Determination of the optimal model parameters for biochemical systems is a time consuming iterative process. In this study, a novel hybrid differential evolution (DE) algorithm based on the differential evolution te...Determination of the optimal model parameters for biochemical systems is a time consuming iterative process. In this study, a novel hybrid differential evolution (DE) algorithm based on the differential evolution technique and a local search strategy is developed for solving kinetic parameter estimation problems. By combining the merits of DE with Gauss-Newton method, the proposed hybrid approach employs a DE algorithm for identifying promising regions of the solution space followed by use of Gauss-Newton method to determine the optimum in the identified regions. Some well-known benchmark estimation problems are utilized to test the efficiency and the robustness of the proposed algorithm compared to other methods in literature. The comparison indicates that the present hybrid algorithm outperforms other estimation techniques in terms of the global searching ability and the con- vergence speed. Additionally, the estimation of kinetic model parameters for a feed batch fermentor is carried out to test the applicability of the proposed algorithm. The result suggests that the method can be used to estimate suitable values of model oarameters for a comolex mathematical model.展开更多
The authors study the asymptotic behavior of the smooth solutions to the Cauchy problems for two macroscopic models (hydrodynamic and drift-diffusion models) for semiconductors and the related relaxation limit problem...The authors study the asymptotic behavior of the smooth solutions to the Cauchy problems for two macroscopic models (hydrodynamic and drift-diffusion models) for semiconductors and the related relaxation limit problem. First, it is proved that the solutions to these two systems converge to the unique stationary solution time asymptotically without the smallness assump- tion on doping profile. Then, very sharp estimates on the smooth solutions, independent of the relaxation time, are obtained and used to establish the zero relaxation limit.展开更多
In this paper, an HIV-1 infection model with absorption, saturation infection and an intracellular delay accounting for the time between viral entry into a target cell and the production of new virus particles is inve...In this paper, an HIV-1 infection model with absorption, saturation infection and an intracellular delay accounting for the time between viral entry into a target cell and the production of new virus particles is investigated. By analyzing the characteristic equations, the local stability of an infection-free equilibrium and a chronic-infection equilibrium of the model is established. By using suitable Lyapunov functionals and LaSalle's invariance principle, it is proved that if the basic reproduction ratio is less than unity, the infection-free equilibrium is globally asymptotically stable; and if the basic reproduction ratio is greater than unity, sufficient condition is derived for the global stability of the chronic-infection equilibrium.展开更多
We study the global dynamics of a nonlocal population model with age structure in a bounded domain. We mainly concern with the case where the birth rate decreases as the mature population size become large. The analys...We study the global dynamics of a nonlocal population model with age structure in a bounded domain. We mainly concern with the case where the birth rate decreases as the mature population size become large. The analysis is rather subtle and it is inadequate to apply the powerful theory of monotone dynamical systems. By using the method of super-sub solutions, combined with the careful analysis of the kernel function in the nonlocal term, we prove nonexistence, existence and uniqueness of positive steady states of the model.Moreover, due to the mature individuals do not diffuse, the solution semiflow to the model is not compact. To overcome the difficulty of non-compactness in describing the global asymptotic stability of the unique positive steady state, we first establish an appropriate comparison principle. With the help of the comparison principle,we can employ the theory of dissipative systems to obtain the global asymptotic stability of the unique positive steady state. The main results are illustrated with the nonlocal Nicholson's blowflies equation and the nonlocal Mackey-Glass equation.展开更多
In this paper, the global properties of a mathematical modeling of hepatitis C virus (HCV) with distributed time delays is studied. Lyapunov functionals are constructed to establish the global asymptotic stability o...In this paper, the global properties of a mathematical modeling of hepatitis C virus (HCV) with distributed time delays is studied. Lyapunov functionals are constructed to establish the global asymptotic stability of the uninfected and infected steady states. It is shown that if the basic reproduction number R0 is less than unity, then the uninfected steady state is globally asymptotically stable. If the basic reproduction number R0 is larger than unity, then the infected steady state is globally asymptotically stable.展开更多
