氢化物发生-非色散原子荧光光谱法测定粉饼化妆品中Pb,As和Hg含量

建立并优化了氢化物发生-非色散原子荧光光谱法(HG-NDAFS)测定10种粉饼化妆品中铅(Pb),砷(As)和汞(Hg)的含量。确定了较佳载气流速为400 mL/min,屏蔽气流速为800 mL/min。优化了负高压和灯电流,确定了原子化器高度为8 mm。优化还原剂体系时,选择了质量分数1.5%KBH4溶液。载流选择2.4 mol/L HCl。结果显示,Pb,As,Hg的加标回收率分别为83.44%~90.32%,83.22%~86.59%,81.43%~89.94%,加标回收率良好。10种粉饼中共检出2种粉饼中含有Pb(含量0.48和0.27 mg/kg),1种粉饼中含有As(含量0.62 mg/kg),1种粉饼中含有Hg(含量0.11 mg/kg)。10种粉饼中的Pb,As,Hg含量均未超标。本研究建立的HG-NDAFS测定粉饼化妆品中Pb,As和Hg含量的方法准确度高,可用于粉饼化妆品中Pb,As和Hg含量的检测。

Effects of Allelochemicals on Root Growth and Pod Yield in Response to Continuous Cropping Obstacle of Peanut

Continuous cropping(CC)obstacle is a major threat in legume crops production;however,the underlying mechanisms concerning the roles allelochemicals play in CC obstacle are poorly understood.The current 2-year study was conducted to investigate the effects of different kinds and concentrations of allelochemicals,p-hydroxybenzoic acid(H),cinnamic acid(C),phthalic acid(P),and their mixtures(M)on peanut root growth and productivity in response to CC obstacle.Treatment with H,C,P,and M significantly decreased the plant height,dry weight of the leaves and stems,number of branches,and length of the lateral stem compared with control.Exogenous application of H,C,P,and M inhibited the peanut root growth as indicated by the decreased root morphological characters.The allelochemicals also induced the cell membrane oxidation even though the antioxidant enzymes activities were significantly increased in peanut roots.Meanwhile,treatment with H,C,P,and M reduced the contents of total soluble sugar and total soluble protein.Analysis of ATPase activity,nitrate reductase activity,and root system activity revealed that the inhibition effects of allelochemicals on peanut roots might be due to the decrease in activities of ATPase and NR,and the inhibition of root system.Consequently,allelochemicals significantly decreased the pod yield of peanut compared with control.Our results demonstrate that allelochemicals play a dominant role in CC obstacle-induced peanut growth inhibition and yield reduction through damaging the root antioxidant system,unbalancing the osmolytes accumulation,and decreasing the activities of root-related enzymes.

Hyphae-mediated bioassembly of carbon fibers derivatives for advanced battery energy storage

Ingenious design and fabrication of advanced carbon-based sulfur cathodes are extremely important to the development of high-energy lithium-sulfur batteries,which hold promise as the next-generation power source.Herein,for the first time,we report a novel versatile hyphae-mediated biological assembly technology to achieve scale production of hyphae carbon fibers(HCFs)derivatives,in which different components including carbon,metal compounds,and semiconductors can be homogeneously assembled with HCFs to form composite networks.The mechanism of biological adsorption assembly is also proposed.As a representative,reduced graphene oxides(rGOs)decorated with hollow carbon spheres(HCSs)successfully co-assemble with HCFs to form HCSs@rGOs/HCFs hosts for sulfur cathodes.In this unique architecture,not only large accommodation space for sulfur but also restrained volume expansion and fast charge transport paths are realized.Meanwhile,multiscale physical barriers plus chemisorption sites are simultaneously established to anchor soluble lithium polysulfides.Accordingly,the designed HCSs@rGOs/HCFs-S cathodes deliver a high capacity(1189 mA h g^(-1)at 0.1 C)and good high-rate capability(686 mA h g^(-1)at 5 C).Our work provides a new approach for the preparation of high-performance carbon-based electrodes for energy storage devices.

