背景:膜片钳技术作为研究离子通道的“金标准”,已有40多年的发展历史。然而,科研机构的研究内容相对独立,没有对现有研究成果进行系统总结,导致现有研究存在重复性高、创新性弱的现象。因此,急需对膜片钳技术做一个全面的回顾,以明晰...背景:膜片钳技术作为研究离子通道的“金标准”,已有40多年的发展历史。然而,科研机构的研究内容相对独立,没有对现有研究成果进行系统总结,导致现有研究存在重复性高、创新性弱的现象。因此,急需对膜片钳技术做一个全面的回顾,以明晰现今的研究现状、热点和未来发展方向。目的:总结近10年膜片钳技术领域的研究现状和发展趋势。方法:使用Web of Science核心合集数据库收集了2013-2023年关于膜片钳技术的出版物。采用CiteSpace和VOSviewer软件对出版物数量进行量化分析,并分析文献条目网络,包括国家、机构、期刊、作者、关键词、高被引文献和共被引参考文献。结果与结论:①近10年间,膜片钳技术领域研究已逐步进入稳定发展阶段。②中国和美国是这方面的领先国家,中国科学院是具有核心影响力的机构,《Journal of Neuroscience》是主要出版刊物,PARK,WON SUN团队(韩国全北国立大学)和CHU,LI团队(中国河北省心脑血管病中医药防治研究重点实验室)在该领域作出了杰出的贡献,但团队之间的协作与交流较少,尚未形成网络合作模式。③膜片钳技术主要应用在神经系统的电生理特性及其疾病的病理机制方面,是研究人员持续关注的焦点。④在心血管系统电生理特性及其疾病病理机制的研究方面,对原代心肌细胞、诱导多能干细胞衍生的心肌细胞的电生理特性和心房颤动、心脏毒性、心源性猝死和高血压等心血管疾病的病理机制方面的研究,是近几年来研究的热点。⑤在膜片钳技术与其他生物技术的结合应用方面,关注的是与光遗传学、双光子钙成像等技术的交叉融合,将是一个重要的研究方向。⑥在药物筛选及治疗靶点的识别研究方面,尤其对于膜片钳技术和中药复方的研究,将成为未来组分中药研究中的一大助力。展开更多
土地利用变化通过影响土壤中有机碳的分布和储量,尤其是林地、草地与耕地之间相互转化时会伴随着碳交换的过程,从而影响着温室气体的排放以及陆地碳储量。目前,土地利用变化与碳储量的关系已成为研究热点,为了探究该领域的研究现状和研...土地利用变化通过影响土壤中有机碳的分布和储量,尤其是林地、草地与耕地之间相互转化时会伴随着碳交换的过程,从而影响着温室气体的排放以及陆地碳储量。目前,土地利用变化与碳储量的关系已成为研究热点,为了探究该领域的研究现状和研究趋势,本文对Web of Science上收录的2014~2024年的文献借助Cite Space软件针对发文量、研究国家、机构、作者、关键词进行整理汇总分析。结论显示,当前该领域的研究热点为生命周期评价、土壤有机质(有机碳)、碳汇、数字土壤制图;而未来的研究可能更倾向于多学科交叉、多尺度集成、高精度模拟和动态评估等技术或研究方法深度探究土地利用对碳储量的定量影响,即如何结合国家政策及国内外研究现状选择合适的研究方法从微观尺度对该研究领域进行精细化定量研究,进而更好地对土地利用加以管理,实现环境可持续发展。展开更多
Parasites have coexisted with humans throughout history,forming either symbiotic relationships or causing significant morbidity and mortality.The liver is particularly vulnerable to parasitic infections,which can resi...Parasites have coexisted with humans throughout history,forming either symbiotic relationships or causing significant morbidity and mortality.The liver is particularly vulnerable to parasitic infections,which can reside in,pass through,or be transported to the liver,leading to severe damage.This editorial explores various parasites that infect the liver,their clinical implications,and diagnostic considerations,as discussed in the article“Parasites of the liver:A global problem?”.Parasites reach the liver primarily through oral ingestion,mucosal penetration,or the bloodstream,with some larvae even penetrating the skin.Hepatic parasites such as cestodes(Echinococcus),trematodes(Clonorchis,Opisthorchis),nematodes(Ascaris),and protozoa(Entamoeba histolytica)can also cause systemic infections like visceral leishmaniasis,malaria,cryptosporidiosis,and toxoplasmosis.Chronic infections like clonorchiasis and opisthorchiasis are linked to persistent hepatobiliary inflammation,potentially progressing to cholangiocarcinoma,a fatal bile duct cancer,particularly prevalent in Southeast Asia.The global nature of liver parasite infestations is alarming,with hundreds of millions affected worldwide.However,control over treatment quality remains suboptimal.Given the significant public health threat posed by these parasites,international medical organizations must prioritize improved diagnosis,treatment,and preventive measures.Strengthening educational efforts and enhancing healthcare provider training are critical steps toward mitigating the global impact of parasitic liver diseases.展开更多