In this paper, based on a class of multi-group epidemic models of SEIR type with bilinear incidences, we introduce a vaccination compartment, leading to multi-group SVEIR model. We establish that the global dynamics a...In this paper, based on a class of multi-group epidemic models of SEIR type with bilinear incidences, we introduce a vaccination compartment, leading to multi-group SVEIR model. We establish that the global dynamics are completely determined by the basic reproduction number R0V which is defined by the spectral radius of the next generation matrix. Our proofs of global stability of the equilibria utilize a graph-theoretical approach to the method of Lyapunov functionals. Mathematical results suggest that vaccination is helpful for disease control by decreasing the basic reproduction number. However, there is a necessary condition for successful elimination of disease. If the time for the vaccines to obtain immunity or the possibility for them to be infected before acquiring immunity is neglected in each group, this condition will be satisfied and the disease can always be eradicated by suitable vaccination strategies. This may lead to over evaluation for the effect of vaccination.展开更多
The global dynamics of a cholera model with delay is considered. We determine a basic reproduction number R0 which is chosen based on the relative ODE model, and establish that the global dynamics are determined by th...The global dynamics of a cholera model with delay is considered. We determine a basic reproduction number R0 which is chosen based on the relative ODE model, and establish that the global dynamics are determined by the threshold value R0. If R0 〈 1, then the infection-free equilibrium is global asymptotically stable, that is, the cholera dies out; If R0 〉 1, then the unique endemic equilibrium is global asymptotically stable, which means that the infection persists. The results obtained show that the delay does not lead to periodic oscillations. Finally, some numerical simulations support our theoretical results.展开更多
In this work, in order to identify the most effective measure and combinations of several measures to control influenza spread, we propose an SVEIAR influenza model with imperfect vaccination, media coverage and antiv...In this work, in order to identify the most effective measure and combinations of several measures to control influenza spread, we propose an SVEIAR influenza model with imperfect vaccination, media coverage and antiviral treatment. The global dynamics of the model is explored. Sensitivity analysis of the basic reproduction number and the endemic equilibrium is conducted to evaluate the effectiveness of influenza control measures. Purthermore, an optimal control problem incorporating the three measures is formulated to design optimal control strategies for influenza. The cost-effectiveness analysis reveals that combining the three measures is the most cost-effective among the strategies considered. Numerical simulations show that media propaganda can play a dominant role in curbing influenza transmission.展开更多
In this paper, we study the global dynamics of a SVEIS epidemic model with distinct incidence for exposed and infectives. The model is analyzed for stability and bifurcation behavior. To account for the realistic phen...In this paper, we study the global dynamics of a SVEIS epidemic model with distinct incidence for exposed and infectives. The model is analyzed for stability and bifurcation behavior. To account for the realistic phenomenon of non-homogeneous mixing, the effect of diffusion on different population subclasses is considered. The diffusive model is analyzed using matrix stability theory and conditions for Turing bifurcation are derived. Numerical simulations support our analytical results on the dynamic behavior of tile model.展开更多
基金Supported by the National Natural Science Foundation of China (60804027, 61064003) and Fuzhou University Research Foundation (FZU-02335, 600338 and 600567).
文摘Determination of the optimal model parameters for biochemical systems is a time consuming iterative process. In this study, a novel hybrid differential evolution (DE) algorithm based on the differential evolution technique and a local search strategy is developed for solving kinetic parameter estimation problems. By combining the merits of DE with Gauss-Newton method, the proposed hybrid approach employs a DE algorithm for identifying promising regions of the solution space followed by use of Gauss-Newton method to determine the optimum in the identified regions. Some well-known benchmark estimation problems are utilized to test the efficiency and the robustness of the proposed algorithm compared to other methods in literature. The comparison indicates that the present hybrid algorithm outperforms other estimation techniques in terms of the global searching ability and the con- vergence speed. Additionally, the estimation of kinetic model parameters for a feed batch fermentor is carried out to test the applicability of the proposed algorithm. The result suggests that the method can be used to estimate suitable values of model oarameters for a comolex mathematical model.
基金Project supported by the National Natural Science Foundation of China, the Grant of MST of China,the National Natural Science
文摘The authors study the asymptotic behavior of the smooth solutions to the Cauchy problems for two macroscopic models (hydrodynamic and drift-diffusion models) for semiconductors and the related relaxation limit problem. First, it is proved that the solutions to these two systems converge to the unique stationary solution time asymptotically without the smallness assump- tion on doping profile. Then, very sharp estimates on the smooth solutions, independent of the relaxation time, are obtained and used to establish the zero relaxation limit.
