目的探讨血清可溶性白细胞介素-2受体(sIL-2R)、降钙素原、微小RNA(miR)-223与新生儿肺炎病情程度及转归的关系。方法回顾性选取2018年1月至2023年6月池州市第二人民医院新生儿科收治的80例新生儿肺炎患儿作为肺炎组,另外选取本院同期...目的探讨血清可溶性白细胞介素-2受体(sIL-2R)、降钙素原、微小RNA(miR)-223与新生儿肺炎病情程度及转归的关系。方法回顾性选取2018年1月至2023年6月池州市第二人民医院新生儿科收治的80例新生儿肺炎患儿作为肺炎组,另外选取本院同期出生的健康新生儿80名作为对照组。对比两组的血清sIL-2R、降钙素原、miR-223水平。并按照患儿病情程度、治疗转归进行分组,其中,轻度组患儿44例,重度组患儿36例;经过治疗,预后良好组患儿63例,预后不良组患儿17例。对比不同病情程度、不同转归新生儿肺炎患儿血清sIL-2R、降钙素原、miR-223水平。采用多因素Logistic回归模型分析血清sIL-2R、降钙素原、miR-223与患儿治疗转归结局的关系。结果肺炎组患儿血清sIL-2R、降钙素原、miR-223水平分别为(32.40±8.94)μg/mL、(10.40±2.91)ng/mL、9.84±2.77,均显著高于对照组[(15.48±3.84)μg/mL、(5.84±1.50)ng/mL、6.10±1.84],差异均有统计学意义(P<0.05)。重度组患儿的血清sIL-2R、降钙素原、miR-223水平分别为(36.63±8.70)μg/mL、(12.44±2.70)ng/mL、11.65±2.32,均显著高于轻度组[(28.94±6.13)μg/mL、(8.73±2.65)ng/mL、8.36±2.45],差异均有统计学意义(P<0.05)。预后不良组患儿的血清sIL-2R、降钙素原、miR-223水平分别为(40.85±6.92)μg/mL、(15.70±2.56)ng/mL、15.10±2.13,均显著高于预后良好组[(30.12±8.77)μg/mL、(8.97±2.43)ng/mL、8.42±2.65],差异均有统计学意义(P<0.05)。不同分娩孕周(≥37周vs.<37周)、不同出生体重(≥2500 g vs.<2500 g)、不同出生1 min Apgar评分(≥8分vs.<8分)的新生儿肺炎患儿的转归结局比较,差异均有统计学意义(P<0.05);Logistic回归模型分析,结果显示:分娩孕周<37周、出生体重<2500 g、出生1 min Apgar评分<8分及血清sIL-2R升高、降钙素原升高、miR-223升高是新生儿肺炎患儿治疗转归结局不良的独立危险因素(P<0.05)。结论新生儿肺炎患儿血清sIL-2R、降钙素原、miR-223水平显著提高,并且与患儿病情程度、不良预后结局关系密切。展开更多
We conduct a detailed examination of the magnetic and electrical transport properties in GdAlSi and SmAlGe crystals,which possess a LaPtSi-type structure(space group I4_(1)md).The magnetic susceptibility data unambigu...We conduct a detailed examination of the magnetic and electrical transport properties in GdAlSi and SmAlGe crystals,which possess a LaPtSi-type structure(space group I4_(1)md).The magnetic susceptibility data unambiguously reveal magnetic ordering below a characteristic transition temperature(T_(N)).For GdAlSi,a hysteresis loop is observed in the magnetization and magnetoresistance curves within the ab plane when the magnetic field is applied below T_(N),which is around32 K.Notable specific heat anomalies are detected at 32 K for GdAlSi and 6 K for SmAlGe,confirming the occurrence of magnetic transitions.In addition,the extracted magnetic entropy at high temperatures is consistent with the theoretical value of Rln(2J+1) for J=7/2 in Gd^(3+) and J=5/2 in Sm^(3+),respectively.SmAlGe also exhibits Schottky-like specific heat contributions.Additionally,both GdAlSi and SmAlGe exhibit positive magnetoresistance and a normal Hall effect.展开更多
