Objective To measure volume and other parameters of normal adrenal glands in Chinese adults with 64-slice multidetector CT, to evaluate the relationship of volume result with age, sex and body size, and to explore the...Objective To measure volume and other parameters of normal adrenal glands in Chinese adults with 64-slice multidetector CT, to evaluate the relationship of volume result with age, sex and body size, and to explore the correlations between adrenal volume and other measurements. Methods This study was based on 125 acquired contrast-enhanced upper abdominal CT scans performed with a 64-slice CT. The final study group consisted of 81 patients (49 males, 32 females). Portal venous phase images were studied for the measurements. Both the reconstruction interval and thickness were 1.5 mm. Each adrenal gland was outlined manually with computer-assistant technology to calculate its volume. The maximal sectional area, length, width and thickness of each adrenal gland were also measured. Results The mean age of total population was 47.9±13.0 (range: 20-76) years. The left, right, and total adrenal gland volumes were 4.23±0.74 (range: 2.85-5.83) cm 3 , 4.26±0.86 (2.59-6.56) cm 3 , and 8.50±1.40 (5.80-11.39) cm 3 , respectively. These volumes increased with weight (r=0.381, 0.389, and 0.437 respectively, all P<0.001), height (r=0.386, P<0.001; r=0.297, P=0.007; r=0.384, P<0.001) and body surface area (r=0.406, 0.392, and 0.452, all P<0.001). There was no significant difference in left, right or total adrenal volume with regard to sex after applying General Linear Model procedure to reduce the impact of weight (F=1.304, 0.064, and 0.597, all P>0.05), nor did volume change significantly with age (r=-0.033, -0.014, and -0.026, all P>0.05). Nearly all descriptors of bilateral adrenal glands correlated with ipsilateral volume except thickness (r=-0.027, P=0.814) and width (r=0.166, P=0.138) in the left side. Among these parameters, length had a stronger correlation with volume than others in the both left (r=0.412, P<0.001) and right (r=0.516, P<0.001) adrenal glands. Conclusion Our study has defined the volume distribution and other parameters of normal adrenal glands in Chinese adults, which provide a baseline for future studies.展开更多
AIM： To investigate and review the contrast-enhanced multiple-phase computed tomography （CEMP CT） and magnetic resonance imaging （MRI） findings in patients with pathologically confirmed hepatic epithelioid hemang...AIM： To investigate and review the contrast-enhanced multiple-phase computed tomography （CEMP CT） and magnetic resonance imaging （MRI） findings in patients with pathologically confirmed hepatic epithelioid hemangioendothelioma （HEHE）. METHODS： Findings from imaging examinations in 8 patients （5 women and 3 men） with pathologically confirmed HEHE were retrospectively reviewed （CT images obtained from 7 patients and MR images obtained from 6 patients）. The age of presentation varied from 27 years to 60 years （average age 39.8 years）. RESULTS： There were two types of HEHE： multifocal type （n = 7） and diffuse type （n = 1）. Tn the multifocal-type cases, there were 74 lesions on CT and 28 lesions on MRI with 7 lesions found with diffusion weighted imaging; 18 （24.3%） of 74 lesions on plain CT and 26 （92.9%） of 28 lesions on pre-contrast MRI showed the target sign. On CEMP CT, 28 （37.8%） of 74 lesions appeared with the target sign and a progressive-enhancement rim and 9 （12.2%） of 74 lesions displayed progressive enhancement, maintaining a state of persistent enhancement. On CEMP MRI, 27 （96.4%） of 28 lesions appeared with the target sign with a progressive-enhancement rim and 28 （100%） of 28 lesions displayed progressive-enhancement, maintaining a state of persistent enhancement. In the diffuse-type cases, an enlarged liver was observed with a large nodule appearing with persistent enhancement on CEMP CT and MRI. CONCLUSION： The most important imaging features of HEHE are the target sign and/or progressive en- hancement with persistent enhancement on CEMP CT and MRI. MRI is advantageous over CT in displaying these imaging features.展开更多
Multimodal imaging nanoprobes are urgently sought because they can integrate different imaging func- tion into individual nanoplatform and provide more comprehensive and accurate information for the diagnosis of early...Multimodal imaging nanoprobes are urgently sought because they can integrate different imaging func- tion into individual nanoplatform and provide more comprehensive and accurate information for the diagnosis of early-stage tumor. Lanthanide-based upconversion nanoparticles （UCNPs） are regarded as promising nanoplatforms to fabricate these probes. Herein, we firstly developed the active core-active shell structured NaYbF4：Tm@NaGdF4：Yb-PVP UCNPs with the average diameter of 13.23 ＋ 0.96 nm as multimodal imaging probes. These water-dispersible nanoprobes presented excellent near-infrared to near-infrared （NIR-to-NIR） upconversion luminescence （UCL） performance, which is favorable for optical bioimaging due to deeper tissue penetration and autofluorescence reduction. After coated with the NaGdF4：Yb active shell, the UCL emission intensity at 800 nm increased by 7.2 times. These nanoprobes exhibited a desirable longitudinal relaxivity （rl = 3.58 L/（mmol s）） and strong X-ray attenuation property （58.84 HU L/g）. The cytotoxicity assessment, histology analysis and biodistribution study revealed that NaYbF4：Tm@NaGdF4：Yb-PVP UCNPs had relatively low cytotoxicity and negligible organ toxicity. These UCNPs were applied for NIR-to-NIR UCL imaging in vivo. More importantly, the detection of small tumor was successfully achieved under Trweighted MRI and CT imaging modalities after intravenous injection of these UCNPs. These results revealed that NaYbF4：Tm@NaGdF4：Yb-PVP UCNPs could serve as promising NIR-to-NIR UCL/MRI/CT trimodal imaging probes.展开更多
