were statistically significant differences in the results of CD4+T lymphocyte cell count which increased after 12 months of different baseline patients(χ2=6.086, P<0.05). Conclusions The Highly active antiretroviral therapy has a remarkable effectiveness on immune reconstruction in HIV/AIDS patients,and early treatment is more effective. Therefore,AIDS management should be early diagnosis and treatment.