Total P (TP), total participate P (PP), total dissolved P (TDP), molybdatereactive P (MRP) and dissolved organic P (DOP) were determined in waters from pipe-drains (at 65-cmdepth) from the Broadbalk Experiment at Roth...Total P (TP), total participate P (PP), total dissolved P (TDP), molybdatereactive P (MRP) and dissolved organic P (DOP) were determined in waters from pipe-drains (at 65-cmdepth) from the Broadbalk Experiment at Rothamsted Research, UK. Average TPand PP exceeded 1 mgL^(-1) in about half of the 12 plots receiving superphosphate for the 5 measurements taken betweenDecember 2000 and April 2001. Ranging between 33.8% and 87.3% of TP, PP was the largest P fractionin drainage waters, with DOP, ranging from 0.5% to 26.2% of TP, being the smallest fraction Meanproportions of PP, MRP and DOP in TP in drainage waters were 63.4%, 32.5% and 4.1%, respectively.These findings support previous findings that P losses from soil to drainage waters were muchlargerthan previously thought, and could therefore make a significant contribution to eutrophication.展开更多
In this study the authors aimed to evaluate the oxidative stress enzymes indicative of liver damage in rats exposed to malathion （M）, subchronic form using cimetidine （C） and cimetidine plus malathion （M ＋ C）. ...In this study the authors aimed to evaluate the oxidative stress enzymes indicative of liver damage in rats exposed to malathion （M）, subchronic form using cimetidine （C） and cimetidine plus malathion （M ＋ C）. Malathion, widely used organophosphorus insecticide worldwide, induces oxidative liver damage type; cimetidine is an antagonist of histamine H2-receptor, it has been shown to be an inhibitor of various CYP45o isoforms. Male Wistar rats weighing 200-250 g were studied, exposed to malathion orally for 3 weeks （0.15 mg/kg/day, 2 mg/kg/day, 15 mg/kg/day） and cimetidine 10 mg/kg/day. Malathion plus cimetidine affect susceptibility to oxidative stress and possibly modifies the antioxidant defense capacity directly or indirectly.展开更多
A series of amino organophosphorus imidazoles were designed and synthesized as a novel structural type of antimicrobial agents.Bioactive evaluation in vitro showed that compound 3f exhibited equipotent or superior ant...A series of amino organophosphorus imidazoles were designed and synthesized as a novel structural type of antimicrobial agents.Bioactive evaluation in vitro showed that compound 3f exhibited equipotent or superior anti-methicillin-resistant Staphylococcus aureus(anti-MRSA) and anti-S. cerevisiae efficiencies(minimal inhibitory concentration(MIC)=2 μg/mL) to clinical drugs,and the combinations with antibacterial or antifungal drugs enhanced the antimicrobial efficiency. Highly active molecule 3f showed low propensity for bacteria to develop resistance, and the preliminary action mechanism studies demonstrated that 3f was membrane-active, but had no significant intercalation towards MRSA DNA. The computational study on 3f reasonably explained its high antimicrobial activity. Experimental data revealed that ground-state 3f-HSA complexes were formed mainly through hydrophobic interactions and hydrogen bonds with a spontaneous process, and the non-radioactive energy transfer from HSA to 3f occurred beyond F鰎ster resonance energy transfer theory. The participation of metal ions in 3f-HSA supramolucular system could increase the concentration of free compound 3f, and shorten its storage time and half-life in the blood to improve the maximum antimicrobial efficacy.展开更多
基金Project supported by the Rothamsted International, UK the Scientific Research Foundation for Returned Overseas Chinese Scholars, the State Education Ministry of China and the Natural Science Foundation of Shaanxi Province, China (No. 2002D09).
文摘Total P (TP), total participate P (PP), total dissolved P (TDP), molybdatereactive P (MRP) and dissolved organic P (DOP) were determined in waters from pipe-drains (at 65-cmdepth) from the Broadbalk Experiment at Rothamsted Research, UK. Average TPand PP exceeded 1 mgL^(-1) in about half of the 12 plots receiving superphosphate for the 5 measurements taken betweenDecember 2000 and April 2001. Ranging between 33.8% and 87.3% of TP, PP was the largest P fractionin drainage waters, with DOP, ranging from 0.5% to 26.2% of TP, being the smallest fraction Meanproportions of PP, MRP and DOP in TP in drainage waters were 63.4%, 32.5% and 4.1%, respectively.These findings support previous findings that P losses from soil to drainage waters were muchlargerthan previously thought, and could therefore make a significant contribution to eutrophication.
文摘In this study the authors aimed to evaluate the oxidative stress enzymes indicative of liver damage in rats exposed to malathion （M）, subchronic form using cimetidine （C） and cimetidine plus malathion （M ＋ C）. Malathion, widely used organophosphorus insecticide worldwide, induces oxidative liver damage type; cimetidine is an antagonist of histamine H2-receptor, it has been shown to be an inhibitor of various CYP45o isoforms. Male Wistar rats weighing 200-250 g were studied, exposed to malathion orally for 3 weeks （0.15 mg/kg/day, 2 mg/kg/day, 15 mg/kg/day） and cimetidine 10 mg/kg/day. Malathion plus cimetidine affect susceptibility to oxidative stress and possibly modifies the antioxidant defense capacity directly or indirectly.
基金supported by the National Natural Science Foundation of China(21672173,21372186)Research Fund for International Young Scientists from International(Regional)Cooperation and Exchange Program(81350110523)+1 种基金Chongqing Special Foundation for Postdoctoral Research Proposal(Xm2014127,Xm2016039)Fundamental Research Funds for the Central Universities(XDJK2016E059)
文摘A series of amino organophosphorus imidazoles were designed and synthesized as a novel structural type of antimicrobial agents.Bioactive evaluation in vitro showed that compound 3f exhibited equipotent or superior anti-methicillin-resistant Staphylococcus aureus(anti-MRSA) and anti-S. cerevisiae efficiencies(minimal inhibitory concentration(MIC)=2 μg/mL) to clinical drugs,and the combinations with antibacterial or antifungal drugs enhanced the antimicrobial efficiency. Highly active molecule 3f showed low propensity for bacteria to develop resistance, and the preliminary action mechanism studies demonstrated that 3f was membrane-active, but had no significant intercalation towards MRSA DNA. The computational study on 3f reasonably explained its high antimicrobial activity. Experimental data revealed that ground-state 3f-HSA complexes were formed mainly through hydrophobic interactions and hydrogen bonds with a spontaneous process, and the non-radioactive energy transfer from HSA to 3f occurred beyond F鰎ster resonance energy transfer theory. The participation of metal ions in 3f-HSA supramolucular system could increase the concentration of free compound 3f, and shorten its storage time and half-life in the blood to improve the maximum antimicrobial efficacy.