Anisotropic shearing mechanism of Kangding slate:Experimental investigation and numerical analysis

The shear mechanical behavior is regarded as an essential factor affecting the stability of the surrounding rocks in underground engineering.The shear strength and failure mechanisms of layered rock are significantly affected by the foliation angles.Direct shear tests were conducted on cubic slate samples with foliation angles of 0°,30°,45°,60°,and 90°.The effect of foliation angles on failure patterns,acoustic emission(AE)characteristics,and shear strength parameters was analyzed.Based on AE characteristics,the slate failure process could be divided into four stages:quiet period,step-like increasing period,dramatic increasing period,and remission period.A new empirical expression of cohesion for layered rock was proposed,which was compared with linear and sinusoidal cohesion expressions based on the results made by this paper and previous experiments.The comparative analysis demonstrated that the new expression has better prediction ability than other expressions.The proposed empirical equation was used for direct shear simulations with the combined finite-discrete element method(FDEM),and it was found to align well with the experimental results.Considering both computational efficiency and accuracy,it was recommended to use a shear rate of 0.01 m/s for FDEM to carry out direct shear simulations.To balance the relationship between the number of elements and the simulation results in the direct shear simulations,the recommended element size is 1 mm.

Effect of drying cracks on swelling and self-healing of bentonite-sand blocks used as engineered barriers for radioactive waste disposal

Experiments were conducted to evaluate the healing of drying cracks in air-dried bentonite-sand blocks after hydration and swelling in groundwater,providing justifications to simplify the protection of blocks prior to installation in a high-level radioactive waste repository.Synthetic groundwater was prepared to represent the geochemistry of Beishan groundwater,and was used to hydrate the blocks during the swelling pressure and swelling strain measurements,as Beishan is the most promising site for China's repository.Healing of the surface cracks was recorded by photography,and healing of the internal cracks was visualized by CT images and hydraulic conductivity of air-dried blocks.The results indicate that the maximum swelling pressure and swelling strain are primarily affected by the geochemistry of Beishan groundwater,but not affected by the drying cracks.The maximum swelling pressure and swelling strain of air-dried blocks are comparable to or even higher than the pressure and strain of fresh blocks.The maximum swelling pressure measured in strong(i.e.high ion strength)Beishan groundwater was 44%of the pressure measured in deionized(DI)water,and the maximum swelling strain was reduced to 23%of the strain measured in DI water.Nevertheless,the remained swelling of the blocks hydrated in strong Beishan groundwater was sufficient to heal the surface and internal drying cracks,as demonstrated by the pictures of surface cracks and CT images.The hydraulic conductivity of the air-dried block permeated with strong groundwater was comparable(3.7×higher)to the hydraulic conductivity of the fresh block,indicating the self-healing of drying cracks after hydration and swelling in groundwater.A simplified method of protecting the block with plastic wraps before installation is recommended,since the remained swelling of the block hydrated in Beishan groundwater is sufficient to heal the drying cracks.

Highly defective HKUST-1 with excellent stability and SO_(2) uptake: The hydrophobic armor effect of functionalized ionic liquids

Water stability is one of the most important factors restricting the practical application of metal organic frameworks (MOFs). In this work, wefabricate a highly defective HKUST-1 framework with a mixed valence of CuI/CuIIby mechanical ball milling method. This defective HKUST-1is embellished by functionalized ionic liquids as hydrophobic armor, making the hybrid HIL1@HKUST-1 exhibits outstanding water stability,remarkable SO_(2) adsorption (up to 5.71 mmol g^(-1)), and record-breaking selectivity (1070 for SO_(2)/CO_(2) and 31,515 for SO_(2)/N_(2)) at 25 ℃ and0.1 bar, even in wet conditions.

Critical behavior of quasi-two-dimensional ferromagnet Cr_(1.04)Te_(2)

