恶性肿瘤在临床上是一种常见的疑难疾病。峨参,一种源自四川省峨眉山的道地中药材,现代科学研究揭示了其较好的抗肿瘤特性,对多种肿瘤细胞具有明显的抑制效果。本文通过深入解析中药峨参对肿瘤的治疗机制,指导临床辨证论治过程中的峨参...恶性肿瘤在临床上是一种常见的疑难疾病。峨参,一种源自四川省峨眉山的道地中药材,现代科学研究揭示了其较好的抗肿瘤特性,对多种肿瘤细胞具有明显的抑制效果。本文通过深入解析中药峨参对肿瘤的治疗机制,指导临床辨证论治过程中的峨参应用。Malignant tumor is a common and difficult disease in clinic. Anthriscus sylvestris (L.) Hoffm. Gen., a kind of authentic Chinese medicine originating from Mount Emei in Sichuan province, has been revealed by modern scientific research to have good anti-tumor properties and has obvious inhibitory effect on a variety of tumor cells. In this investigation, the mechanism of Chinese medicine Anthriscus sylvestris (L.) Hoffm. Gen. on tumor treatment was analyzed to guide the application of Anthriscus sylvestris (L.) Hoffm. Gen. in clinical differentiation and treatment.展开更多
Objective The objective of this study was to investigate potential mechanisms of Yanghe Decoction(YHD)in treating soft tissue sarcoma(STS)and arteriosclerosis obliterans(ASO)based on the use of network pharmacology.Me...Objective The objective of this study was to investigate potential mechanisms of Yanghe Decoction(YHD)in treating soft tissue sarcoma(STS)and arteriosclerosis obliterans(ASO)based on the use of network pharmacology.Methods Candidate compounds and potential targets were identifed through the TCM Systems Pharmacology database and a comprehensive literature search.Related targets of STS and ASO were collected in the GeneCards database,DisGeNET database,and Drugbank database.Furthermore,The STRING 11.0 database was used to determine protein-protein interaction(PPI)networks;common targets were obtained and imported into Cytoscape 3.7.2.Then,a PPI network comprising common targets was drawn,and network topology analysis was performed to screen for key shared targets.Gene ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of key shared targets were performed by using Metascape software.Subsequently.a compound-target-pathway network was constructed via Cytoscape 3.7.2.Results The following signaling pathways were found to be associated with the mechanisms of YHD in treating STS and ASO:AGE-RAGE signaling pathway,IL-17 signaling pathway;HIF-1 signaling pathway,TNF signaling pathway,interactions between cytokines and cytokine receptors,Th17 cell differentiation,and NOD-like receptor signaling pathway.Among the compounds and targets involved in these pathways,quercetin,luteolin,and kaempferol were found to be core compounds,and TNF,IL-6,and MAPK1 were found to be core targets.Conclusion Taken together,our findings elucidated that potential mechanisms of YHD in treating STS and ASO involved cellular proliferation/differentiation,angiogen-esis,inflammation,immune responses,oxidative stress,and other related signaling pathways.展开更多
文摘恶性肿瘤在临床上是一种常见的疑难疾病。峨参,一种源自四川省峨眉山的道地中药材,现代科学研究揭示了其较好的抗肿瘤特性,对多种肿瘤细胞具有明显的抑制效果。本文通过深入解析中药峨参对肿瘤的治疗机制,指导临床辨证论治过程中的峨参应用。Malignant tumor is a common and difficult disease in clinic. Anthriscus sylvestris (L.) Hoffm. Gen., a kind of authentic Chinese medicine originating from Mount Emei in Sichuan province, has been revealed by modern scientific research to have good anti-tumor properties and has obvious inhibitory effect on a variety of tumor cells. In this investigation, the mechanism of Chinese medicine Anthriscus sylvestris (L.) Hoffm. Gen. on tumor treatment was analyzed to guide the application of Anthriscus sylvestris (L.) Hoffm. Gen. in clinical differentiation and treatment.
基金supported by 2018 scientific and technological research projectsin Henan Province(192102310430)Special Project of Chinese Medicine Research in Henan Province(2019ZYZD06)。
文摘Objective The objective of this study was to investigate potential mechanisms of Yanghe Decoction(YHD)in treating soft tissue sarcoma(STS)and arteriosclerosis obliterans(ASO)based on the use of network pharmacology.Methods Candidate compounds and potential targets were identifed through the TCM Systems Pharmacology database and a comprehensive literature search.Related targets of STS and ASO were collected in the GeneCards database,DisGeNET database,and Drugbank database.Furthermore,The STRING 11.0 database was used to determine protein-protein interaction(PPI)networks;common targets were obtained and imported into Cytoscape 3.7.2.Then,a PPI network comprising common targets was drawn,and network topology analysis was performed to screen for key shared targets.Gene ontology functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis of key shared targets were performed by using Metascape software.Subsequently.a compound-target-pathway network was constructed via Cytoscape 3.7.2.Results The following signaling pathways were found to be associated with the mechanisms of YHD in treating STS and ASO:AGE-RAGE signaling pathway,IL-17 signaling pathway;HIF-1 signaling pathway,TNF signaling pathway,interactions between cytokines and cytokine receptors,Th17 cell differentiation,and NOD-like receptor signaling pathway.Among the compounds and targets involved in these pathways,quercetin,luteolin,and kaempferol were found to be core compounds,and TNF,IL-6,and MAPK1 were found to be core targets.Conclusion Taken together,our findings elucidated that potential mechanisms of YHD in treating STS and ASO involved cellular proliferation/differentiation,angiogen-esis,inflammation,immune responses,oxidative stress,and other related signaling pathways.
