Association of Various Anthropometric Indices with Sudomotor Dysfunction in Type 2 Diabetic Patients

Aim: To investigate the relationship between sudomotor dysfunction and various body composition analysis indices in type 2 diabetic patients. Methods: Between January 2016 and April 2021, 136 diabetic participants who had undergone body composition analysis (BCA) were recruited for this cross-sectional study. Sudomotor functions were assessed using SUDOSCAN, and participants were grouped into patients with normal (Group 1, n = 51), mildly reduced (Group 2, n = 46) and severely reduced (Group 3, n = 39) foot electrochemical skin conductance (FESC) levels. Results: The mean age was 60.4 ± 10.1 years, median diabetes duration was 12 (6 - 19) years, and 52.2% of participants were males. Among BCA parameters, the significant differences were found in total fat (TF) (p = 0.023), percentage of TF (%TF) (p = 0.025), percentage of android fat (%AF) (p = 0.048), fat mass (FM) in arms (p = 0.016), FM in legs (p = 0.002), appendicular fat mass (aFM) (p = 0.002), appendicular fat mass/body mass index (aFM/BMI) ratio (p = 0.009) between three groups. In Spearman correlation analysis, FESC was correlated with RBC, ESR and homocysteine (r = 0.171, r = −0.190, r = −0.192, p β =0.161, 0.155, 0.165, 0.185, p Conclusion: The progressive decline of sudomotor function is positively associated with loss of subcutaneous fat in arms and legs, suggesting that subcutaneous fat of extremities may be necessary to prevent DPN progression in type 2 diabetic patients.

The Spectrum of Kidney Disease in Type Two Diabetic Patients: A Single-Center Study

Background: Diabetic nephropathy (DN) is the dominant reason for end-stage kidney disease linked with a rise in cardiovascular mortality rate. However, besides DN, type 2 diabetic patients may also suffer from various non-diabetic renal diseases (NDRD). Aim: The objective of the current research was to assess the occurrence and type of NDRD diagnosed by kidney biopsy in type 2 diabetic subjects, evaluate the association of various clinical and laboratory characteristics with histopathology findings, and identify essential predictors of NDRD. Methods: Retrospective analysis has been performed through medical record revision of 101 patients with type 2 diabetes undergoing percutaneous renal biopsy at Qilu Hospital of Shandong University (Jinan, China) between January 2015 and December 2020. Results: Renal biopsy results showed that NDRD was found in 59 patients (58.42%), while DN existed in 32 patients (31.68%) and 10 patients (9.90%) showed DN complicated with NDRD. Membranous nephropathy was prevailing NDRD (42%), followed by focal segmental glomerulosclerosis (11.6%) and IgA nephropathy (10.1%). In univariate analysis, patients with NDRD had older age (p Conclusions: Clinical parameters such as short duration of diabetes, older age, higher hemoglobin level, and lower proteinuria might be associated with NDRD in type 2 diabetic patients. An early diagnosis of NDRD poses a favorable renal prognosis because it requires a different approach than DN, further larger multicenter randomized prospective investigations focused on identifying possible risk markers of NDRD are still in priority.

The Impact of Fresh Gas Flow Sevoflurane Anesthesia on Perioperative Hypothermia in Adult Patients Undergoing Elective Open or Laparoscopic Digestive Surgery: A Prospective Randomized Controlled Trial

Background: Because body temperature is such an important indicator and a basic requirement for all kinds of life, even tiny variances might induce undesired changes. This study looked at the influence of FGFs sevoflurane anesthesia on heat preservation in patients undergoing open or laparoscopic digestive surgery. Materials and Methods: Two hundred and forty adult patients (18 - 75 years) with an ASA of I-II were scheduled for open and laparoscopic digestive surgery: open surgery (Group O, n = 120 patients) and laparoscopic surgery (Group L, n = 120 patients). Each group was separated randomly into four subgroups (n = 30 patients) based on FGFs (0.7, 1, 1.5, or 2 L/min). Each patient’s HR, MBP, SpO2, FiO2, fluid infusion amount, urine volume, pre/post-Hb, surgery time, and nasopharyngeal temperatures were investigated and recorded every 15 min from 0 to 120 min. Results: Between groupings, there were no significant changes in demographic features. In 240 patients, the results of various FGFs (0.7, 1, 1.5, and 2 L/min), no statistically significant differences were found in core body temperature over time within each subgroup, with no statistically significant differences between the two (open and laparoscopic) (P > 0.05). Conclusions: The study concluded that FGFs (0.7, 1, 1.5, and 2 L/min) could be utilized safely in adult patients undergoing open or laparoscopic digestive surgery. FGFs (0.7, 1, 1.5, and 2 L/min) provide better body heat preservation during surgical operations.