Load-bearing characteristics and energy evolution of fractured rock masses after granite and sandstone grouting

Experiments on grouting-reinforced rock mass specimens with different particle sizes and features were carried out in this study to examine the effects of grouting reinforcement on the load-bearing characteristics of fractured rock mass.The strength and deformation features of grouting-reinforced rock mass were analyzed under different loading manners;the energy evolution mechanism of grouting-reinforced rock mass specimens with different particle sizes and features was investigated;the energy dissipation ratio and post-peak stress decreasing rate were employed to evaluate the bearing stability of grouting-reinforced rock mass.The results show that the strength and ductility of granite-reinforced rock mass(GRM)under biaxial loading are higher than that of sandstone-reinforced rock mass(SRM)under uniaxial loading.Besides,the energy evolution characteristics of grouting-reinforced rock mass under uniaxial and biaxial loading mainly could be divided into early,middle,and late stages.In the early stage,total,elastic,and dissipation energies were quite small with flatter curves;in the middle stage,elastic energy increased rapidly,whereas dissipation energy increased slowly;in the late stage,dissipation energy increased sharply.The energy dissipation ratio was used to represent the pre-peak plastic deformation.Under uniaxial loading,this ratio increased as the particle size increased and the pre-peak plastic deformation of grouting-reinforced rock mass became larger;under biaxial loading,it dropped as the particle size increased,and the pre-peak plastic deformation of grouting-reinforced rock mass became smaller.The post-peak stress decline rate A_(v) was used to assess the post-peak bearing performance of grouting-reinforced rock mass.Under uniaxial loading,parameter A_(v) exhibited reduction as the particle size kept increasing,and the ability of post-peak of grouting-reinforced rock mass to allow deformation development was greater,and the bearing capacity was greater;under biaxial loading,A_(v) increased with the particle size,and the ability of post-peak of grouting-reinforced rock mass to allow deformation development was low and the bearing capacity was reduced.The findings are considered instrumental in improving the stability of the roadway-surrounding rock by granite and sandstone grouting.

蒋太后与大礼议

在明朝嘉靖年间的"大礼议"中,世宗之母蒋氏的尊崇问题始终是十分重要的。这体现在四个方面:蒋氏"尊称"问题是明世宗启动"大礼议"最为迫切和重要的原因;蒋氏入京礼仪之争,使明世宗初次突破"护礼派"的防线,争得了主动;在蒋、张太后"寿旦朝贺之争"中,世宗严惩护礼官员,实现了蒋氏"尊称"中加"皇"字的愿望;世宗强行去掉蒋氏"尊称"中的"本生"二字,导致左顺门事件的发生和"大礼议"的决定性胜利。蒋氏"尊称"问题的解决与否,直接影响着"大礼议"的进程。

Developmental Effects of Intraperitoneal Injection of Polychlorinated Biphenyls in Rats During Pregnancy

Polychlorinated biphenyls (PCBs) are widespread environmental contaminants that are possible health hazards for human beings through a variety of pathways.In the present study,50 time mated pregnant rats were divided into five groups and injected daily from gestational days 7 to 18 with either 2,2′,4,4′- tetrachlorobiphenyl (PCB 47) or 3,3′,4,4′- tetrachlorobiphenyl (PCB 77) or seseme oil (control) to evaluate the effects of these PCBs on prenatal and postnatal development.Offspring were examined for malformations of genitalia at birth and in adulthood.Body weight gains of these animals were checked every 7 days through postnatal day (PND) 119.There were no clinical signs of toxicity in the PCB-treated dams or their offspring throughout the experiment.Litter size and sex ratio of the litters were not affected.Both PCBs produced a significant increase in the females' anogenital distance,suggesting a modification of androgen responsiveness in females resulting from PCB exposure during development.Similar effects were not seen with the males.The proportion of individuals with eyes open by PND 15 was significantly reduced by both PCBs.Exposure to 1 mg/kg body weight of PCB 77 significantly reduced body weight gains in male pups from PND 35 to 119.However,no significant differences were found in body weight gains of the pups exposed to PCB 47.

Syllabus in the Light of Keeping Pace with the Times

Drawing up of syllabus plays a very important role in directing college English teaching. With the fast developing pace of the situation and the increasing requirements for undergraduates＇ English level, the available Syllabus is obviously far from satisfaction. This paper, from six perspectives, expounds the inadequacies and drawbacks of the Syllabus. It points out that college English teaching and the Syllabus need reform and should keep pace with the times.

