Background. We attempted to determine the prevalence of genital human papillomavirus (HPV) infection in women attending gynecologic practitioners in South Taiwan. Methods. The population included 4383 women aged 16- 7...Background. We attempted to determine the prevalence of genital human papillomavirus (HPV) infection in women attending gynecologic practitioners in South Taiwan. Methods. The population included 4383 women aged 16- 78 seeking HPV testing at primary gynecologic practitioners regardless of their cervical cytology results. HPV DNA was identified from cervical swabs using semi- nested polymerase chain reaction with MY11, MY09/HMB01, and MY11/bioGP6+ primers. Genotyping for high- risk HPV (HR- HPV) was done separately by a HR- HPV chip, which contained 13 type- specific oligonu- cleotides on a nylon membrane. Results. The overall HPV prevalence was 19.3% (849/4383), 11.1% (488/4383) were confirmed as HR- HPV positive. Among the women with HR- HPV infection, HPV- 16 was the most prevalent type (22.1% ; 108/488), followed by HPV- 52 (21.3% ; 104/488), and HPV- 58 (19.9% ; 97/488). Multiple infections were detected in 73 women (15.0% ; 73/488). For women with age 30 or younger, the overall HPV and HR- HPV prevalence were 32.0% and 20.7% , respectively, which were significantly higher than those of women age older than 30 (17.2% and 9.5% , P < 0.001). More multiple infections (22.1% vs. 12.4% ) were also found in women with age 30 or younger (P = 0.021). However, the relative contribution of types to the overall HR- HPV positive among different age groups remains the same. Conclusions. Our results showed an HPV prevalence that is similar compared with worldwide levels. HPV prevalence and multiple infections rate were decreasing across the age groups. Unlike most previous studies, the relative high prevalence of HPV 52 and 58 among South Taiwan women has important implications in vaccine prophylaxis.展开更多
目的从文献引证的角度透视《中华妇产科杂志》的学术水平和期刊质量。方法依据《中国生物医学期刊引文数据库》(Chinese Medical Citation Index,CMCI),采用文献计量方法对《中华妇产科杂志》载文被CMCI来源期刊引用的情况进行统计分析...目的从文献引证的角度透视《中华妇产科杂志》的学术水平和期刊质量。方法依据《中国生物医学期刊引文数据库》(Chinese Medical Citation Index,CMCI),采用文献计量方法对《中华妇产科杂志》载文被CMCI来源期刊引用的情况进行统计分析及评价。结果发文被引比例为55.21%,单篇论文平均被引次数为4.19次,被引作者群的地域分布30个省(直辖市)和国外,北京、广东和上海在妇产科研究领域居于前列。有559种期刊引用该刊,自引率为0.0512。结论《中华妇产科杂志》所载文献质量较高,形成具有独立风格和特色且相对稳定的研究体系。该刊不仅是我国妇产科研究领域最重要的信息源之一,也是我国医学领域的主要核心期刊。展开更多
文摘Background. We attempted to determine the prevalence of genital human papillomavirus (HPV) infection in women attending gynecologic practitioners in South Taiwan. Methods. The population included 4383 women aged 16- 78 seeking HPV testing at primary gynecologic practitioners regardless of their cervical cytology results. HPV DNA was identified from cervical swabs using semi- nested polymerase chain reaction with MY11, MY09/HMB01, and MY11/bioGP6+ primers. Genotyping for high- risk HPV (HR- HPV) was done separately by a HR- HPV chip, which contained 13 type- specific oligonu- cleotides on a nylon membrane. Results. The overall HPV prevalence was 19.3% (849/4383), 11.1% (488/4383) were confirmed as HR- HPV positive. Among the women with HR- HPV infection, HPV- 16 was the most prevalent type (22.1% ; 108/488), followed by HPV- 52 (21.3% ; 104/488), and HPV- 58 (19.9% ; 97/488). Multiple infections were detected in 73 women (15.0% ; 73/488). For women with age 30 or younger, the overall HPV and HR- HPV prevalence were 32.0% and 20.7% , respectively, which were significantly higher than those of women age older than 30 (17.2% and 9.5% , P < 0.001). More multiple infections (22.1% vs. 12.4% ) were also found in women with age 30 or younger (P = 0.021). However, the relative contribution of types to the overall HR- HPV positive among different age groups remains the same. Conclusions. Our results showed an HPV prevalence that is similar compared with worldwide levels. HPV prevalence and multiple infections rate were decreasing across the age groups. Unlike most previous studies, the relative high prevalence of HPV 52 and 58 among South Taiwan women has important implications in vaccine prophylaxis.
文摘目的从文献引证的角度透视《中华妇产科杂志》的学术水平和期刊质量。方法依据《中国生物医学期刊引文数据库》(Chinese Medical Citation Index,CMCI),采用文献计量方法对《中华妇产科杂志》载文被CMCI来源期刊引用的情况进行统计分析及评价。结果发文被引比例为55.21%,单篇论文平均被引次数为4.19次,被引作者群的地域分布30个省(直辖市)和国外,北京、广东和上海在妇产科研究领域居于前列。有559种期刊引用该刊,自引率为0.0512。结论《中华妇产科杂志》所载文献质量较高,形成具有独立风格和特色且相对稳定的研究体系。该刊不仅是我国妇产科研究领域最重要的信息源之一,也是我国医学领域的主要核心期刊。
