Visual analysis of the research situation of corona virus disease 2019

Objective:To understand the research status of corona virus disease 2019(COVID-19),analyze research hotspots and dynamic frontiers,and provide ideas for the research of COVID-19.Methods:Bibliometrics method was used to retrieve documents related to COVID-19 research through China National Knowledge Infrastructure,Web of Science,Pubmed databases,and the number of literature data,author,country,institution,source,keywords using CiteSpace,SPSS,Excel perform statistical analysis on other aspects,explain the current status and development trend of new coronavirus pneumonia research,and analyze and identify the research hotspots and dynamic frontiers of COVID-19 through the visual presentation of knowledge graph.Results:With the global spread of the new coronavirus pneumonia epidemic,a large number of studies on COVID-19 have been performed worldwide.In this paper,a total of 7,647 articles were retrieved through a database search,and 5,182 documents that met the criteria were selected for bibliographic analysis,including 2,388 Chinese documents.Articles,2,794 English literature,a total of 94 countries,3,985 institutions,10,339 authors participated in the relevant research of COVID-19,involving 999 kinds of journals,the Chinese scientific research team played a major role in the COVID-19 research,providing an important epidemic situation related research results.Conclusion:The current research focus is primarily on disease recognition,epidemic prevention and control,traditional Chinese medicine,clinical diagnosis and treatment,and epidemiology.

Network pharmacology study on mechanism of Zhen-Wu decoctionfor chronic heart failure treatment

Background:To explore and predict the mechanism of classic ancient prescription of Chinese medicine Zhen-Wu decoction for chronic heart failure treatment based on network pharmacology.Methods:Traditional Chinese medicine systems pharmacology database was used to search the effective components and targets of herbs in classic ancient prescription of Chinese medicine Zhen-Wu decoction.Relevant target genes of chronic heart failure were obtained from GeneCards and Online Mendelian Inheritance in Man databases.Then we obtained the intersection target genes of classic ancient prescription of Chinese medicine Zhen-Wu decoction in treating chronic heart failure,constructing the classic ancient prescription of Chinese medicine Zhen-Wu decoction-active ingredient-chronic heart failure-targets network using Cytoscape,and performing network analysis using a network ananlyzer plug-in to acquire hub compounds and key targets.Proton pump inhibitor network was constructed through STRING database.Gene ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were carried out in Database for Annotation,Visualization and Integrated Discovery.Results:There are 61 active ingredients and 134 action targets in classic ancient prescription of Chinese medicine Zhen-Wu decoction,among which 49 target genes and 11 important compounds related to the chronic heart failure treatment.After network analysis,we obtained 12 key targets,77 gene ontology entries and 22 signal pathways,including tumor necrosis factor signaling pathway,NF-kappaB signal pathway,PI3K-Akt signal pathway,et al.Concludion:classic ancient prescription of Chinese medicine Zhen-Wu decoction was used for chronic heart failure treatment for the multi-component,multi-target and multi-channel interaction.The components such as kaempferol andβ-sitosterol were combined with target proteins such as CHRM1 and AChE,involving biological processes such as DNA transcription regulation,cholinergic synaptic transmission and apoptosis regulation,as well as signal pathways such as tumor necrosis factor signaling pathway,NF-kappaB signal pathway,PI3K-Akt signal pathway,et al.