目的分析三维重建技术在腹腔镜肝切除术中的应用效果。方法回顾性分析湖北医药学院附属十堰市太和医院2017年7月至2019年7月收治的86例原发性肝癌患者临床资料。根据是否行三维重建技术将患者分为观察组(n=44)和对照组(n=42),记录并比...目的分析三维重建技术在腹腔镜肝切除术中的应用效果。方法回顾性分析湖北医药学院附属十堰市太和医院2017年7月至2019年7月收治的86例原发性肝癌患者临床资料。根据是否行三维重建技术将患者分为观察组(n=44)和对照组(n=42),记录并比较两组手术患者的一般情况、手术时间、术中出血量、平均住院时间、术后并发症情况。在术前及术后7 d检测并比较两组患者血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、白蛋白(ALB)和甲胎蛋白(AFP)含量变化。结果观察组手术时间、术中出血量、术后住院时间均优于对照组,差异均具有统计学意义(P<0.05);两组患者术前ALT、AST、TBIL、AFP、ALB含量均无明显差异(P>0.05)。观察组术后7 d ALT、AST、TBIL、AFP含量均低于对照组术后,ALB含量高于对照组术后,且差异均具有统计学意义(P<0.05)。观察组术后并发症较对照组显著降低(P<0.05)。结论三维重建技术应用于腹腔镜肝切除术能够缩短手术时间,减少术中出血量,降低住院时间,改善肝功能,减少术后并发症发生,从而加快患者恢复,确保手术安全,值得在地市级三甲医院推广及应用。展开更多
Characteristic town has became an important carrier for urban-mral integration. Based on the multiple compounding of the charactemtic town planning, it is significant to combine tiie universal viewpoint widi tradit...Characteristic town has became an important carrier for urban-mral integration. Based on the multiple compounding of the charactemtic town planning, it is significant to combine tiie universal viewpoint widi traditional small town planning. This paper by combining with “universaT viewpoint introduced the transformation of traditional small town planning in theory and practice, and combed the planning stategies from the 4 a^ects of “all level”,“all space”, “all element^,and “all dimension”. Based on the master plan of Guzhu Town in Heyuan, specific strategies were put forward from the 6 dimensions of resoutce analysis, spatial layout, industtiai construction, traffic connection, ecological control and system update, to provide references for the planning of characteristic towns.展开更多
Internet Plus is an important opportunity for economic transformation.At present,the research for Internet Plus in China that focuses on e-commerce,industrial networks,and Internet banking gives priority to the buildi...Internet Plus is an important opportunity for economic transformation.At present,the research for Internet Plus in China that focuses on e-commerce,industrial networks,and Internet banking gives priority to the building of virtual Internet platform and lacks the integration of physical space design.In the context of Internet Plus,urban design of Hipark in Xiaoshan District,Hangzhou adheres to the principals of building the incubator space and services platform,creating urban space environment with distinctive characteristics,and planning sustainable development policies.Furthermore,through the carrier of ispace,the featured context of water towns,and groups of block units,it can carry new industrial capabilities,create diverse living environment,and establish urban growth patterns,in order to make exploratory practice for the integration of Internet Plus with urban design at spatial level in China.展开更多
Catalytic therapy based on piezoelectric nanoparticles has become one of the effective strategies to eliminate tumors.However,it is still a challenge to improve the tumor delivery efficiency of piezoelectric nanoparti...Catalytic therapy based on piezoelectric nanoparticles has become one of the effective strategies to eliminate tumors.However,it is still a challenge to improve the tumor delivery efficiency of piezoelectric nanoparticles,so that they can penetrate normal tissues while specifically aggregating at tumor sites and subsequently generating large amounts of reactive oxygen species(ROS)to achieve precise and efficient tumor clearance.In the present study,we successfully fabricated tumor microenvironment-responsive assembled barium titanate nanoparticles(tma-BTO NPs):in the neutral pH environment of normal tissues,tma-BTO NPs were monodisperse and possessed the ability to cross the intercellular space;whereas,the acidic environment of the tumor triggered the self-assembly of tma-BTO NPs to form submicron-scale