文摘目的探讨血清可溶性白细胞介素-2受体(sIL-2R)、降钙素原、微小RNA(miR)-223与新生儿肺炎病情程度及转归的关系。方法回顾性选取2018年1月至2023年6月池州市第二人民医院新生儿科收治的80例新生儿肺炎患儿作为肺炎组,另外选取本院同期出生的健康新生儿80名作为对照组。对比两组的血清sIL-2R、降钙素原、miR-223水平。并按照患儿病情程度、治疗转归进行分组,其中,轻度组患儿44例,重度组患儿36例;经过治疗,预后良好组患儿63例,预后不良组患儿17例。对比不同病情程度、不同转归新生儿肺炎患儿血清sIL-2R、降钙素原、miR-223水平。采用多因素Logistic回归模型分析血清sIL-2R、降钙素原、miR-223与患儿治疗转归结局的关系。结果肺炎组患儿血清sIL-2R、降钙素原、miR-223水平分别为(32.40±8.94)μg/mL、(10.40±2.91)ng/mL、9.84±2.77,均显著高于对照组[(15.48±3.84)μg/mL、(5.84±1.50)ng/mL、6.10±1.84],差异均有统计学意义(P<0.05)。重度组患儿的血清sIL-2R、降钙素原、miR-223水平分别为(36.63±8.70)μg/mL、(12.44±2.70)ng/mL、11.65±2.32,均显著高于轻度组[(28.94±6.13)μg/mL、(8.73±2.65)ng/mL、8.36±2.45],差异均有统计学意义(P<0.05)。预后不良组患儿的血清sIL-2R、降钙素原、miR-223水平分别为(40.85±6.92)μg/mL、(15.70±2.56)ng/mL、15.10±2.13,均显著高于预后良好组[(30.12±8.77)μg/mL、(8.97±2.43)ng/mL、8.42±2.65],差异均有统计学意义(P<0.05)。不同分娩孕周(≥37周vs.<37周)、不同出生体重(≥2500 g vs.<2500 g)、不同出生1 min Apgar评分(≥8分vs.<8分)的新生儿肺炎患儿的转归结局比较,差异均有统计学意义(P<0.05);Logistic回归模型分析,结果显示:分娩孕周<37周、出生体重<2500 g、出生1 min Apgar评分<8分及血清sIL-2R升高、降钙素原升高、miR-223升高是新生儿肺炎患儿治疗转归结局不良的独立危险因素(P<0.05)。结论新生儿肺炎患儿血清sIL-2R、降钙素原、miR-223水平显著提高,并且与患儿病情程度、不良预后结局关系密切。
基金supported by the National Natural Science Foundation of China(Grant No.12074425)the National Key R&D Program of China(Grant No.2019YFA0308602)+1 种基金the Fundamental Research Funds for the Central Universitiesthe Research Funds of Renmin University of China(Grant No.23XNKJ22)。
文摘We conduct a detailed examination of the magnetic and electrical transport properties in GdAlSi and SmAlGe crystals,which possess a LaPtSi-type structure(space group I4_(1)md).The magnetic susceptibility data unambiguously reveal magnetic ordering below a characteristic transition temperature(T_(N)).For GdAlSi,a hysteresis loop is observed in the magnetization and magnetoresistance curves within the ab plane when the magnetic field is applied below T_(N),which is around32 K.Notable specific heat anomalies are detected at 32 K for GdAlSi and 6 K for SmAlGe,confirming the occurrence of magnetic transitions.In addition,the extracted magnetic entropy at high temperatures is consistent with the theoretical value of Rln(2J+1) for J=7/2 in Gd^(3+) and J=5/2 in Sm^(3+),respectively.SmAlGe also exhibits Schottky-like specific heat contributions.Additionally,both GdAlSi and SmAlGe exhibit positive magnetoresistance and a normal Hall effect.