The self-intercalation of Cr into pristine two-dimensional(2D) van der Waals ferromagnetic CrTe_(2),which forms chromium tellurides(Cr_(x)Te_(2)),has garnered interest due to their remarkable magnetic characteristics and the wide variety of chemical compositions available.Here,comprehensive basic characterization and magnetic studies are conducted on quasi-2D ferromagnetic Cr_(1.04)Te_(2) crystals.Measurements of the isothermal magnetization curves are conducted around the critical temperature to systematically investigate the critical behavior.Specifically,the critical exponents β=0.2399,γ=0.859,and δ=4.3498,as well as the Curie temperature T_(C)=249.56 K,are determined using various methods,including the modified Arrott plots,the Kouvel-Fisher method,the Widom scaling method,and the critical isotherm analysis.These results indicate that the tricritical mean-field model accurately represents the critical behavior of Cr_(1.04)Te_(2.A magnetic phase diagram with tricritical phenomenon is thus constructed.Further investigations confirm that the critical exponents obtained conform to the scalar equation near T_(C),indicating their self-consistency and reliability.Our work sheds light on the magnetic properties of quasi-2D Cr_(1.04)Te_(2),broadening the scope of the van der Waals crystals for developments of future spintronic devices operable at room temperature.

A Prediction Model for Detecting Dysthyroid Optic Neuropathy Based on Clinical Factors and Imaging Markers of the Optic Nerve and Cerebrospinal Fluid in the Optic Nerve Sheath

Objective This study aimed to develop and test a model for predicting dysthyroid optic neuropathy(DON)based on clinical factors and imaging markers of the optic nerve and cerebrospinal fluid(CSF)in the optic nerve sheath.Methods This retrospective study included patients with thyroid-associated ophthalmopathy(TAO)without DON and patients with TAO accompanied by DON at our hospital.The imaging markers of the optic nerve and CSF in the optic nerve sheath were measured on the water-fat images of each patient and,together with clinical factors,were screened by Least absolute shrinkage and selection operator.Subsequently,we constructed a prediction model using multivariate logistic regression.The accuracy of the model was verified using receiver operating characteristic curve analysis.Results In total,80 orbits from 44 DON patients and 90 orbits from 45 TAO patients were included in our study.Two variables(optic nerve subarachnoid space and the volume of the CSF in the optic nerve sheath)were found to be independent predictive factors and were included in the prediction model.In the development cohort,the mean area under the curve(AUC)was 0.994,with a sensitivity of 0.944,specificity of 0.967,and accuracy of 0.901.Moreover,in the validation cohort,the AUC was 0.960,the sensitivity was 0.889,the specificity was 0.893,and the accuracy was 0.890.Conclusions A combined model was developed using imaging data of the optic nerve and CSF in the optic nerve sheath,serving as a noninvasive potential tool to predict DON.

Combined transarterial chemoembolization and tislelizumab for patients with unresectable hepatocellular carcinoma

BACKGROUND Hepatocellular carcinoma(HCC)often presents as unresectable,necessitating effective treatment modalities.Combining transarterial chemoembolization(TACE)with immunotherapy and targeted therapy has shown promise,yet real-world evidence is needed.AIM To investigate effectiveness and safety of TACE with tislelizumab±targeted therapy for unresectable HCC in real-world setting.METHODS This retrospective study included patients with unresectable HCC receiving combined treatment of TACE and tislelizumab.The clinical outcomes included progression-free survival(PFS),overall survival(OS),objective response rate(ORR),and disease control rate(DCR).All patients were evaluated according to the mRECIST criteria.The adverse event(AE)was also assessed.RESULTS In this study of 56 patients with median follow-up of 10.9 months,7 had previous immunotherapy.Tislelizumab was administered before TACE in 21(37.50%)and after in 35(62.50%)patients,with 91.07%receiving concurrent targeted therapy.Median PFS was 14.0(95%CI:7.0-18.00)months,and OS was 28(95%CI:2.94-53.05)months.Patients with prior immunotherapy had shorter PFS(6 vs.18 months,P=0.006).Overall ORR and DCR were 82.14%and 87.50%.Grade≥3 treatment-related AEs included increased alanine aminotransferase(8.93%),aspartate aminotransferase(10.71%),and total bilirubin(3.57%).CONCLUSION The combination of TACE and tislelizumab,with or without targeted therapy,demonstrated promising efficacy and safety in unresectable HCC,especially in immunotherapy-naive patients,warranting further prospective validation studies.