aggregates,and deposited in the tumor microenvironment.The self-assembled tma-BTO NPs not only caused mechanical damage to tumor cells;more interestingly,they also exhibited enhanced piezoelectric catalytic efficiency and produced more ROS than monodisperse nanoparticles under ultrasonic excitation,attributed to the mutual extrusion of neighboring particles within the confined space of the assembly.tma-BTO NPs exhibited differential cytotoxicity against tumor cells and normal cells,and the stronger piezoelectric catalysis and mechanical damage induced by the assemblies resulted in significant apoptosis of mouse breast cancer cells(4T1);while there was little damage to mouse embryo osteoblast precursor cells(MC3T3-E1)under the same treatment conditions.Animal experiments confirmed that peritumoral injection of tma-BTO NPs combined with ultrasound therapy can effectively inhibit tumor progression non-invasively.The tumor microenvironment-responsive self-assembly strategy opens up new perspectives for future precise piezoelectric-catalyzed tumor therapy.展开更多
As a traditional Chinese herbal medicine, Pulsatilla Chinensis(P. Chinensis) is widely used in the clinical practice of traditional Chinese medicine(TCM). Recently, medical research has found that the natural product ...As a traditional Chinese herbal medicine, Pulsatilla Chinensis(P. Chinensis) is widely used in the clinical practice of traditional Chinese medicine(TCM). Recently, medical research has found that the natural product P. Chinensis saponins and their monomeric compounds extracted from P. Chinensis have a variety of biological activities, especially the triterpenoid saponins, which have significant and broad-spectrum anti-tumor effects. Moreover, its anti-tumor molecular mechanisms include inhibition of the growth and proliferation of tumor cells, repression of the migration, invasion, and metastasis, prevention of tumor cell cycle, regulation of cancer cell energy metabolism, anti-tumor angiogenesis, induction of cancer cell differentiation, apoptosis and autophagy, reversing cancer cell resistance, regulation a variety of related signaling pathways, and improvement of the inflammatory microenvironment of tumor cells. In the present work, we reviewed the related anticancer mechanisms of P. Chinensis saponins and their monomers in different tumors, aiming to provide a theoretical basis for the development and clinical application of new anti-tumor drugs of P. Chinensis saponins and their monomeric compounds.展开更多
文摘目的分析三维重建技术在腹腔镜肝切除术中的应用效果。方法回顾性分析湖北医药学院附属十堰市太和医院2017年7月至2019年7月收治的86例原发性肝癌患者临床资料。根据是否行三维重建技术将患者分为观察组(n=44)和对照组(n=42),记录并比较两组手术患者的一般情况、手术时间、术中出血量、平均住院时间、术后并发症情况。在术前及术后7 d检测并比较两组患者血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、白蛋白(ALB)和甲胎蛋白(AFP)含量变化。结果观察组手术时间、术中出血量、术后住院时间均优于对照组,差异均具有统计学意义(P<0.05);两组患者术前ALT、AST、TBIL、AFP、ALB含量均无明显差异(P>0.05)。观察组术后7 d ALT、AST、TBIL、AFP含量均低于对照组术后,ALB含量高于对照组术后,且差异均具有统计学意义(P<0.05)。观察组术后并发症较对照组显著降低(P<0.05)。结论三维重建技术应用于腹腔镜肝切除术能够缩短手术时间,减少术中出血量,降低住院时间,改善肝功能,减少术后并发症发生,从而加快患者恢复,确保手术安全,值得在地市级三甲医院推广及应用。
文摘Characteristic town has became an important carrier for urban-mral integration. Based on the multiple compounding of the charactemtic town planning, it is significant to combine tiie universal viewpoint widi traditional small town planning. This paper by combining with “universaT viewpoint introduced the transformation of traditional small town planning in theory and practice, and combed the planning stategies from the 4 a^ects of “all level”,“all space”, “all element^,and “all dimension”. Based on the master plan of Guzhu Town in Heyuan, specific strategies were put forward from the 6 dimensions of resoutce analysis, spatial layout, industtiai construction, traffic connection, ecological control and system update, to provide references for the planning of characteristic towns.