Comparison of Soleus Muscle Fibers in Rats and Rabbits at Different Stages of Postnatal Development

In the present study,the effects of postnatal development on the number and distribution of skeletal muscle fibers of different types in hind leg of rat and rabbit were studied.The soleus muscles of rats aged 2 days,2,4,6,8,and 10 weeks (body weight 10,32,95,190,280,and 320 g),and rabbits aged 2 days,2,4,8,12,16,20,and 24 weeks (body weight 100,220,400,750,1 200,1 600,2 100,and 2 500 g) were stained with succinic dehydrogenase.With an image analysis system,the X-Y coordinates of fibers were used to analyze the growth-related changes.The results of present study showed that three types of fibers were found in the soleus muscles of rat and rabbit,i.e.,type Ⅰ (slow oxidative),ⅡX (fast oxidative),and ⅡA (fast oxidative glycolytic).The type Ⅰ fibers were present throughout the muscle that had a uniform distribution and tended to increase in number with aging.Type ⅡX fibers were scattered throughout the muscle and decreased markedly in number with aging.Type ⅡA fibers were located at the central and deep regions,and showed a little or no change in number and distribution with aging.While be of age,type ⅡA and ⅡX fibers became restricted to the superficial region.No type ⅡB fibers were detected.Type ⅡA fibers had the largest diameter,type Ⅰ intermediate and type ⅡX the smallest.Mean cross-sectional area of each type fibers of rabbits was larger than that of rats.The present results indicate that the number and distribution of muscle fibers of different types in hind limb of rat and rabbit change with the process of postnatal growth.

Follow-up Education of College English --An Analysis from Teacher＇s Perspective

The importance of follow-up education of college English has been obvious in recent years, but there are still many problems which need to be solved as soon as possible, such as how to carry out the follow-up education effectively and in what way to conduct the follow-up education and the course arrangement. The thesis hopes to solve the above problems to some extent.

Hybrid ToA and IMU indoor localization system by various algorithms

In this paper, we integrate inertial navigation system (INS) with wireless sensor network (WSN) to enhance the accuracy of indoor localization. Inertial measurement unit (IMU), the core of the INS, measures the accelerated and angular rotated speed of moving objects. Meanwhile, the ranges from the object to beacons, which are sensor nodes with known coordinates, are collected by time of arrival (ToA) approach. These messages are simultaneously collected and transmitted to the terminal. At the terminal, we set up the state transition models and observation models. According to them, several recursive Bayesian algorithms are applied to producing position estimations. As shown in the experiments, all of three algorithms do not require constant moving speed and perform better than standalone ToA system or standalone IMU system. And within them, two algorithms can be applied for the tracking on any path which is not restricted by the requirement that the trajectory between the positions at two consecutive time steps is a straight line.

Peritoneal carcinomatosis of colorectal origin:Incidence,prognosis and treatment options

Peritoneal carcinomatosis (PC) is one manifestation of metastatic colorectal cancer (CRC). Tumor growth on intestinal surfaces and associated fluid accumulation eventually result in bowel obstruction and incapacitating levels of ascites, which profoundly affect the quality of life for affected patients. PC appears resistant to traditional 5-fluorouracil-based chemotherapy, and surgery was formerly reserved for palliative purposes only. In the absence of effective treatment, the histori-cal prognosis for these patients was extremely poor, with an invariably fatal outcome. These poor outcomes likely explain why PC secondary to CRC has received little attention from oncologic researchers. Thus, data are lacking regarding incidence, clinical disease course, and accurate treatment evaluation for patients with PC. Recently, population-based studies have revealed that PC occurs relatively frequently among patients withCRC. Risk factors for developing PC have been identi-fied:right-sided tumor, advanced T-stage, advanced N-stage, poor differentiation grade, and younger age at diagnosis. During the past decade, both chemother-apeutical and surgical treatments have achieved prom-ising results in these patients. A chance for long-term survival or even cure may now be offered to selected patients by combining radical surgical resection with intraperitoneal instillation of heated chemotherapy. This combined procedure has become known as hy-perthermic intraperitoneal chemotherapy. This edito-rial outlines recent advancements in the medical and surgical treatment of PC and reviews the most recent information on incidence and prognosis of this disease. Given recent progress, treatment should now be considered in every patient presenting with PC.

SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer

AIM: To investigate the expression of markers that are correlated with the prognosis of colorectal cancer (CRC) patients. METHODS: One hundred and fifty-six CRC patientswere followed up for more than 3 years after radical surgery. Immunohistochemical (IHC) analysis was performed to detect the expression of 14 pathway-related markers (p53, APC, p21ras, E-cadherin, endothelin-B receptor, Shp2, ADCY-2, SPARCL1, neuroligin1, hsp27, mmp-9, MAPK, MSH2 and rho) in specimens from these patients. Bioinformatics analysis involving a Support Vector Machine (SVM) was used to determine the best prognostic model from combinations of these markers. RESULTS: Seven markers (SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK) were significantly related to the prognosis and clinical pathological features of the CRC patients (P < 0.05). Prognostic models were established through SVM from combinations of these 7 markers and proved able to differentiate patients with dissimilar survival, especially in stage Ⅱ/Ⅲ patients. According to the best prognostic model, the p53/SPARCL1 model, patients having high p53 and low SPARCL1 expression had about 50% lower 3-year survival than others (P < 0.001). CONCLUSION: SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in CRC. A p53/SPARCL1 bioinformatics model may be used as a supplement to tumor-nodes-metastasis staging.

S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer

AIM:To develop lymph node metastasis(LNM)-associated biomarkers for colorectal cancer(CRC) using quantitative proteome analysis.METHODS:Differences in protein expression between primary CRC with LNM(LNM CRC) and without LNM(non-LNM CRC) were assessed using methyl esterification stable isotope labeling coupled with 2D liquid chromatography followed by tandem mass spectrometry(2D-LC-MS/MS).The relationship to clinicopathological parameters and prognosis of candidate biomarkers was examined using an independent sample set.RESULTS:Forty-three proteins were found to be differentially expressed by at least 2.5-fold in two types of CRC.S100A4 was significantly upregulated in LNM CRC compared with non-LNM CRC,which was confirmed by Western blotting,immunohistochemistry and real-time quantitative polymerase chain reaction.Further immunohistochemistry on another 112 CRC cases showed that overexpression of S100A4 frequently existed in LNM CRC compared with non-LNM CRC(P < 0.001).Overexpression of S100A4 was significantly associated with LNM(P < 0.001),advanced TNM stage(P < 0.001),increased 5-year recurrence rate(P < 0.001) and decreased 5-year overall survival rate(P < 0.001).Univariate and multivariate analyses indicated that S100A4 expression was an independent prognostic factor for recurrence and survival of CRC patients(P < 0.05).CONCLUSION:S100A4 might serve as a powerful biomarker for LNM and a prognostic factor in CRC.

MAP based blocking artifact reduction for DCT domain distributed video coding

This paper proposes a maximum a posteriori （MAP） based blocking artifact reduction algorithm for discrete cosine transform （DCT） domain distributed video coding, in which the SI and the initial reconstructed Wyner-Ziv （WZ） frame are utilized to further estimate the original WZ frame. Though the MAP estimate improves quality of the artifact region, it also leads to over-smoothness and decreases quality of the non-artifact region. To overcome this problem, a criterion is presented to discriminate the artifact and the non-artifact region in the initial reconstructed WZ frame, and only the artifact region is updated with the MAP estimate. Simulation results show that the proposed algorithm provides obvious improvement in terms of both objective and subjective evaluations.

Benign retroperitoneal schwannoma presenting as colitis:A case report

We report a case of a patient presenting with clinical,radiological and endoscopic features of colitis due to a compressive left para-aortic mass. Total open surgical excision was performed,which resulted in complete resolution of colitis. Histopathology and immunohistochemistry revealed benign retroperitoneal schwannoma. These neural sheath tumors rarely occur in the retroperitoneum. They are usually asymptomatic but as they enlarge they may compress adjacent structures,which leads to a wide spectrum of non-specific symptoms,including lumbar pain,headache,secondary hypertension,abdominal pain and renal colicky pain. CT and MR findings show characteristic features,but none are specific. Schwannoma can be isolated sporadic lesions,or associated with schwannomatosis or neurofibromatosis type Ⅱ (NF2). Although they vary in biological and clinical behavior,their presence is,in nearly every case,due to alterations or absence of the NF2 gene,which is involved in the growth regulation of Schwann cells. Both conditions were excluded by thorough mutation analysis. Diagnosis is based on histopathological examination and immunohistochemistry. Total excision is therapeutic and has a good prognosis. Schwannomatosis and NF2 should be excluded through clinical diagnostic criteria. Genetic testing of NF2 is probably not justified in the presence of a solitary retroperitoneal schwannoma.