为全面了解国内外关于菊粉的主要研究现状与研究热点,推测菊粉未来研究的发展趋势。该研究选取2013—2022年Web of Science(WOS)核心合集数据库英文文献、中国知网(China National Knowledge Infrastructure, CNKI)数据库中文文献作为...为全面了解国内外关于菊粉的主要研究现状与研究热点,推测菊粉未来研究的发展趋势。该研究选取2013—2022年Web of Science(WOS)核心合集数据库英文文献、中国知网(China National Knowledge Infrastructure, CNKI)数据库中文文献作为数据样本,利用CiteSpace可视化软件对所选数据的发表期刊、作者、机构、国家和关键词等进行可视化分析,同时增加关键词的聚类和突现词可视化分析,总结国内外菊粉研究的现状。结果表明,菊粉领域的研究受到越来越多的关注,发文量呈上升趋势。国内期刊和国外期刊发文量最多的分别是《食品工业科技》和LWT—Food Science and Technology。WOS核心合集数据库中发文量前10的作者中有6位是中国学者,CNKI数据库和WOS核心合集数据库中文献发文量前10的机构均包含中国科学院、江南大学和中国科学院大学;从WOS核心合集数据库来看多个国家对菊粉展开了研究,中国发文量最多(890篇),可见中国对菊粉研究作出了巨大贡献。不同作者和机构间虽有合作,但研究领域较为分散、合作还不够密切。CNKI数据库和WOS核心合集数据库关键词分析可以看出研究大多是以菊粉的益生元功效展开探索,并重视菊粉在食品领域的应用;突现词分析表明菊粉稳定性、协同作用、生物活性等是当下研究的热点。菊粉发展潜力巨大,在食品和医药领域的开发将成为未来研究的趋势,尤其是以菊粉为原料进行食品研发,同时将菊粉用于药物递送载体、药物稳定剂、疫苗佐剂等将成为未来研究的重点。整体而言,该研究为菊粉未来的研究与开发提供了数据支撑。展开更多
BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood swings.Effective drug treatment modalities are crucial for managing BD.AIM To analyze the current status and future trends of...BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood swings.Effective drug treatment modalities are crucial for managing BD.AIM To analyze the current status and future trends of global research on BD drug treatment over the last decade.METHODS The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were extracted.Data visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration networks.The University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this field.The Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited paper.CONCLUSION This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future directions.The study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.展开更多
BACKGROUND With the growing scholarly and clinical fascination with somatic symptom dis-order(SSD),a bibliometric analysis is lacking.AIM To conduct a bibliometric analysis to investigate the current status and fronti...BACKGROUND With the growing scholarly and clinical fascination with somatic symptom dis-order(SSD),a bibliometric analysis is lacking.AIM To conduct a bibliometric analysis to investigate the current status and frontiers of SSD.METHODS The documents related to SSD are obtained from the web of science core collection database(WoSCC),and VOSviewer 1.6.16 from January 1,2000 to December 31,2023,and the WoSCC’s literature analysis wire were used to conduct the biblio-metric analysis.RESULTS A total of 567 documents related to SSD were included,and 2325 authors across 947 institutions from 57 countries/regions have contributed to SSD research,published in 277 journals.The most productive author,institution,country and journal were Löwe B,University of Hamburg,Germany,and Journal of Psycho-somatic Research respectively.The first high-cited document was published in the Journal of Psychosomatic Research in 2013 by Dimsdale JE and colleagues,which explored the rationale behind the SSD diagnosis introduction in diagnostic and statistical manual of mental disorders.CONCLUSION In conclusion,the main research hotspots and frontiers in the field of SSD are validity and reliability of the SSD criteria,functional impairment of SSD,and the treatment for SSD.More high-quality studies are needed to assess the diagnosis and treatment of SSD.展开更多
