Phase behavior of paclitaxel in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated using a supercritical phase monitor.Cloud point pressures were determined as a function of temperat...Phase behavior of paclitaxel in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated using a supercritical phase monitor.Cloud point pressures were determined as a function of temperature,pressure and paclitaxel content from 313.1 to 343.1K and pressures up to 33.52 MPa.The ternary mixtures exhibit a typical lower critical solution temperature behavior.When paclitaxel content increases,the single-phase region shrinks in size.Three cubic equations of state(Redlich-Kworng,Soave-Redlich-Kwong and Peng-Robinson equation of state) coupled with the van der Waals one-fluid mixing rules were selected to correlate the experimental data.The results indicate that SRK EOS coupled with two binary interaction parameters kij and lij can predict paclitaxel solubility for the best fit of experimental data.展开更多
Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried ...Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried out in a semi-dynamic system. Experimental data were correlated by iso-fugacity model(based on cubic equations of state, CEOS), Modified Mendez–Santiago–Teja(MST) and Modified Bartle semi-empirical models. Two cubic equations of state: Peng–Robinson(PR) and Dashtizadeh–Pazuki–Ghotbi–Taghikhani(DPTG) were adopted for calculation of equilibrium parameters in CEOS modeling. Interaction coefficients(k_(ij)& l_(ij)) of van der Waals(vdW) mixing rules were considered as the correlation parameters in CEOS-based modeling and their contribution to the accuracy of model was investigated. Average Absolute Relative Deviation(AARD) between correlated and experimental data was calculated and compared as the index of validity and accuracy for different modeling systems. In this basis it was realized that the semi-empirical equations especially Modified MST can accurately support the theoretical studies on phase equilibrium behavior of quinine–SCCO_2 media. Among the cubic equations of state DPGT within two-parametric vd W mixing rules provided the best data fitting and PR within one-parametric vd W mixing rules demonstrated the highest deviation respecting to the experimental data. Overall, in each individual modeling system the best fitting was observed on the data points attained at 318 K, which could be perhaps due to the moderate thermodynamic state of supercritical phase.展开更多
缺氧是一种临床上十分常见的病理生理现象。几乎所有的呼吸系统疾病和心脏病(尤其是发生心力衰竭时)均会发生缺氧。患者常常表现为呼吸困难、呼吸速率加快、口唇和甲床发绀。然而临床上要想明确患者是否缺氧以及缺氧程度,大多需要抽取...缺氧是一种临床上十分常见的病理生理现象。几乎所有的呼吸系统疾病和心脏病(尤其是发生心力衰竭时)均会发生缺氧。患者常常表现为呼吸困难、呼吸速率加快、口唇和甲床发绀。然而临床上要想明确患者是否缺氧以及缺氧程度,大多需要抽取少量动脉血进行动脉血气分析。目前用于反映机体缺氧的两个指标分别是[1]:动脉血氧分压(PaO2),其定义是血浆中物理溶解状态的氧气产生的压力,正常值为80~100 mm Hg(1 mm Hg=0.133 kPa);动脉血氧饱和度(SaO2),其定义是动脉血中血红蛋白与氧气实际结合的容积/血液中全部血红蛋白所能结合的氧气的最大容积,正常值为95%~98%。展开更多
Natural chromophores wildly exist in living bodies and have been utilized for thousands of years[1].Many of them,such as quinine[2],luciferin[3-5],coelenteramide[6,7],and coumarin[8],can fluoresce and have been widely...Natural chromophores wildly exist in living bodies and have been utilized for thousands of years[1].Many of them,such as quinine[2],luciferin[3-5],coelenteramide[6,7],and coumarin[8],can fluoresce and have been widely applied in biosensor,immune sensor,and fluorescent imaging agents[9,10].展开更多
基金Supported by the National Natural Science Foundation of China （21076084 20676046） the Fundamental Research Funds for the Central Universities （2011ZZ0006）
文摘Phase behavior of paclitaxel in solvent mixtures of dichloromethane and supercritical carbon dioxide was investigated using a supercritical phase monitor.Cloud point pressures were determined as a function of temperature,pressure and paclitaxel content from 313.1 to 343.1K and pressures up to 33.52 MPa.The ternary mixtures exhibit a typical lower critical solution temperature behavior.When paclitaxel content increases,the single-phase region shrinks in size.Three cubic equations of state(Redlich-Kworng,Soave-Redlich-Kwong and Peng-Robinson equation of state) coupled with the van der Waals one-fluid mixing rules were selected to correlate the experimental data.The results indicate that SRK EOS coupled with two binary interaction parameters kij and lij can predict paclitaxel solubility for the best fit of experimental data.
基金Supported by the National Natural Science Foundation of China(20976103)
文摘Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried out in a semi-dynamic system. Experimental data were correlated by iso-fugacity model(based on cubic equations of state, CEOS), Modified Mendez–Santiago–Teja(MST) and Modified Bartle semi-empirical models. Two cubic equations of state: Peng–Robinson(PR) and Dashtizadeh–Pazuki–Ghotbi–Taghikhani(DPTG) were adopted for calculation of equilibrium parameters in CEOS modeling. Interaction coefficients(k_(ij)& l_(ij)) of van der Waals(vdW) mixing rules were considered as the correlation parameters in CEOS-based modeling and their contribution to the accuracy of model was investigated. Average Absolute Relative Deviation(AARD) between correlated and experimental data was calculated and compared as the index of validity and accuracy for different modeling systems. In this basis it was realized that the semi-empirical equations especially Modified MST can accurately support the theoretical studies on phase equilibrium behavior of quinine–SCCO_2 media. Among the cubic equations of state DPGT within two-parametric vd W mixing rules provided the best data fitting and PR within one-parametric vd W mixing rules demonstrated the highest deviation respecting to the experimental data. Overall, in each individual modeling system the best fitting was observed on the data points attained at 318 K, which could be perhaps due to the moderate thermodynamic state of supercritical phase.
文摘缺氧是一种临床上十分常见的病理生理现象。几乎所有的呼吸系统疾病和心脏病(尤其是发生心力衰竭时)均会发生缺氧。患者常常表现为呼吸困难、呼吸速率加快、口唇和甲床发绀。然而临床上要想明确患者是否缺氧以及缺氧程度,大多需要抽取少量动脉血进行动脉血气分析。目前用于反映机体缺氧的两个指标分别是[1]:动脉血氧分压(PaO2),其定义是血浆中物理溶解状态的氧气产生的压力,正常值为80~100 mm Hg(1 mm Hg=0.133 kPa);动脉血氧饱和度(SaO2),其定义是动脉血中血红蛋白与氧气实际结合的容积/血液中全部血红蛋白所能结合的氧气的最大容积,正常值为95%~98%。
基金financially supported by the National Natural Science Foundation of China(22021715 and 52150222)the Major Scientific and Technological Project of the Department of Science&Technology,Zhejiang Province(2020C03030)the support from the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates and the South China University of Technology(2019B030301003)。
文摘Natural chromophores wildly exist in living bodies and have been utilized for thousands of years[1].Many of them,such as quinine[2],luciferin[3-5],coelenteramide[6,7],and coumarin[8],can fluoresce and have been widely applied in biosensor,immune sensor,and fluorescent imaging agents[9,10].
