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羊膜移植联合丝裂霉素C进行穹隆部重建治疗重症瘢痕性眼表疾病 被引量:1
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作者 Tseng S.C.G. di pascuale m.a. +1 位作者 Liu D.T.-S. 王永强 《世界核心医学期刊文摘(眼科学分册)》 2005年第10期57-57,共1页
Purpose: To investigate whether intraoperative application of mitomycin C may enhance the success of amniotic membrane transplantation in symblepharon lysis a nd fornix reconstruction in severe cicatricial ocular surf... Purpose: To investigate whether intraoperative application of mitomycin C may enhance the success of amniotic membrane transplantation in symblepharon lysis a nd fornix reconstruction in severe cicatricial ocular surface diseases. Design: Noncomparative interventional case series. Participants: Sixteen patients (8 fem ale, 8male; 18 eyes)with amean age of 41±23.4 years (range, 3-79) and sufferin g from severe chemical/thermal burns (7 eyes), multiple recurrent pterygia and p seudopterygia (5 eyes), Stevens-Johnson syndrome (4 eyes), and ocular cicatrici al pemphigoid (2 eyes) were consecutively enrolled. All except for 2 eyes had ha d prior surgical attempts of surgical reconstruction, including 6 eyes with a mu cous membrane graft (MMG), but still presented with symblepharon and persistent ocular surface inflammation. Intervention: After excision of subconjunctival fib rovascular tissues, 0.04%mitomycin C was applied for 5 minutes in the deep forn ix before amniotic membrane transplantation. Main Outcome Measures: Deeper forni x, noninflamed ocular surface, and full motility. Results: The mean epithelial h ealing time was 4.2±1.9 weeks. During the follow-up of 14.16±5.2 months, all eyes showed a marked reduction of conjunctival inflammation, a deep fornix, and a continuous tear meniscus. Of 12 eyes with motility restriction, 2 eyes with mu ltiple recurrent pterygia and 1 eye with severe thermal burn showed recurrence o f partial motility restriction 2 months after surgery. The vision of 9 eyes was successfully restored by an additional keratolimbal allograft with subsequent pe netrating keratoplasty (6 eyes). Conclusion: Intraoperative application of mitom ycin C is an effective means to reduce chronic and deep-seated conjunctival inf lammation, and helps amniotic membrane restore a deep fornix after symblepharon lysis, even in eyes that had a failed MMG. Restoration of deep fornix and tear m eniscus is an important prerequisite to achieve successful reconstruction by sub sequent limbal stem cell transplantation. 展开更多
关键词 羊膜移植 瘢痕性 穹隆部 眼表疾病 复发性翼状胬肉 睑球粘连 同种异体角膜缘 热烧伤 眼球运动受限 黏膜移植术
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Stevens-Johnson综合征与中毒性表皮坏死溶解综合征患者角膜并发症与眼睑瘢痕性病理变化间的关系 被引量:1
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作者 di pascuale m.a. Espana E.M. +2 位作者 Liu D.T.-S. S.C.G. Tseng 王永强 《世界核心医学期刊文摘(眼科学分册)》 2005年第10期57-58,共2页
Purpose: To look at the correlation between many factors (time of hospitalizat ion, floppy eyelid syndrome, trichiasis, open lacrimal puncta, symblepharon, and aqueous tear deficiency)-and corneal complications in Ste... Purpose: To look at the correlation between many factors (time of hospitalizat ion, floppy eyelid syndrome, trichiasis, open lacrimal puncta, symblepharon, and aqueous tear deficiency)-and corneal complications in Stevens-Johnson syndrom e (SJS). Design: Observational cases series. Patients: Clinical data were retros pectively reviewed from 38 patients (32.7±20.1 years old) with SJS (n=11) and with toxic epidermal necro lysis (TENS) (n=27) from January 2002 to August 2004. One case report with SJS w as included to verify the presence of tarsal/lid margin ulceration at the acute stage. Methods: The medical history was retrieved regarding presumed causative m edications used within 15 days and the duration of hospitalization. Data of the latest photographic documentation and eye examination were compared and correlat ed in a masked fashion. Main Outcome Measures: Floppy eyelid, trichiasis, lid ma rgin keratinization, meibomian gland orifice metaplasia, symblepharon, tarsal sc ar, and corneal complications. Results: Acute SJS/TENS was characterized by tars al conjunctival ulceration. Keratinization of the eyelid margin with variable de grees of meibomian gland dysfunction was observed in all cases. Floppy eyelid, t richiasis, partially or totally opened lacrimal punctum, symblepharon, and aqueo us tear deficiency were not significantly correlated with corneal complications. In contrast, there was a strong correlation between the severity of eyelid marg in and tarsal pathology and the extent of corneal complications (Spearman r, 0.5 4; P=0.0005). A multivariable regression analysis also showed that the extent of eyelid and tarsal pathology had a significant effect on corneal complications ( coefficient, 0.84; P=0.006). Conclusions: Patients with acute SJS/TENS are chara cterized by severe inflammation and ulceration of the tarsal conjunctiva and lid margins. If left unattended, lid margin keratinization and tarsal scar, togethe r with lipid tear deficiency, contribute to corneal complications because of bli nk-related microtrauma. Attempts to suppress inflammation and scarring by amnio tic membrane transplantation at the acute stage and to prevent microtrauma at th e chronic stage are vital to avoid sight-threatening complications. 展开更多
关键词 瘢痕性 STEVENS 睑板 睑球粘连 睑缘 睑结膜 泪点 致病药物 羊膜移植 泪小点
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