文摘背景:膜片钳技术作为研究离子通道的“金标准”,已有40多年的发展历史。然而,科研机构的研究内容相对独立,没有对现有研究成果进行系统总结,导致现有研究存在重复性高、创新性弱的现象。因此,急需对膜片钳技术做一个全面的回顾,以明晰现今的研究现状、热点和未来发展方向。目的:总结近10年膜片钳技术领域的研究现状和发展趋势。方法:使用Web of Science核心合集数据库收集了2013-2023年关于膜片钳技术的出版物。采用CiteSpace和VOSviewer软件对出版物数量进行量化分析,并分析文献条目网络,包括国家、机构、期刊、作者、关键词、高被引文献和共被引参考文献。结果与结论:①近10年间,膜片钳技术领域研究已逐步进入稳定发展阶段。②中国和美国是这方面的领先国家,中国科学院是具有核心影响力的机构,《Journal of Neuroscience》是主要出版刊物,PARK,WON SUN团队(韩国全北国立大学)和CHU,LI团队(中国河北省心脑血管病中医药防治研究重点实验室)在该领域作出了杰出的贡献,但团队之间的协作与交流较少,尚未形成网络合作模式。③膜片钳技术主要应用在神经系统的电生理特性及其疾病的病理机制方面,是研究人员持续关注的焦点。④在心血管系统电生理特性及其疾病病理机制的研究方面,对原代心肌细胞、诱导多能干细胞衍生的心肌细胞的电生理特性和心房颤动、心脏毒性、心源性猝死和高血压等心血管疾病的病理机制方面的研究,是近几年来研究的热点。⑤在膜片钳技术与其他生物技术的结合应用方面,关注的是与光遗传学、双光子钙成像等技术的交叉融合,将是一个重要的研究方向。⑥在药物筛选及治疗靶点的识别研究方面,尤其对于膜片钳技术和中药复方的研究,将成为未来组分中药研究中的一大助力。
文摘土地利用变化通过影响土壤中有机碳的分布和储量,尤其是林地、草地与耕地之间相互转化时会伴随着碳交换的过程,从而影响着温室气体的排放以及陆地碳储量。目前,土地利用变化与碳储量的关系已成为研究热点,为了探究该领域的研究现状和研究趋势,本文对Web of Science上收录的2014~2024年的文献借助Cite Space软件针对发文量、研究国家、机构、作者、关键词进行整理汇总分析。结论显示,当前该领域的研究热点为生命周期评价、土壤有机质(有机碳)、碳汇、数字土壤制图;而未来的研究可能更倾向于多学科交叉、多尺度集成、高精度模拟和动态评估等技术或研究方法深度探究土地利用对碳储量的定量影响,即如何结合国家政策及国内外研究现状选择合适的研究方法从微观尺度对该研究领域进行精细化定量研究,进而更好地对土地利用加以管理,实现环境可持续发展。
文摘Parasites have coexisted with humans throughout history,forming either symbiotic relationships or causing significant morbidity and mortality.The liver is particularly vulnerable to parasitic infections,which can reside in,pass through,or be transported to the liver,leading to severe damage.This editorial explores various parasites that infect the liver,their clinical implications,and diagnostic considerations,as discussed in the article“Parasites of the liver:A global problem?”.Parasites reach the liver primarily through oral ingestion,mucosal penetration,or the bloodstream,with some larvae even penetrating the skin.Hepatic parasites such as cestodes(Echinococcus),trematodes(Clonorchis,Opisthorchis),nematodes(Ascaris),and protozoa(Entamoeba histolytica)can also cause systemic infections like visceral leishmaniasis,malaria,cryptosporidiosis,and toxoplasmosis.Chronic infections like clonorchiasis and opisthorchiasis are linked to persistent hepatobiliary inflammation,potentially progressing to cholangiocarcinoma,a fatal bile duct cancer,particularly prevalent in Southeast Asia.The global nature of liver parasite infestations is alarming,with hundreds of millions affected worldwide.However,control over treatment quality remains suboptimal.Given the significant public health threat posed by these parasites,international medical organizations must prioritize improved diagnosis,treatment,and preventive measures.Strengthening educational efforts and enhancing healthcare provider training are critical steps toward mitigating the global impact of parasitic liver diseases.
