世界卫生组织(World Health Organization,WHO)将不孕症定义为有规律性生活、未避孕至少1年未受孕的夫妇。常见的不孕症病因有男方因素、女性排卵因素、输卵管因素等,一些患者经过不孕症常规评估仍无法确定不孕病因的称为不明原因不孕症...世界卫生组织(World Health Organization,WHO)将不孕症定义为有规律性生活、未避孕至少1年未受孕的夫妇。常见的不孕症病因有男方因素、女性排卵因素、输卵管因素等,一些患者经过不孕症常规评估仍无法确定不孕病因的称为不明原因不孕症(unexplained infertility,UI)。这种有争议的诊断是在没有发现女性和男性生殖系统的异常时做出的,因此UI的诊断遵循不孕症的“标准”检查。展开更多
目的:探讨子宫动脉血流参数联合血小板聚集功能预测不明原因复发性流产(URSA)的价值。方法:将2021年9月至2023年8月本院收治的94例URSA患者作为URSA组,另外将同期在本院进行产检的110例正常妊娠孕妇作为对照组。URSA患者随访至妊娠28周...目的:探讨子宫动脉血流参数联合血小板聚集功能预测不明原因复发性流产(URSA)的价值。方法:将2021年9月至2023年8月本院收治的94例URSA患者作为URSA组,另外将同期在本院进行产检的110例正常妊娠孕妇作为对照组。URSA患者随访至妊娠28周,根据妊娠结局分为正常妊娠组(n = 25)和流产组(n = 69)。比较2组患者子宫动脉血流参数、血小板聚集率;采用受试者工作特性(ROC)曲线评估子宫动脉血流参数、血小板聚集率对URSA患者妊娠结局的预测价值;采用二分类Logistic逐步回归分析探讨URSA患者妊娠结局的影响因素。结果:在搏动指数(PI)、动脉血流阻力指数(RI)、收缩期/舒张期血流速度比值(S/D)、血小板聚集率指标方面,URSA组相较于对照组更高(P P P Objective: To explore the value of the combination of uterine artery flow parameters and platelet aggregation function in predicting unexplained recurrent abortion (URSA). Methods: 94 patients with URSA from September 2021 to August 2023 were selected as the URSA group, and 110 normal pregnant women who underwent prenatal examination were selected as the control group. The URSA patients were followed up until 28 weeks of gestation and divided into the normal pregnancy group (n = 25) and the abortion group (n = 69) according to the pregnancy outcome. The uterine artery blood flow parameters and platelet aggregation rate were compared between the two groups. The predictive value of the uterine artery flow parameters and platelet aggregation rate for the pregnancy outcomes of URSA patients was evaluated by ROC. Binary Logistic stepwise regression was employed to explore the influencing factors of the pregnancy outcomes of URSA patients. Results: The indexes of the pulse index (PI), the arterial flow resistance index (RI), the systolic/diastolic blood flow velocity ratio (S/D), and the platelet aggregation rate in the URSA group were higher than those in the control group (P P P < 0.05). The ROC curve demonstrated that the area under the curve (AUC) (95% CI) of the uterine artery flow parameters, the platelet aggregation rate, and their combined prediction of the pregnancy outcomes of URSA patients were 0.858 (0.807~0.910), 0.764 (0.753~0.816), and 0.903 (0.852~0.955), respectively. Conclusion: The level of the uterine artery blood flow parameters and the increase of the platelet aggregation rate are closely associated with the pregnancy outcome of URSA patients, and the combined value of the two is highly significant in predicting the pregnancy outcome of URSA patients.展开更多
文摘世界卫生组织(World Health Organization,WHO)将不孕症定义为有规律性生活、未避孕至少1年未受孕的夫妇。常见的不孕症病因有男方因素、女性排卵因素、输卵管因素等,一些患者经过不孕症常规评估仍无法确定不孕病因的称为不明原因不孕症(unexplained infertility,UI)。这种有争议的诊断是在没有发现女性和男性生殖系统的异常时做出的,因此UI的诊断遵循不孕症的“标准”检查。
文摘目的:探讨子宫动脉血流参数联合血小板聚集功能预测不明原因复发性流产(URSA)的价值。方法:将2021年9月至2023年8月本院收治的94例URSA患者作为URSA组,另外将同期在本院进行产检的110例正常妊娠孕妇作为对照组。URSA患者随访至妊娠28周,根据妊娠结局分为正常妊娠组(n = 25)和流产组(n = 69)。比较2组患者子宫动脉血流参数、血小板聚集率;采用受试者工作特性(ROC)曲线评估子宫动脉血流参数、血小板聚集率对URSA患者妊娠结局的预测价值;采用二分类Logistic逐步回归分析探讨URSA患者妊娠结局的影响因素。结果:在搏动指数(PI)、动脉血流阻力指数(RI)、收缩期/舒张期血流速度比值(S/D)、血小板聚集率指标方面,URSA组相较于对照组更高(P P P Objective: To explore the value of the combination of uterine artery flow parameters and platelet aggregation function in predicting unexplained recurrent abortion (URSA). Methods: 94 patients with URSA from September 2021 to August 2023 were selected as the URSA group, and 110 normal pregnant women who underwent prenatal examination were selected as the control group. The URSA patients were followed up until 28 weeks of gestation and divided into the normal pregnancy group (n = 25) and the abortion group (n = 69) according to the pregnancy outcome. The uterine artery blood flow parameters and platelet aggregation rate were compared between the two groups. The predictive value of the uterine artery flow parameters and platelet aggregation rate for the pregnancy outcomes of URSA patients was evaluated by ROC. Binary Logistic stepwise regression was employed to explore the influencing factors of the pregnancy outcomes of URSA patients. Results: The indexes of the pulse index (PI), the arterial flow resistance index (RI), the systolic/diastolic blood flow velocity ratio (S/D), and the platelet aggregation rate in the URSA group were higher than those in the control group (P P P < 0.05). The ROC curve demonstrated that the area under the curve (AUC) (95% CI) of the uterine artery flow parameters, the platelet aggregation rate, and their combined prediction of the pregnancy outcomes of URSA patients were 0.858 (0.807~0.910), 0.764 (0.753~0.816), and 0.903 (0.852~0.955), respectively. Conclusion: The level of the uterine artery blood flow parameters and the increase of the platelet aggregation rate are closely associated with the pregnancy outcome of URSA patients, and the combined value of the two is highly significant in predicting the pregnancy outcome of URSA patients.