Study on the Efficacy of Shugan Jieyu Capsules Combined with Trazodone in Patients with Post-Stroke Depression and Insomnia

Objective:To analyze the effectiveness of applying ShuGan JieYu Capsules(SGJYC)combined with trazodone in patients with post-stroke depression(PSD)with insomnia.Methods:60 cases of PSD with insomnia patients admitted to the hospital from May 2022 to May 2023 were selected and randomly divided into a reference group(trazodone)and a research group(SGJYC combined with trazodone)of 30 cases each.Statistics were analyzed using the Hamilton Depression Rating Scale(HAM-D),Pittsburgh Sleep Quality Index(PSQI),and Activities of Daily Living(ADL)scale before treatment and 4,8,and 12 weeks after treatment.Results:Before treatment,The results of HAM-D,PSQI,and ADL scale studies in the two groups before treatment were not statistically significant(P>0.05);4,8,and 12 weeks after treatment,the results of HAM-D and PSQI studies in the research group were lower than that of the reference group,and the results of ADL scale studies were higher than that of the reference group.There was a significant difference between the groups(P<0.05).The total adverse reaction rate of the research group was lower than that of the reference group,and there was a significant difference between the groups(P<0.05).Conclusion:The combination of SGJYC and trazodone reduced depression in post-stroke patients,corrected insomnia,improved sleep quality,was safe,and had a low rate of adverse reactions.

骨科植入物无机抗菌涂层的研究现状

植入物感染是骨科最常见和最严重的并发症之一,也是导致植入手术失败的重要原因。当细菌在植入物表面形成生物膜后会极难消除,并吸附更多的细菌和真菌。大量研究表明,通过采用表面改性技术可有效减少致病菌的黏附和聚积,进而预防植入物周围感染。本文首先分析了细菌生物膜在骨科植入物表面的形成过程以及金属抗菌剂的抗菌机制。然后综述了目前国内外使用最广泛的一些金属基无机抗菌涂层及其相关的制备工艺,讨论了这些涂层在应用中存在的问题和改善方法,并展望了未来无机抗菌涂层的发展方向,包括协同抗菌型涂层和促成骨型抗菌涂层等。

Multiple omics datasets reveal significant physical and physiological dormancy in alfalfa hard seeds identified by multispectral imaging analysis

Physical dormancy(PY) commonly present in the seeds of higher plants is believed to be responsible for the germination failure by impermeable seed coat in hard seeds of legume species, instead of physiological dormancy(PD). In this study, a non-destructive approach involving multispectral imaging was used to successfully identify hard seeds from non-hard seeds in Medicago sativa, with accuracy as high as96.8%–99.0%. We further adopted multiple-omics strategies to investigate the differences of physiology,metabolomics, methylomics, and transcriptomics in alfalfa hard seeds, with non-hard seeds as control.The hard seeds showed dramatically increased antioxidants and 125 metabolites of significant differences in non-targeted metabolomics analysis, which are enriched in the biosynthesis pathways of flavonoids, lipids and hormones, especially with significantly higher ABA, a hormone known to induce dormancy. In our transcriptomics results, the enrichment pathway of “response to abscisic acid” of differential expressed genes(DEG) supported the key role of ABA in metabolomics results. The methylome analysis identified 54,899, 46,216 and 54,452 differential methylation regions for contexts of CpG, CHG and CHH, and 344 DEGs might be regulated by hypermethylation and hypomethylation of promoter and exon regions, including four ABA-and JA-responsive genes. Among 8% hard seeds in seed lots,24.5% still did not germinate after scarifying seed coat, and were named as non-PY hard seeds.Compared to hard seeds, significantly higher contents of ABA/IAA and ABA/JA were identified in nonPY hard seeds, which indicated the potential presence of PD. In summary, the significantly changed metabolites, gene expressions, and methylations all suggested involvement of ABA responses in hard seeds, and germination failure of alfalfa hard seeds was caused by combinational dormancy(PY + PD),rather than PY alone.

