本文针对人工折叠滤袋劳动强度大、生产率低等问题,设计了一种滤袋的自动折叠机。首先对梳齿式滤袋折叠机进行了方案设计和结构设计,对梳齿式滤袋折叠机折叠滤袋的过程进行了几何分析;开展了下压气缸输入压强、滤袋材质、下压气缸杆运...本文针对人工折叠滤袋劳动强度大、生产率低等问题,设计了一种滤袋的自动折叠机。首先对梳齿式滤袋折叠机进行了方案设计和结构设计,对梳齿式滤袋折叠机折叠滤袋的过程进行了几何分析;开展了下压气缸输入压强、滤袋材质、下压气缸杆运行速度对下压气缸对滤袋推力的影响因素的三因素三水平正交试验。极差分析结果表明:下压气缸对滤袋推力的影响最大组合为A1B3C3,下压气缸对滤袋推力值为94.5 N;下压气缸对滤袋推力值最小组合为A3B2C1,下压气缸对滤袋推力值为20.2 N。方差分析结果表明:下压气缸输入压强和滤袋材质对下压气缸对滤袋推力的影响显著,下压气缸杆运行速度对下压气缸对滤袋推力的影响不显著。试验结果为滤袋折叠机的设计和开发提供了理论依据。This paper addresses issues such as the high labor intensity and low productivity associated with manually folding filter bags and proposes the design of an automatic filter bag folding machine. Initially, a conceptual and structural design was carried out for a comb-type filter bag folding machine, and a geometric analysis was performed on the filter bag folding process of the comb-type folding machine. A three-factor, three-level orthogonal experiment was conducted to examine the effects of the input pressure of the pressing cylinder, the filter bag material, and the operating speed of the pressing cylinder rod on the thrust exerted by the pressing cylinder on the filter bag. The range analysis results indicate that the combination producing the maximum thrust on the filter bag by the pressing cylinder is A1B3C3, with a thrust value of 94.5 N. Conversely, the combination yielding the minimum thrust is A3B2C1, with a thrust value of 20.2 N. The variance analysis results show that the input pressure of the pressing cylinder and the filter bag material significantly affect the thrust exerted by the pressing cylinder on the filter bag, while the operating speed of the pressing cylinder rod does not have a significant impact. The experimental results provide a theoretical basis for the design and development of the filter bag folding machine.展开更多
文摘本文针对人工折叠滤袋劳动强度大、生产率低等问题,设计了一种滤袋的自动折叠机。首先对梳齿式滤袋折叠机进行了方案设计和结构设计,对梳齿式滤袋折叠机折叠滤袋的过程进行了几何分析;开展了下压气缸输入压强、滤袋材质、下压气缸杆运行速度对下压气缸对滤袋推力的影响因素的三因素三水平正交试验。极差分析结果表明:下压气缸对滤袋推力的影响最大组合为A1B3C3,下压气缸对滤袋推力值为94.5 N;下压气缸对滤袋推力值最小组合为A3B2C1,下压气缸对滤袋推力值为20.2 N。方差分析结果表明:下压气缸输入压强和滤袋材质对下压气缸对滤袋推力的影响显著,下压气缸杆运行速度对下压气缸对滤袋推力的影响不显著。试验结果为滤袋折叠机的设计和开发提供了理论依据。This paper addresses issues such as the high labor intensity and low productivity associated with manually folding filter bags and proposes the design of an automatic filter bag folding machine. Initially, a conceptual and structural design was carried out for a comb-type filter bag folding machine, and a geometric analysis was performed on the filter bag folding process of the comb-type folding machine. A three-factor, three-level orthogonal experiment was conducted to examine the effects of the input pressure of the pressing cylinder, the filter bag material, and the operating speed of the pressing cylinder rod on the thrust exerted by the pressing cylinder on the filter bag. The range analysis results indicate that the combination producing the maximum thrust on the filter bag by the pressing cylinder is A1B3C3, with a thrust value of 94.5 N. Conversely, the combination yielding the minimum thrust is A3B2C1, with a thrust value of 20.2 N. The variance analysis results show that the input pressure of the pressing cylinder and the filter bag material significantly affect the thrust exerted by the pressing cylinder on the filter bag, while the operating speed of the pressing cylinder rod does not have a significant impact. The experimental results provide a theoretical basis for the design and development of the filter bag folding machine.
文摘目的 探讨芹菜素(AP)通过瞬时受体离子通道4(TRPV4)调控蛋白激酶R样内质网激酶(PERK)-增强子结合蛋白同源蛋白(CHOP)内质网应激途径,改善帕金森病(PD)模型大鼠神经功能的机制研究。方法 选取50只大鼠通过6-羟基多巴胺建立PD模型。将大鼠随机分为PD组、AP低剂量(AP-L,20 mg/kg AP)组、AP中剂量(AP-M,40 mg/kg AP)组、AP高剂量(AP-H,80 mg/kg AP)组、TRPV4激活剂(AP-H+4α-PDD,80 mg/kg AP+0.2 mg/kg 4α-PDD)组,每组10只,同时以生理盐水灌胃的10只正常大鼠为对照组。药物治疗结束后,进行大鼠行为学检测,观察其病理学变化、凋亡细胞、超氧化物歧化酶(SOD)、还原型谷胱甘肽(GSH)、丙二醛(MDA)、酪氨酸羟化酶(TH)表达水平及TRPV4、PERK、CHOP表达情况。结果 与对照组比较,PD组TH阳性表达率、GSH、SOD含量显著降低,旋转圈数、细胞凋亡率、MDA含量、TRPV4、PERK、CHOP表达显著增加(P<0.05);与PD组比较,AP-L组、AP-M组、AP-H组TH阳性表达率、GSH、SOD含量显著增加,治疗后旋转圈数、细胞凋亡率、MDA含量、TRPV4、PERK、CHOP表达显著降低(P<0.05);与AP-H组比较,AP-H+4α-PDD组TH阳性表达率[(15.34±1.54)%vs(30.35±3.04)%]、SOD[(125.84±12.59 vs 185.34±18.55)U/mg]、GSH[(38.46±3.85 vs 75.19±7.52)U/mg]含量显著降低,细胞凋亡率[(26.37±2.64)%vs(11.04±1.11)%]、TRPV4(0.58±0.06 vs 0.23±0.03)、PERK(0.76±0.08 vs 0.38±0.04)、CHOP(0.82±0.09 vs 0.35±0.04)表达显著增加(P<0.05)。结论 AP可以保护PD大鼠神经功能,可能与抑制TRPV4调控PERK-CHOP内质网应激途径有关。