文摘Internet Plus is an important opportunity for economic transformation.At present,the research for Internet Plus in China that focuses on e-commerce,industrial networks,and Internet banking gives priority to the building of virtual Internet platform and lacks the integration of physical space design.In the context of Internet Plus,urban design of Hipark in Xiaoshan District,Hangzhou adheres to the principals of building the incubator space and services platform,creating urban space environment with distinctive characteristics,and planning sustainable development policies.Furthermore,through the carrier of ispace,the featured context of water towns,and groups of block units,it can carry new industrial capabilities,create diverse living environment,and establish urban growth patterns,in order to make exploratory practice for the integration of Internet Plus with urban design at spatial level in China.
基金supported by National Key Research and Development Program of China(2022YFE0111700,2021YFB3201204)the National Natural Science Foundation of China(T2125003,52372174)+2 种基金the open project of State Drug Administration Key Laboratory of Oral Materials(PKUSS20210401)the Beijing Natural Science Foundation(JQ20038,L212010)the Fundamental Research Funds for the Central Universities,and the Scientific Research Project of Guangdong Provincial Education Department(2022KTSCX118).
文摘Catalytic therapy based on piezoelectric nanoparticles has become one of the effective strategies to eliminate tumors.However,it is still a challenge to improve the tumor delivery efficiency of piezoelectric nanoparticles,so that they can penetrate normal tissues while specifically aggregating at tumor sites and subsequently generating large amounts of reactive oxygen species(ROS)to achieve precise and efficient tumor clearance.In the present study,we successfully fabricated tumor microenvironment-responsive assembled barium titanate nanoparticles(tma-BTO NPs):in the neutral pH environment of normal tissues,tma-BTO NPs were monodisperse and possessed the ability to cross the intercellular space;whereas,the acidic environment of the tumor triggered the self-assembly of tma-BTO NPs to form submicron-scale aggregates,and deposited in the tumor microenvironment.The self-assembled tma-BTO NPs not only caused mechanical damage to tumor cells;more interestingly,they also exhibited enhanced piezoelectric catalytic efficiency and produced more ROS than monodisperse nanoparticles under ultrasonic excitation,attributed to the mutual extrusion of neighboring particles within the confined space of the assembly.tma-BTO NPs exhibited differential cytotoxicity against tumor cells and normal cells,and the stronger piezoelectric catalysis and mechanical damage induced by the assemblies resulted in significant apoptosis of mouse breast cancer cells(4T1);while there was little damage to mouse embryo osteoblast precursor cells(MC3T3-E1)under the same treatment conditions.Animal experiments confirmed that peritumoral injection of tma-BTO NPs combined with ultrasound therapy can effectively inhibit tumor progression non-invasively.The tumor microenvironment-responsive self-assembly strategy opens up new perspectives for future precise piezoelectric-catalyzed tumor therapy.
基金The National Natural Science Foundation of China (Grant No. 81703768 and 81803400)the Natural Science Foundation of Shandong Province (Grant No. ZR2017MH118 and ZR2018BH045)。
文摘As a traditional Chinese herbal medicine, Pulsatilla Chinensis(P. Chinensis) is widely used in the clinical practice of traditional Chinese medicine(TCM). Recently, medical research has found that the natural product P. Chinensis saponins and their monomeric compounds extracted from P. Chinensis have a variety of biological activities, especially the triterpenoid saponins, which have significant and broad-spectrum anti-tumor effects. Moreover, its anti-tumor molecular mechanisms include inhibition of the growth and proliferation of tumor cells, repression of the migration, invasion, and metastasis, prevention of tumor cell cycle, regulation of cancer cell energy metabolism, anti-tumor angiogenesis, induction of cancer cell differentiation, apoptosis and autophagy, reversing cancer cell resistance, regulation a variety of related signaling pathways, and improvement of the inflammatory microenvironment of tumor cells. In the present work, we reviewed the related anticancer mechanisms of P. Chinensis saponins and their monomers in different tumors, aiming to provide a theoretical basis for the development and clinical application of new anti-tumor drugs of P. Chinensis saponins and their monomeric compounds.