Upregulation of histone H3 caused by CRYAA may contribute to the development of age-related cataract

Objective:Age-relate cataract(ARC)is a disease of the eyes with no effective drugs to prevent or treat patients.The aim of the present study is to determine whether histone H3,αA-crystallin(CRYAA),β-galactosidase(GLB1),and p53 are involved in the pathogenesis of ARC.Methods:A total of 99 anterior lens capsules(ALCs)of patients with ARC of various nuclear grades,ultraviolet models of ALCs,and two human lens epithelial cell lines(FHL-124 and SRA01/04)were used,and the expression of histone H3,CRYAA,GLB1,and p53 were detected by immunoblotting and reverse transcription and real time-quantitative polymerase chain reaction.The association between CRYAA with histone H3,GLB1,and p53 was assessed in FHL-124 and SRA01/04 cells following CRYAA overexpression.Results:Histone H3 and p53 in ALCs of patients with ARC were up-regulated in a grade-dependent manner,and the expression of CRYAA showed a positive association with histone H3,p53,and GLB1.In UV models of ALCs and human lens epithelial cell lines,the expression levels of histone H3,cell apoptosis factors(Bax/Bcl-2,cleaved caspase-3),and inflammation factors(interleukin-6,tumor necrosis factor-α)were all up-regulated.Furthermore,transfection of CRYAA in FHL-124 cells induced overexpression of histone H3.Conclusion:CRYAA-mediated upregulation of histone H3 may be involved in the pathogenesis of ARC.p53 may also have a role in ARC development,but not via the CRYAA-histone H3 axis.The results of the present study may assist in improving our understanding of the pathogenesis of ARC and in identifying potential targets for treatment.

Comparisons between Isotropic and Anisotropic TV Regularizations in Inverse Acoustic Scattering

This article compares the isotropic and anisotropic TV regularizations used in inverse acoustic scattering. It is observed that compared with the traditional Tikhonov regularization, isotropic and anisotropic TV regularizations perform better in the sense of edge preserving. While anisotropic TV regularization will cause distortions along axes. To minimize the energy function with isotropic and anisotropic regularization terms, we use split Bregman scheme. We do several 2D numerical experiments to validate the above arguments.

耳内镜下经耳道鼓室成形手术的可行性分析

目的探讨全耳内镜下经耳道鼓室成形手术疗效及可行性.方法回顾性分析2016年2月-2017年10月收治的100例慢性化脓性中耳炎和鼓室胆脂瘤患者,同期行经耳道全耳内镜鼓室探查、鼓室病灶清除加鼓室成形手术,观察术后鼓膜形态恢复情况及愈合率,并比较手术前与手术后3个月平均气导听阈(PTA)及气骨导差(A^B gap)的差异.结果 100例患者术后鼓膜一期完全愈合96例(96%),遗留小穿孔4例(4%),均在门诊耳内镜下处理后完全愈合,内镜下见鼓膜形态良好.术前平均气导听阈为(43.45±9.56)dB/HL,术后平均气导听阈为(27.23±6.89)dB/HL,术前术后比较,差异有统计学意义(P<0.01).术前平均气骨导差为(28.42±6.78)dB/HL,术后平均气骨导差为(13.62±8.67)dB/HL,术前术后比较,差异有统计学意义(P<0.01).结论全耳内镜下经耳道探查处理中耳病灶的同时,行鼓室成形是一种安全有效的手术方法,耳内镜具有视野广及清晰、创伤小、恢复快及听力效果良好和并发症少等优点,具有良好的可行性,是未来中耳手术的一个热点及方向.

A Novel Cuckoo Search Algorithm and Its Application

In this paper, the principle of Cuckoo algorithm is introduced, and the traditional Cuckoo algorithm is improved to establish a mathematical model of multi-objective optimization scheduling. Based on the improved algorithm, the model is optimized to a certain extent. Through analysis, it is proved that the improved algorithm has higher computational accuracy and can effectively improve the global convergence.

The Mechanical Characteristics and Experimental Study of the Stratospheric Airship

Stratospheric airship is a special near-space air vehicle which has lots of advantages than other traditional flying aircrafts, such as long endurance, strong survival ability, low cost, excellent resolution detector etc. In addition, the stratospheric airship can be an ideal stratospheric bearing platform. This paper firstly gave an overview describing some technical differences between the stratospheric airship and the traditional airship, including the working environment, design specifications, structure characteristics, energy system, flying modes, and so on. Some technical difficulties including the materials, power system which apply to the stratospheric airship and deformation of the huge hull, super-heating effect, and station-keeping were discussed. Furthermore, technical target, technical specifications, design concept, and overview of flying tested about two stratospheric demonstration airships which were representative achievements of the research on the stratospheric airship in China were introduced. Finally, the predictions about the progress and direction of development were discussed.