文摘为全面了解国内外关于菊粉的主要研究现状与研究热点,推测菊粉未来研究的发展趋势。该研究选取2013—2022年Web of Science(WOS)核心合集数据库英文文献、中国知网(China National Knowledge Infrastructure, CNKI)数据库中文文献作为数据样本,利用CiteSpace可视化软件对所选数据的发表期刊、作者、机构、国家和关键词等进行可视化分析,同时增加关键词的聚类和突现词可视化分析,总结国内外菊粉研究的现状。结果表明,菊粉领域的研究受到越来越多的关注,发文量呈上升趋势。国内期刊和国外期刊发文量最多的分别是《食品工业科技》和LWT—Food Science and Technology。WOS核心合集数据库中发文量前10的作者中有6位是中国学者,CNKI数据库和WOS核心合集数据库中文献发文量前10的机构均包含中国科学院、江南大学和中国科学院大学;从WOS核心合集数据库来看多个国家对菊粉展开了研究,中国发文量最多(890篇),可见中国对菊粉研究作出了巨大贡献。不同作者和机构间虽有合作,但研究领域较为分散、合作还不够密切。CNKI数据库和WOS核心合集数据库关键词分析可以看出研究大多是以菊粉的益生元功效展开探索,并重视菊粉在食品领域的应用;突现词分析表明菊粉稳定性、协同作用、生物活性等是当下研究的热点。菊粉发展潜力巨大,在食品和医药领域的开发将成为未来研究的趋势,尤其是以菊粉为原料进行食品研发,同时将菊粉用于药物递送载体、药物稳定剂、疫苗佐剂等将成为未来研究的重点。整体而言,该研究为菊粉未来的研究与开发提供了数据支撑。
基金Supported by the National College Students’Innovative Entrepreneurial Training Plan Program,No.202410403067the Innovation and Entrepreneurship Training Program for College Students in Jiangxi Province,No.S202410403035.
文摘BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood swings.Effective drug treatment modalities are crucial for managing BD.AIM To analyze the current status and future trends of global research on BD drug treatment over the last decade.METHODS The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment.A total of 2624 articles were extracted.Data visualization and analysis were conducted using CiteSpace,VOSviewer,Pajek,Scimago Graphica,and R-studio bibliometrix to identify RESULTS The United States,China,and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration networks.The University of Pittsburgh,Massachusetts General Hospital,and the University of Michigan have been identified as the major research institutions in this field.The Journal of Affective Disorders is the most influential journal.A keyword analysis revealed research hotspots related to clinical symptoms,drug efficacy,and genetic mechanisms.A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited paper.CONCLUSION This study provides a detailed overview of the field of BD drug treatment,highlighting key contributors,research hotspots,and future directions.The study findings can be employed as a reference for future research and policymaking,which may enable further development and optimization of BD pharmacotherapy.
文摘BACKGROUND With the growing scholarly and clinical fascination with somatic symptom dis-order(SSD),a bibliometric analysis is lacking.AIM To conduct a bibliometric analysis to investigate the current status and frontiers of SSD.METHODS The documents related to SSD are obtained from the web of science core collection database(WoSCC),and VOSviewer 1.6.16 from January 1,2000 to December 31,2023,and the WoSCC’s literature analysis wire were used to conduct the biblio-metric analysis.RESULTS A total of 567 documents related to SSD were included,and 2325 authors across 947 institutions from 57 countries/regions have contributed to SSD research,published in 277 journals.The most productive author,institution,country and journal were Löwe B,University of Hamburg,Germany,and Journal of Psycho-somatic Research respectively.The first high-cited document was published in the Journal of Psychosomatic Research in 2013 by Dimsdale JE and colleagues,which explored the rationale behind the SSD diagnosis introduction in diagnostic and statistical manual of mental disorders.CONCLUSION In conclusion,the main research hotspots and frontiers in the field of SSD are validity and reliability of the SSD criteria,functional impairment of SSD,and the treatment for SSD.More high-quality studies are needed to assess the diagnosis and treatment of SSD.
