Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and heterogeneous.This review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western ...Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and heterogeneous.This review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western medical practices,emphasizing the development of nutraceuticals for cancer prevention.Using advanced analytical chemistry and food chemistry techniques,this study investigated how TCM components may be optimized for nutraceutical development.Focusing on molecular interactions with GC pathways,particularly the NF-κB,PI3K/Akt,and Wnt/β-catenin pathways,we examined the effects of TCM polyherbal formulas,extracts,and isolated compounds.These agents modulate apoptosis and cellular proliferation,underscoring their potential in preventive strategies.The convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health framework.This approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease prevention.The combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.展开更多
This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to ...This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to elucidate the mechanism of action of Yigong Sang,a traditional Chinese medicine(TCM),in the treatment of gastric cancer(GC).The mechanism of action of Yigong Sang in the treatment of GC has not yet been elucidated because it is composed of multiple Chinese medicines with multiple components and multiple targets.The emergence of network pharmacology and bioinformatics analysis helps explain the mechanism of action of TCM in preventing and treating GC,and provides a possibility for TCM to transform from empirical to evidence-based medicine.This is of great significance for the application of TCM in oncology,new drug development,formula optimization,and the improvement of clinical efficacy.展开更多
目的:评估美国国立综合癌症网(National Comprehensive Cancer Network,NCCN)推荐的心理痛苦温度计(Distress Thermometer,DT)在中国癌症患者中的使用情况,探索癌症患者显著心理痛苦的检出率并探讨影响心理痛苦的危险因素。方法:使用DT...目的:评估美国国立综合癌症网(National Comprehensive Cancer Network,NCCN)推荐的心理痛苦温度计(Distress Thermometer,DT)在中国癌症患者中的使用情况,探索癌症患者显著心理痛苦的检出率并探讨影响心理痛苦的危险因素。方法:使用DT,对北京肿瘤医院2007年9月-2008年1月间新入院治疗的4815例癌症患者进行心理痛苦筛查。通过描述性统计分析中国癌症患者显著心理痛苦(DT≥4分)的检出率及其产生的主要因素;根据医院统计部门提供的入组本次研究对象的部分人口社会学资料,分析年龄、性别、癌症类型、职业等对显著心理痛苦检出率的影响,Logistics回归分析探讨心理痛苦的预测因素。结果:DT筛查结果显示,我国癌症患者显著心理痛苦的总体检出率为24.2%;引起心理痛苦的主要原因有:担忧、疲乏、睡眠、疼痛、经济问题、记忆力/注意力下降、紧张、进食困难、恶心及手脚麻木等。由问题列表中的情绪问题引起的心理痛苦比例占总样本量的13.5%;多因素分析显示女性是出现显著心理痛苦的危险因素(OR=1.459)。结论:心理痛苦温度计适用于对我国门诊及住院的癌症患者进行心理痛苦筛查,及时发现患者心理痛苦的程度和原因;对其进行测量学上信度和效度的检验后可以在全国范围内推广使用。展开更多
文摘Gastric cancer(GC),the third leading cause of cancer-related death globally,is complex and heterogeneous.This review explores multidisciplinary investigations of traditional Chinese medicine(TCM)combined with Western medical practices,emphasizing the development of nutraceuticals for cancer prevention.Using advanced analytical chemistry and food chemistry techniques,this study investigated how TCM components may be optimized for nutraceutical development.Focusing on molecular interactions with GC pathways,particularly the NF-κB,PI3K/Akt,and Wnt/β-catenin pathways,we examined the effects of TCM polyherbal formulas,extracts,and isolated compounds.These agents modulate apoptosis and cellular proliferation,underscoring their potential in preventive strategies.The convergence of nutraceutical and medicine food homology studies highlights a significant shift towards integrating TCM-derived compounds in a preventive health framework.This approach aims not only to enhance efficacy and reduce side effects but also to champion a preventive paradigm using personalized medicine to advance proactive health maintenance and disease prevention.The combination of TCM and western medical practices offers promising avenues for future research and practical applications in GC prevention.
基金2023 Government-funded Project of the Outstanding Talents Training Program in Clinical Medicine,No.ZF2023165Key Research and Development Projects of Hebei Province,No.18277731D.
文摘This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to elucidate the mechanism of action of Yigong Sang,a traditional Chinese medicine(TCM),in the treatment of gastric cancer(GC).The mechanism of action of Yigong Sang in the treatment of GC has not yet been elucidated because it is composed of multiple Chinese medicines with multiple components and multiple targets.The emergence of network pharmacology and bioinformatics analysis helps explain the mechanism of action of TCM in preventing and treating GC,and provides a possibility for TCM to transform from empirical to evidence-based medicine.This is of great significance for the application of TCM in oncology,new drug development,formula optimization,and the improvement of clinical efficacy.
文摘目的:评估美国国立综合癌症网(National Comprehensive Cancer Network,NCCN)推荐的心理痛苦温度计(Distress Thermometer,DT)在中国癌症患者中的使用情况,探索癌症患者显著心理痛苦的检出率并探讨影响心理痛苦的危险因素。方法:使用DT,对北京肿瘤医院2007年9月-2008年1月间新入院治疗的4815例癌症患者进行心理痛苦筛查。通过描述性统计分析中国癌症患者显著心理痛苦(DT≥4分)的检出率及其产生的主要因素;根据医院统计部门提供的入组本次研究对象的部分人口社会学资料,分析年龄、性别、癌症类型、职业等对显著心理痛苦检出率的影响,Logistics回归分析探讨心理痛苦的预测因素。结果:DT筛查结果显示,我国癌症患者显著心理痛苦的总体检出率为24.2%;引起心理痛苦的主要原因有:担忧、疲乏、睡眠、疼痛、经济问题、记忆力/注意力下降、紧张、进食困难、恶心及手脚麻木等。由问题列表中的情绪问题引起的心理痛苦比例占总样本量的13.5%;多因素分析显示女性是出现显著心理痛苦的危险因素(OR=1.459)。结论:心理痛苦温度计适用于对我国门诊及住院的癌症患者进行心理痛苦筛查,及时发现患者心理痛苦的程度和原因;对其进行测量学上信度和效度的检验后可以在全国范围内推广使用。
