目的研究阿伐曲泊帕对等待肝移植患者伴重度血小板减少症(thrombocytopenia,TCP)的治疗作用。方法通过回顾郑州大学第一附属医院2021年2月至2022年10月间67例等待肝移植并伴重度TCP患者的临床资料,收集患者一般情况资料及阿伐曲泊帕使...目的研究阿伐曲泊帕对等待肝移植患者伴重度血小板减少症(thrombocytopenia,TCP)的治疗作用。方法通过回顾郑州大学第一附属医院2021年2月至2022年10月间67例等待肝移植并伴重度TCP患者的临床资料,收集患者一般情况资料及阿伐曲泊帕使用前后患者血小板计数情况。治疗后血小板计数升至≥50×10^(9)/L为治疗有效。根据是否联合应用重组人血小板生成素(recombinant human thrombopoietin,rhTPO)将患者分为两组(单药治疗组和联合治疗组)进行分析。结果在伴有重度TCP的67例等待肝移植患者中,应用阿伐曲泊帕治疗后患者血小板计数与治疗前相比显著升高(P=0.001),其中89.55%(60/67)的患者治疗后血小板计数升至≥50×10^(9)/L,有效率在不同程度的血小板减少组间无统计学差异(P=0.373)。亚组分析表明,联合治疗组治疗后血小板计数显著高于单药治疗组(P=0.002),而用药前血小板计数无统计学差异(P=0.064)。在单药治疗组中85.00%(34/40)患者血小板计数升至≥50×10^(9)/L,联合治疗组(27例)中96.30%(26/27)患者治疗后血小板计数升至≥50×10^(9)/L,两组间比较不具有统计学差异(P=0.228)。结论阿伐曲泊帕可提高伴有重度TCP等待肝移植患者的血小板水平,与rhTPO联用可能存在叠加作用。展开更多
Optical filters capable of single control parameter based wide tuning are implemented and studied.A prototype surface micromachined 1 3μm Si based MOEMS (micro opto electro mechanical systems) tunable filter e...Optical filters capable of single control parameter based wide tuning are implemented and studied.A prototype surface micromachined 1 3μm Si based MOEMS (micro opto electro mechanical systems) tunable filter exhibits a continuous and large tuning range of 90nm at 50V tuning voltage.The filter can be integrated with Si based photodetector in a low cost component for coarse wavelength division multiplexing systems operating in the 1 3μm band.展开更多
A 1.55μm Fabry-Perot (F-P) thermo-optical t unable filter is fabricated.The cavity is made of amorphous silicon (a-Si) layer grown by electron-beam evaporation technique.Due to the excellent thermo-optical property o...A 1.55μm Fabry-Perot (F-P) thermo-optical t unable filter is fabricated.The cavity is made of amorphous silicon (a-Si) layer grown by electron-beam evaporation technique.Due to the excellent thermo-optical property of a-Si,the refractive index of the F-P cavity will be changed by heating;the transmittance resonant peak will therefore shift substantially.The measured tuning rang is 12nm, FWHM (full-width-at-half-maximum) of the transmissi on peak is 9nm,and heating efficiency is 0.1K/mW.The large FWHM is mainly due to th e non-ideal coating deposition and mirror undulation.Possible improvements to increase the efficiency of heating are suggested.展开更多
文摘目的研究阿伐曲泊帕对等待肝移植患者伴重度血小板减少症(thrombocytopenia,TCP)的治疗作用。方法通过回顾郑州大学第一附属医院2021年2月至2022年10月间67例等待肝移植并伴重度TCP患者的临床资料,收集患者一般情况资料及阿伐曲泊帕使用前后患者血小板计数情况。治疗后血小板计数升至≥50×10^(9)/L为治疗有效。根据是否联合应用重组人血小板生成素(recombinant human thrombopoietin,rhTPO)将患者分为两组(单药治疗组和联合治疗组)进行分析。结果在伴有重度TCP的67例等待肝移植患者中,应用阿伐曲泊帕治疗后患者血小板计数与治疗前相比显著升高(P=0.001),其中89.55%(60/67)的患者治疗后血小板计数升至≥50×10^(9)/L,有效率在不同程度的血小板减少组间无统计学差异(P=0.373)。亚组分析表明,联合治疗组治疗后血小板计数显著高于单药治疗组(P=0.002),而用药前血小板计数无统计学差异(P=0.064)。在单药治疗组中85.00%(34/40)患者血小板计数升至≥50×10^(9)/L,联合治疗组(27例)中96.30%(26/27)患者治疗后血小板计数升至≥50×10^(9)/L,两组间比较不具有统计学差异(P=0.228)。结论阿伐曲泊帕可提高伴有重度TCP等待肝移植患者的血小板水平,与rhTPO联用可能存在叠加作用。
文摘Optical filters capable of single control parameter based wide tuning are implemented and studied.A prototype surface micromachined 1 3μm Si based MOEMS (micro opto electro mechanical systems) tunable filter exhibits a continuous and large tuning range of 90nm at 50V tuning voltage.The filter can be integrated with Si based photodetector in a low cost component for coarse wavelength division multiplexing systems operating in the 1 3μm band.
文摘A 1.55μm Fabry-Perot (F-P) thermo-optical t unable filter is fabricated.The cavity is made of amorphous silicon (a-Si) layer grown by electron-beam evaporation technique.Due to the excellent thermo-optical property of a-Si,the refractive index of the F-P cavity will be changed by heating;the transmittance resonant peak will therefore shift substantially.The measured tuning rang is 12nm, FWHM (full-width-at-half-maximum) of the transmissi on peak is 9nm,and heating efficiency is 0.1K/mW.The large FWHM is mainly due to th e non-ideal coating deposition and mirror undulation.Possible improvements to increase the efficiency of heating are suggested.