文摘In this paper, an HIV-1 infection model with absorption, saturation infection and an intracellular delay accounting for the time between viral entry into a target cell and the production of new virus particles is investigated. By analyzing the characteristic equations, the local stability of an infection-free equilibrium and a chronic-infection equilibrium of the model is established. By using suitable Lyapunov functionals and LaSalle's invariance principle, it is proved that if the basic reproduction ratio is less than unity, the infection-free equilibrium is globally asymptotically stable; and if the basic reproduction ratio is greater than unity, sufficient condition is derived for the global stability of the chronic-infection equilibrium.
基金supported by National Natural Science Foundation of China(Grant Nos.11031002 and 11371107)the Research Fund for the Doctoral Program of Higher Education of China(Grant No.20124410110001)
文摘We study the global dynamics of a nonlocal population model with age structure in a bounded domain. We mainly concern with the case where the birth rate decreases as the mature population size become large. The analysis is rather subtle and it is inadequate to apply the powerful theory of monotone dynamical systems. By using the method of super-sub solutions, combined with the careful analysis of the kernel function in the nonlocal term, we prove nonexistence, existence and uniqueness of positive steady states of the model.Moreover, due to the mature individuals do not diffuse, the solution semiflow to the model is not compact. To overcome the difficulty of non-compactness in describing the global asymptotic stability of the unique positive steady state, we first establish an appropriate comparison principle. With the help of the comparison principle,we can employ the theory of dissipative systems to obtain the global asymptotic stability of the unique positive steady state. The main results are illustrated with the nonlocal Nicholson's blowflies equation and the nonlocal Mackey-Glass equation.
文摘In this paper, the global properties of a mathematical modeling of hepatitis C virus (HCV) with distributed time delays is studied. Lyapunov functionals are constructed to establish the global asymptotic stability of the uninfected and infected steady states. It is shown that if the basic reproduction number R0 is less than unity, then the uninfected steady state is globally asymptotically stable. If the basic reproduction number R0 is larger than unity, then the infected steady state is globally asymptotically stable.
文摘In this paper, based on a class of multi-group epidemic models of SEIR type with bilinear incidences, we introduce a vaccination compartment, leading to multi-group SVEIR model. We establish that the global dynamics are completely determined by the basic reproduction number R0V which is defined by the spectral radius of the next generation matrix. Our proofs of global stability of the equilibria utilize a graph-theoretical approach to the method of Lyapunov functionals. Mathematical results suggest that vaccination is helpful for disease control by decreasing the basic reproduction number. However, there is a necessary condition for successful elimination of disease. If the time for the vaccines to obtain immunity or the possibility for them to be infected before acquiring immunity is neglected in each group, this condition will be satisfied and the disease can always be eradicated by suitable vaccination strategies. This may lead to over evaluation for the effect of vaccination.
文摘The global dynamics of a cholera model with delay is considered. We determine a basic reproduction number R0 which is chosen based on the relative ODE model, and establish that the global dynamics are determined by the threshold value R0. If R0 〈 1, then the infection-free equilibrium is global asymptotically stable, that is, the cholera dies out; If R0 〉 1, then the unique endemic equilibrium is global asymptotically stable, which means that the infection persists. The results obtained show that the delay does not lead to periodic oscillations. Finally, some numerical simulations support our theoretical results.
基金Acknowledgments The work was supported by National Natural Science Foundation of China (Nos. 11261017, 11371161), and the key scientific research project of Education Department of Hubei Province of China (No. D20101902).
文摘In this work, in order to identify the most effective measure and combinations of several measures to control influenza spread, we propose an SVEIAR influenza model with imperfect vaccination, media coverage and antiviral treatment. The global dynamics of the model is explored. Sensitivity analysis of the basic reproduction number and the endemic equilibrium is conducted to evaluate the effectiveness of influenza control measures. Purthermore, an optimal control problem incorporating the three measures is formulated to design optimal control strategies for influenza. The cost-effectiveness analysis reveals that combining the three measures is the most cost-effective among the strategies considered. Numerical simulations show that media propaganda can play a dominant role in curbing influenza transmission.
文摘In this paper, we study the global dynamics of a SVEIS epidemic model with distinct incidence for exposed and infectives. The model is analyzed for stability and bifurcation behavior. To account for the realistic phenomenon of non-homogeneous mixing, the effect of diffusion on different population subclasses is considered. The diffusive model is analyzed using matrix stability theory and conditions for Turing bifurcation are derived. Numerical simulations support our analytical results on the dynamic behavior of tile model.