主动健康教育对江油市农村≥65岁老年人口结核病防治知识知晓率的效果分析

目的评价开展多形式主动健康教育对农村地区老年人结核病防治核心知识知晓情况的效果。方法本次研究在2013—2014年结合四川省江油市基本公共卫生服务年度体检项目工作开展2次基线调查时进行。采用整群随机抽样方法抽取江油市的3个农村乡镇(重华镇、厚坝镇、二郎庙镇)为调查点,于2013年7月至2014年7月开展结核病全乡镇多种方式的公众健康宣传教育,采用横断面调查的方法,在面对面入户基线调查前、干预实施1年后,使用统一设计的历年结核病基线调查采用的结核病防治核心知识知晓率问卷对调查点≥65岁常住老年人进行面对面询问调查,以了解干预前后的核心知识知晓情况。结果结核病核心知识总知晓率干预后(54.66%,15727/28775)较干预前(10.31%,3053/29640)提高了44.35%(χ2=13168.16,P<0.001);全部知晓率干预后(14.56%,838/5755)较干预前(1.55%,92/5928)提高了13.01%(χ2=674.53,P<0.001)。男性结核病核心知识总知晓率干预前[12.14%,1766/(2909×5)]、干预后[56.95%,7987/(2805×5)]均高于女性[分别为8.53%,1287/(3019×5);52.47%,7740/(2950×5)](χ2=104.81,P<0.05;χ2=58.06,P<0.05);干预前后男性提高了44.81%(χ2=6375.64,P<0.001),女性提高了43.94%(χ2=6829.73,P<0.001)。结论通过主动开展健康教育能够提高农村地区≥65岁老年人对结核病核心知识的知晓率,促进和改善农村地区老年结核病主动发现的防治工作,是农村地区老年结核病患者提高结核病防治知识的一种不可缺少的重要手段。

TERT基因单核苷酸多态性与年龄相关性黄斑变性的关联研究

目的:探讨端粒酶逆转录酶(TERT)基因单核苷酸多态性(SNP)与年龄相关性黄斑变性(ARMD)发生风险的关联性。方法:采用高通量基因质谱技术检测191例ARMD患者(病例组)和197例健康体检者(对照组)TERT基因7个已报道的与端粒长度有关的SNP位点,通过Logistic回归评估其等位基因、基因型与ARMD发病风险的关系。结果:TERT基因SNP位点rs10069690基因型CC、CT、TT在病例组和对照组受检者中的分布频率分别为64.4%、31.4%、4.2%和74.6%、22.8%、2.5%,人群分布存在显著差异;携带CT+TT基因型的人群发生ARMD的风险显著增加(OR=1.63,95%CI 1.05~2.53)。结论:TERT基因SNP位点rs10069690与ARMD发病风险存在显著关联。

Catquest-8SF量表分析年龄相关性白内障患者的效果（英文）

目的:应用Catquest-8SF量表研究PHACO+SIOL植入术患者主观报告的效果,评估Catquest-8SF量表在中国北方白内障人群的适用性及其对白内障手术的敏感性。方法:前瞻性临床病例随访研究。泰安市中心医院白内障患者术前和术后3mo完成面对面的Catquest-8SF量表填写。结果:术前共120例白内障患者完成了Catquest-8SF量表。术前Catquest-8SF量表得分与术前双眼加权logMAR视力及年龄呈显著负相关(P<0. 05),与文化程度呈正相关(P<0. 001),无全身合并症的患者量表得分高于有全身合并症的患者(P<0. 05)。102名(85%)患者完成术后3mo量表,单眼手术组和双眼手术组比较,术后视力均显著提高(t=10. 404,P<0. 001),术后量表得分均明显提高(P<0. 001)。两组在量表得分提高值上差异无统计学意义。92. 2%的患者对手术效果满意。满意度与量表得分的提高值显著相关(P<0. 05)。结论:中文版Catquest-8SF量表在我国北方ARC人群中适用性好,简短高效,可以作为白内障常规临床评估的一部分。