文摘Objective To measure volume and other parameters of normal adrenal glands in Chinese adults with 64-slice multidetector CT, to evaluate the relationship of volume result with age, sex and body size, and to explore the correlations between adrenal volume and other measurements. Methods This study was based on 125 acquired contrast-enhanced upper abdominal CT scans performed with a 64-slice CT. The final study group consisted of 81 patients (49 males, 32 females). Portal venous phase images were studied for the measurements. Both the reconstruction interval and thickness were 1.5 mm. Each adrenal gland was outlined manually with computer-assistant technology to calculate its volume. The maximal sectional area, length, width and thickness of each adrenal gland were also measured. Results The mean age of total population was 47.9±13.0 (range: 20-76) years. The left, right, and total adrenal gland volumes were 4.23±0.74 (range: 2.85-5.83) cm 3 , 4.26±0.86 (2.59-6.56) cm 3 , and 8.50±1.40 (5.80-11.39) cm 3 , respectively. These volumes increased with weight (r=0.381, 0.389, and 0.437 respectively, all P<0.001), height (r=0.386, P<0.001; r=0.297, P=0.007; r=0.384, P<0.001) and body surface area (r=0.406, 0.392, and 0.452, all P<0.001). There was no significant difference in left, right or total adrenal volume with regard to sex after applying General Linear Model procedure to reduce the impact of weight (F=1.304, 0.064, and 0.597, all P>0.05), nor did volume change significantly with age (r=-0.033, -0.014, and -0.026, all P>0.05). Nearly all descriptors of bilateral adrenal glands correlated with ipsilateral volume except thickness (r=-0.027, P=0.814) and width (r=0.166, P=0.138) in the left side. Among these parameters, length had a stronger correlation with volume than others in the both left (r=0.412, P<0.001) and right (r=0.516, P<0.001) adrenal glands. Conclusion Our study has defined the volume distribution and other parameters of normal adrenal glands in Chinese adults, which provide a baseline for future studies.
文摘AIM： To investigate and review the contrast-enhanced multiple-phase computed tomography （CEMP CT） and magnetic resonance imaging （MRI） findings in patients with pathologically confirmed hepatic epithelioid hemangioendothelioma （HEHE）. METHODS： Findings from imaging examinations in 8 patients （5 women and 3 men） with pathologically confirmed HEHE were retrospectively reviewed （CT images obtained from 7 patients and MR images obtained from 6 patients）. The age of presentation varied from 27 years to 60 years （average age 39.8 years）. RESULTS： There were two types of HEHE： multifocal type （n = 7） and diffuse type （n = 1）. Tn the multifocal-type cases, there were 74 lesions on CT and 28 lesions on MRI with 7 lesions found with diffusion weighted imaging; 18 （24.3%） of 74 lesions on plain CT and 26 （92.9%） of 28 lesions on pre-contrast MRI showed the target sign. On CEMP CT, 28 （37.8%） of 74 lesions appeared with the target sign and a progressive-enhancement rim and 9 （12.2%） of 74 lesions displayed progressive enhancement, maintaining a state of persistent enhancement. On CEMP MRI, 27 （96.4%） of 28 lesions appeared with the target sign with a progressive-enhancement rim and 28 （100%） of 28 lesions displayed progressive-enhancement, maintaining a state of persistent enhancement. In the diffuse-type cases, an enlarged liver was observed with a large nodule appearing with persistent enhancement on CEMP CT and MRI. CONCLUSION： The most important imaging features of HEHE are the target sign and/or progressive en- hancement with persistent enhancement on CEMP CT and MRI. MRI is advantageous over CT in displaying these imaging features.
基金supported by the National Natural Science Foundation of China(21003013)the Jilin Province Science and Technology Development Project(No.20170101094JC)the Scientific Research Fund of Jilin Provincial Education Department (2016323)
文摘Multimodal imaging nanoprobes are urgently sought because they can integrate different imaging func- tion into individual nanoplatform and provide more comprehensive and accurate information for the diagnosis of early-stage tumor. Lanthanide-based upconversion nanoparticles （UCNPs） are regarded as promising nanoplatforms to fabricate these probes. Herein, we firstly developed the active core-active shell structured NaYbF4：Tm@NaGdF4：Yb-PVP UCNPs with the average diameter of 13.23 ＋ 0.96 nm as multimodal imaging probes. These water-dispersible nanoprobes presented excellent near-infrared to near-infrared （NIR-to-NIR） upconversion luminescence （UCL） performance, which is favorable for optical bioimaging due to deeper tissue penetration and autofluorescence reduction. After coated with the NaGdF4：Yb active shell, the UCL emission intensity at 800 nm increased by 7.2 times. These nanoprobes exhibited a desirable longitudinal relaxivity （rl = 3.58 L/（mmol s）） and strong X-ray attenuation property （58.84 HU L/g）. The cytotoxicity assessment, histology analysis and biodistribution study revealed that NaYbF4：Tm@NaGdF4：Yb-PVP UCNPs had relatively low cytotoxicity and negligible organ toxicity. These UCNPs were applied for NIR-to-NIR UCL imaging in vivo. More importantly, the detection of small tumor was successfully achieved under Trweighted MRI and CT imaging modalities after intravenous injection of these UCNPs. These results revealed that NaYbF4：Tm@NaGdF4：Yb-PVP UCNPs could serve as promising NIR-to-NIR UCL/MRI/CT trimodal imaging probes.
