Negatively thermo-responsive 2D membranes,which mimic the stomatal opening/closing of plants,have drawn substantial interest for tunable molecular separation processes.However,these membranes are still restricted sign...Negatively thermo-responsive 2D membranes,which mimic the stomatal opening/closing of plants,have drawn substantial interest for tunable molecular separation processes.However,these membranes are still restricted significantly on account of low water permeability and poor dynamic tunability of 2D nanochannels under temperature stimulation.Here,we present a biomimetic negatively thermo-responsive MXene membrane by covalently grafting poly(N-isopropylacrylamide)(PNIPAm)onto MXene nanosheets.The uniformly grafted PNIPAm polymer chains can enlarge the interlayer spacings for increasing water permeability while also allowing more tunability of 2D nanochannels for enhancing the capability of gradually separating multiple molecules of different sizes.As expected,the constructed membrane exhibits ultrahigh water permeance of 95.6 L m^(-2) h^(-1) bar^(-1) at 25℃,which is eight-fold higher than the state-of-the-art negatively thermoresponsive 2D membranes.Moreover,the highly temperature-tunable 2D nanochannels enable the constructed membrane to perform excellent graded molecular sieving for dye-and antibiotic-based ternary mixtures.This strategy provides new perspectives in engineering smart 2D membrane and expands the scope of temperature-responsive membranes,showing promising applications in micro/nanofluidics and molecular separation.展开更多
A novel biocompatible polymer was prepared by grafting the derivate of β-cyclodextrin （6-SH-β-CD） onto poly（3,4-dihydroxycinnamic acid） （PDHCA） via Michael addition. PDHCA-β-CD nanoparticles were prepared by ...A novel biocompatible polymer was prepared by grafting the derivate of β-cyclodextrin （6-SH-β-CD） onto poly（3,4-dihydroxycinnamic acid） （PDHCA） via Michael addition. PDHCA-β-CD nanoparticles were prepared by the self-assembly of amphiphilic PDHCA-β-CD polymer with N,N-dimethylformamide （DMF） as good solvent and water as poor solvent. The PDHCA-β-CD nanoparticles were monodispersed with spherical morphology as shown in the scanning electron microscopic （SEM） images in accord with the result of dynamic light scattering （DLS） measurement. The size of the nanoparticles could be controlled from 60 to 180 nm by tuning the grafting degree （GD） of PDHCA-β-CD polymer and also significantly influenced by the amount of water used during the process. These as-prepared nanoparticles were stable without any significant change in the particle size after six-months＇ storage and even after being irradiated by UV at 2〉280 nm for hours. The formation mechanism of PDHCA-β-CD nanoparticles was explored. The content of doxombicin （DOX） loaded onto the nanoparticles was up to 39% with relatively high loading efficiency （approximately 78.8% of initial DOX introduced was loaded）. In vitro release studies suggested that DOX released slowly from PDHCA-β-CD nanoparticles. These features strongly support the potential of developing PDHCA-β-CD nanoparticles as carriers for the controlled delivery of drug.展开更多
基金supported by the National Nature Science Foundation of China(No.22278179,U23A20688)the National Key Research and Development Program of China(2021YFB3802600)+3 种基金the Fundamental Research Funds for the Central Universities(JUSRP622035)National First-Class Discipline Program of Light Industry Technology and Engineering(LIFE2018-19)MOE&SAFEA for the 111 Project(B13025)Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01D030).
文摘Negatively thermo-responsive 2D membranes,which mimic the stomatal opening/closing of plants,have drawn substantial interest for tunable molecular separation processes.However,these membranes are still restricted significantly on account of low water permeability and poor dynamic tunability of 2D nanochannels under temperature stimulation.Here,we present a biomimetic negatively thermo-responsive MXene membrane by covalently grafting poly(N-isopropylacrylamide)(PNIPAm)onto MXene nanosheets.The uniformly grafted PNIPAm polymer chains can enlarge the interlayer spacings for increasing water permeability while also allowing more tunability of 2D nanochannels for enhancing the capability of gradually separating multiple molecules of different sizes.As expected,the constructed membrane exhibits ultrahigh water permeance of 95.6 L m^(-2) h^(-1) bar^(-1) at 25℃,which is eight-fold higher than the state-of-the-art negatively thermoresponsive 2D membranes.Moreover,the highly temperature-tunable 2D nanochannels enable the constructed membrane to perform excellent graded molecular sieving for dye-and antibiotic-based ternary mixtures.This strategy provides new perspectives in engineering smart 2D membrane and expands the scope of temperature-responsive membranes,showing promising applications in micro/nanofluidics and molecular separation.
基金This research was supported by the National Nattlral Science Foundation of China （No. 51173072）, the Fun- damental Research Funds for the Central Universities （JUSRP51408B） and Jiangsu Province Joint Innovation Funds （BY2014023-12）.
文摘A novel biocompatible polymer was prepared by grafting the derivate of β-cyclodextrin （6-SH-β-CD） onto poly（3,4-dihydroxycinnamic acid） （PDHCA） via Michael addition. PDHCA-β-CD nanoparticles were prepared by the self-assembly of amphiphilic PDHCA-β-CD polymer with N,N-dimethylformamide （DMF） as good solvent and water as poor solvent. The PDHCA-β-CD nanoparticles were monodispersed with spherical morphology as shown in the scanning electron microscopic （SEM） images in accord with the result of dynamic light scattering （DLS） measurement. The size of the nanoparticles could be controlled from 60 to 180 nm by tuning the grafting degree （GD） of PDHCA-β-CD polymer and also significantly influenced by the amount of water used during the process. These as-prepared nanoparticles were stable without any significant change in the particle size after six-months＇ storage and even after being irradiated by UV at 2〉280 nm for hours. The formation mechanism of PDHCA-β-CD nanoparticles was explored. The content of doxombicin （DOX） loaded onto the nanoparticles was up to 39% with relatively high loading efficiency （approximately 78.8% of initial DOX introduced was loaded）. In vitro release studies suggested that DOX released slowly from PDHCA-β-CD nanoparticles. These features strongly support the potential of developing PDHCA-β-CD nanoparticles as carriers for the controlled delivery of drug.