Research and application of schemes for constructing concrete pillars in large section finishing cut in backfill coal mining

Based on the technology of controlling surrounding rock deformation by constructing concrete pillars in large section finishing cut in backfill coal mining, the characteristics of vertical stress on concrete pillars and main factors influencing pillar stability are analyzed. By building a Winkler elastic foundation mechanical model for the support system constituted of coal pillar, backfill body and concrete pillars, mechanical calculation on stability of concrete pillar is carried out to evaluate the pillar stability and safety. Seven numeral models in three schemes with different pillar sizes, inter-row distances and compression ratios at the stopes were analyzed through numerical simulation according to width reduction principle. The practice of finishing cut at IIIB44 workface at Yangzhuang coal mine shows that： when the actual compression ratio is 86.5%, construction size inside the finishing cut is 2000 mm x 2000 mm and the interval between concrete pillars is 2000 mm x 2000 mm, the pillars can be stable with the maximum movement of two sides of each pillar being only 83 mm and 54 mm, which achieves the expected effect.

Changes in Post-World War II： Italians in Rochester, N.Y.

This article examines the major similarities and differences among Italians who migrated to Rochester, N.Y., before World War II and post-World War Ⅱ. It offers explanations on the similarities and differences among these two groups of migrants. Investigation of historical, sociological, and anthropological sources along with interviews among both populations provides abundant data bearing on the investigation. The successful completion of the research reported in this article has major bearing on the issue of migration itself, theories in history, sociology, and anthropology, and even on social psychological understanding of how choices are made and identity is formulated.

Bilding Dmage Level Based According to Distance Image Contrast.

Estimation method of building damage level was introduced for the accurate and effective estimation of damage extent and relief goods demand according to long-distance image contrast. In order to obtain completion degree of building edge extracted from long-distance images before and after disaster, the concentration ratio was analyzed with Hough transformation. Based on the maximum posterior probability, estimation method of affected population was designed to accurately estimate victim population, which can be directly reflected by fugitive population. Moreover, on basis of escape route and fugitive population, demand assignment algorithm by backward calculation was designed to improve rescue efficiency.

EXPERIENCE ON SURGICAL MANAGEMENT OF RUPTURE OF ABDOMINAL AORTIC ANEURYSM

Objective. To describe our surgical experience on rupture of abdominal aortic aneurysm .Methods. Two cases of ruptured aortic aneurysms with severe complication were analyzed. Aorta reconstruction procedures were performed using bifurcated e-PTFE grafts during emergency operation. Diagnosis, preoperadve resuscitation, emergency surgical intervention, and postoperative complications of these patients were summarized and discussed.Results. Rupture of aortic aneurysm in both patients presented as a huge retroperitoneum haematoma by computed tomography scan. They were successfully saved by prompt body fluid compensation, emergency procedure, intraoperative resuscitation, and postoperative intensive care.Conclusions. Correct diagnosis, prompt surgical management, immediate intraoperative proximal aorta clamping during procedure, and effective management of postoperative complications were the key points to successful treatment of ruptured aortic aneurysm.

TCD study of hemodynamic changes in PCA response to photic stimulation

Objectives: During visual stimulation, the elevated metabolism rate will coupl e with increase of blood flow velocity(BFV) in posterior cerebral artery(PCA). T his study with TCD was aimed to investigate whether the coupling might change ac cording to the different vasoneuronal conditions. Methods: Ninety-nine voluntee r s including 24 hypertension(HT) patients and 2 patients suffering from both HT a nd diabetes mellitus(DM) were enrolled in this trial. BFV and pulse indexes(PI) in P2 segments of PCA on both sides were monitored during visual stimulation. Re sults: In all subjects, Mean BFV increased and PI went down in response to visua l stimulation. The percentages of changes (ΔV and ΔP) of both mean BFV and PI we re larger in young group(<55 years old) than in old one(≥55 years old). There w a s significant positive correlation between ΔV and ΔP. Multivariated re gression a nalysis did not show HT and DM, but age related to ΔV(ΔP). We did not find signi ficant difference of ΔV(ΔP) between left and right sides. Conclusions: Blood flo w velocity in PCA P2 segment increased due to decreased cerebrovascular resistan ce during visual stimulation and the response weakened with aging of the patient .

