Oral and maxillofacial malignancies still remain significant health problems worldwide, the 5- year relativesurvival rate was 47.7% for oral squamous cell carcinoma and 64.7% for carcinomas of the major salivary gland...Oral and maxillofacial malignancies still remain significant health problems worldwide, the 5- year relativesurvival rate was 47.7% for oral squamous cell carcinoma and 64.7% for carcinomas of the major salivary glands accordingto NCDB reports. Successful management of these malignancies now requires a cooperative or multidisciplinary approachstrongly evidence based, ordered, even individualized rather than randomized, among a broad group of medical disciplinesincluding head and neck surgery, radiation oncology, medical oncology, medical imaging, clinical pathology and labmedicine, social work, nutrition, and others. Different treatment modalities are mandatory for different primary sites,histopathologic types, different TNM stages and different patients, either dominated by surgery, radiation therapy orchemotherapy, coordinated other modalities. This paper evaluated and summarized current comprehensive and sequentialapproaches to the management of oral and maxillofacial malignancies, emphasizing the importance of multidisciplinaryteam approach to coordinate surgery, radiation therapy and chemotherapy. The roles of induction chemotherapy andconcomitant chemoradiotherapy were also discussed. Comprehensive strategies for different oral and maxillofacialmalignancies had been proposed by National Comprehensive Cancer Network (NCCN) and introduced to the Chinesecolleagues for clinical references. The future lies in the development of individualized treatment regimes that combineearly detection with organ preservation and result in improved cure rates and quality of life, study of the best treatmentorder of the three disciplines of surgery, radiation, and chemotherapy; the refinement of radiation by altering fraction dose,sequence, and time course; radiosensitization by chemo- and biologic therapy; and the addition of novel, biologicallytargeted agents to these disciplines.展开更多
头颈肿瘤学形成只有半个多世纪的历史，经过两代医师的努力和探索研究，临床疗效不断提高，但由于头颈肿瘤患者不多，人们（医师和患者同样）对头颈肿瘤学的认识深度不足，存在的问题还不少。头颈部肿瘤发病率不高。美国SEER（Sunreilla...头颈肿瘤学形成只有半个多世纪的历史，经过两代医师的努力和探索研究，临床疗效不断提高，但由于头颈肿瘤患者不多，人们（医师和患者同样）对头颈肿瘤学的认识深度不足，存在的问题还不少。头颈部肿瘤发病率不高。美国SEER（Sunreillance，Epi（{emiologv and End Results，）统计17地区资料，2003—2007年，全身恶性肿瘤年发病率461．6／10万，其中头颈部26．1。展开更多
文摘Oral and maxillofacial malignancies still remain significant health problems worldwide, the 5- year relativesurvival rate was 47.7% for oral squamous cell carcinoma and 64.7% for carcinomas of the major salivary glands accordingto NCDB reports. Successful management of these malignancies now requires a cooperative or multidisciplinary approachstrongly evidence based, ordered, even individualized rather than randomized, among a broad group of medical disciplinesincluding head and neck surgery, radiation oncology, medical oncology, medical imaging, clinical pathology and labmedicine, social work, nutrition, and others. Different treatment modalities are mandatory for different primary sites,histopathologic types, different TNM stages and different patients, either dominated by surgery, radiation therapy orchemotherapy, coordinated other modalities. This paper evaluated and summarized current comprehensive and sequentialapproaches to the management of oral and maxillofacial malignancies, emphasizing the importance of multidisciplinaryteam approach to coordinate surgery, radiation therapy and chemotherapy. The roles of induction chemotherapy andconcomitant chemoradiotherapy were also discussed. Comprehensive strategies for different oral and maxillofacialmalignancies had been proposed by National Comprehensive Cancer Network (NCCN) and introduced to the Chinesecolleagues for clinical references. The future lies in the development of individualized treatment regimes that combineearly detection with organ preservation and result in improved cure rates and quality of life, study of the best treatmentorder of the three disciplines of surgery, radiation, and chemotherapy; the refinement of radiation by altering fraction dose,sequence, and time course; radiosensitization by chemo- and biologic therapy; and the addition of novel, biologicallytargeted agents to these disciplines.
文摘头颈肿瘤学形成只有半个多世纪的历史，经过两代医师的努力和探索研究，临床疗效不断提高，但由于头颈肿瘤患者不多，人们（医师和患者同样）对头颈肿瘤学的认识深度不足，存在的问题还不少。头颈部肿瘤发病率不高。美国SEER（Sunreillance，Epi（{emiologv and End Results，）统计17地区资料，2003—2007年，全身恶性肿瘤年发病率461．6／10万，其中头颈部26．1。
