癫痫抑郁共病是癫痫患者最常见的情绪障碍共病模式,癫痫抑郁两病病理上互相影响,且抗癫痫药物会加重情绪障碍,抗抑郁药物会加重癫痫发作,综合治疗不理想。中医药在该病治疗上的探索取得了一定的成果,具有多环节、多途径、多靶点的优势作...癫痫抑郁共病是癫痫患者最常见的情绪障碍共病模式,癫痫抑郁两病病理上互相影响,且抗癫痫药物会加重情绪障碍,抗抑郁药物会加重癫痫发作,综合治疗不理想。中医药在该病治疗上的探索取得了一定的成果,具有多环节、多途径、多靶点的优势作用,且可以降低西药的不良反应,改善患者的共病症状。本研究从临床研究和实验研究两方面,对中医药治疗癫痫抑郁共病进行综述,以期为临床提供参考。Epilepsy comorbid depression is the most common pattern of mood disorder co-morbidity in patients with epilepsy, and epilepsy-depression two diseases pathologically interact with each other, and antiepileptic drugs aggravate the mood disorder, antidepressant drugs aggravate the epileptic seizures, and the comprehensive treatment is not ideal. The exploration of Chinese medicine in the treatment of this disease has achieved certain results, with the advantageous effects of multi-link, multi-pathway, multi-targets, and can reduce the adverse effects of western drugs and improve the co-morbid symptoms of patients. This study reviews the clinical research and experimental research progress of traditional Chinese medicine in the treatment of epilepsy and depression comorbidities, in order to provide clinical reference.展开更多
文摘癫痫抑郁共病是癫痫患者最常见的情绪障碍共病模式,癫痫抑郁两病病理上互相影响,且抗癫痫药物会加重情绪障碍,抗抑郁药物会加重癫痫发作,综合治疗不理想。中医药在该病治疗上的探索取得了一定的成果,具有多环节、多途径、多靶点的优势作用,且可以降低西药的不良反应,改善患者的共病症状。本研究从临床研究和实验研究两方面,对中医药治疗癫痫抑郁共病进行综述,以期为临床提供参考。Epilepsy comorbid depression is the most common pattern of mood disorder co-morbidity in patients with epilepsy, and epilepsy-depression two diseases pathologically interact with each other, and antiepileptic drugs aggravate the mood disorder, antidepressant drugs aggravate the epileptic seizures, and the comprehensive treatment is not ideal. The exploration of Chinese medicine in the treatment of this disease has achieved certain results, with the advantageous effects of multi-link, multi-pathway, multi-targets, and can reduce the adverse effects of western drugs and improve the co-morbid symptoms of patients. This study reviews the clinical research and experimental research progress of traditional Chinese medicine in the treatment of epilepsy and depression comorbidities, in order to provide clinical reference.