The Palmanova Cantonments： Conservation, Value-Enhancement and Transformation for an Integrated and Overall Regeneration

Italian military real-estate is highly varied as regards its location, intended uses, its typological, stylistic, and constructive features and its state of conservation. What historical and documental value can we attribute to the typological and technical aspects of military buildings？ What problems and strategies have to be studied before such buildings can be repurposed for inclusion into a circuit of social and civil uses？ Some attempts were made to answer these questions by analysing the military real estate of Palmanova, the fortress city founded by the Serenissima Republic of Venice in 1593, a city designed by engineers, military analysts, and expert military architects all answerable to the Fortifications Office of Venice. There are a number of barracks situated inside the city＇s fortified walls, within a somewhat confined area： Montezemolo, Isonzo, Ederle, Filzi, Montesanto and others in outlying villages. Barracks built in different periods （some during the Renaissance, others in the eighteenth century and some even after the Second World War） have been gradually phased out of service. Their restoration and functional leverage, in the early years of this century, were discussed in terms of an economic and cultural strategy that would not upset the city. New regeneration strategies are called for if these abandoned military structures are not to undergo further deterioration. These strategies should be based upon a knowledge of these structures＇ features--their layout, architecture, technologies--and should also embrace local policies, but first and foremost they require real, contextualized and economically sustainable projects.

Postembryonic Development of Electrophysiological Characteristic of Primordial Hippocampus in Bufo bufo gargarizans

[Objective] The aim was to probe into developing changes of spontaneous electrical activities of primordial hippocampus in Bufo bufo gargarizans in postembryonic phase. [Method] Microelectrode technique was used to record extracellularly spontaneous electrical activities of neurons in primordial hippocampus of B.bufo gargarizans in postembryonic phase. [Result] Single, consecutive single, burst, consecutive burst and anomalous spontaneous firing were recorded in primordial hippocampus, in which four kinds of spontaneous firings were recorded in forepart of postembryonic development except the anomalous spontaneous firing, and the burst spontaneous firing and consecutive burst spontaneous firing were predominant. The five kinds of spontaneous firings mentioned were recorded in anaphase of postembryonic development and the single and burst spontaneous firing were predominant.Following with the development of primordial hippocampus, the amplitudes of action potential of single firing and consecutive firing enhanced gradually, and it reaches the maximum in the metamorphosis phase; the differences of the frequencies of consecutive single firing and consecutive burst firing were not significant. [Conclusion] Following with the development of primordial hippocampus, the neuronal electrical activities showed diversification, the developmental degree of the primordial hippocampus in the metamorphosis phase was close to the subadult and adult.

Italian Accounting of the Late 19th Century and the Early 20th Century on the Epistemological Problem of Connections With Related Sciences

This paper takes into consideration the doctrinal positions that are taken by Italian accounting in the period between the 19th and the 20th century, and concerns the nature of relationships between accounting and its most similar sciences, particularly economics. Over those years, the scholars in that field started to show a peculiar epistemological sensitivity. Spurred by the philosophical debate which was raised by positivism and particularly by Comte＇s and Spencer＇s studies, researchers wondered whether the most appropriate place for accounting was in the large field of social sciences. Hence, two different epistemological approaches arose with one succeeding the other in time. Initially, scholars accepted the idea that accounting somehow depended on its related sciences, which included economics. They deemed it convenient to use, also for their own purposes, principles drawn from contiguous doctrines that had already been scientifically recognized, such as economics. That was how Italian accounting happened to be, even though temporarily, in a position of ＂scientific subjection＂ with respect to the mentioned doctrines. At the second stage, due to the awareness of the specific subject and the method of investigation, as well as the purposes, Italian accounting claimed its own scientific autonomy, so scholars went back to the first phase and considered it necessary to develop internal principles and rules as a function of its peculiar needs. By doing so, scholars mapped out a route that would deeply mark the future of the discipline by making it fully independent on other fields of knowledge in a sort of emancipation process. The paper will not only describe the two theoretical positions which are summarized above, but will also adopt an interpretative approach to trace their possible causes and to grasp their effects on the development of the discipline, particularly with regards to the theories of value which is adopted by the Italian accounting over the analyzed period. In the authors＇ opinion, the attention paid by the most authoritative Italian accounting scholars to the epistemological theme of relationships between accounting and its similar sciences can be explained by at least two different causes： the influence which is exercised by the philosophical studies and the aspiration of accounting for scientific and academic recognition.