Psoriasis is a multifactorial disease with a strong genetic background. It associates strongly to HLA-Cw 0602. HLA-C interacts with killer immunoglobulin-like receptors (KIR) on natural killer (NK) and some natural ...Psoriasis is a multifactorial disease with a strong genetic background. It associates strongly to HLA-Cw 0602. HLA-C interacts with killer immunoglobulin-like receptors (KIR) on natural killer (NK) and some natural killer-T cells. KIR’ s function is triggered by specific binding to HLA ligands, which depends on the amino acid 80 of the MHC class Iα -chain. This permits classifying all HLA-C alleles into two functional groups: asparagine (N80) or lysine (K80) carrying alleles. Psoriasis patients recruited at disease onset were categorized as guttate, vulgaris without arthropathy and vulgaris with arthropathy plus skin lesions. Patients and carefully matched controls were genotyped for position 80 of HLA-C and for KIR. Based on possible HLA/KIR combinations, individuals were classified according to expected NK/NKT cell responses: balanced (B), excess inhibition (EI), excess activation (EA), or undetermined (U). HLA-Cw6 and position 80 genotyping associated strongly to disease, whereas KIR2DS1 associated weakly. Individuals of the U and EI classes were more common among guttate psoriasis patients, which related to HLA-Cw 0602 status. These results suggest that different levels for NK/NKT cell activation thresholds, not only reduction, contribute to immune deregulation in psoriasis. In the guttate phenotype, balanced HLA-C/KIR interactions might be altered by the presence of concomitant streptococcal infections.展开更多
目的观察凉血消斑散配合点刺放血治疗急性点滴状银屑病的疗效与安全性。方法将68例患者按照随机数字表法分为观察组和对照组,各34例。观察组采用自拟凉血消斑散配合点刺放血治疗,对照组给予口服罗红霉素分散片治疗,2组均外用蜈黛软膏治...目的观察凉血消斑散配合点刺放血治疗急性点滴状银屑病的疗效与安全性。方法将68例患者按照随机数字表法分为观察组和对照组,各34例。观察组采用自拟凉血消斑散配合点刺放血治疗,对照组给予口服罗红霉素分散片治疗,2组均外用蜈黛软膏治疗,比较2组疗效、治疗前后银屑病面积和严重程度指数(posoriasis area and severity index,PASI)积分、患者不良反应及复发情况。结果观察组总有效率为94.12%,高于对照组的85.30%,差异有统计学意义(P<0.05);治疗前,观察组PASI积分为(17.97±4.42)分,对照组为(18.86±3.64)分,差异无统计学意义(P>0.05);治疗后,观察组PASI积分为(2.97±4.64)分,低于对照组的(12.33±3.87)分,差异有统计学意义(P<0.05)。结论凉血消斑散配合点刺放血治疗急性点滴状银屑病临床效果良好,且安全性高。展开更多
文摘Psoriasis is a multifactorial disease with a strong genetic background. It associates strongly to HLA-Cw 0602. HLA-C interacts with killer immunoglobulin-like receptors (KIR) on natural killer (NK) and some natural killer-T cells. KIR’ s function is triggered by specific binding to HLA ligands, which depends on the amino acid 80 of the MHC class Iα -chain. This permits classifying all HLA-C alleles into two functional groups: asparagine (N80) or lysine (K80) carrying alleles. Psoriasis patients recruited at disease onset were categorized as guttate, vulgaris without arthropathy and vulgaris with arthropathy plus skin lesions. Patients and carefully matched controls were genotyped for position 80 of HLA-C and for KIR. Based on possible HLA/KIR combinations, individuals were classified according to expected NK/NKT cell responses: balanced (B), excess inhibition (EI), excess activation (EA), or undetermined (U). HLA-Cw6 and position 80 genotyping associated strongly to disease, whereas KIR2DS1 associated weakly. Individuals of the U and EI classes were more common among guttate psoriasis patients, which related to HLA-Cw 0602 status. These results suggest that different levels for NK/NKT cell activation thresholds, not only reduction, contribute to immune deregulation in psoriasis. In the guttate phenotype, balanced HLA-C/KIR interactions might be altered by the presence of concomitant streptococcal infections.
文摘目的观察凉血消斑散配合点刺放血治疗急性点滴状银屑病的疗效与安全性。方法将68例患者按照随机数字表法分为观察组和对照组,各34例。观察组采用自拟凉血消斑散配合点刺放血治疗,对照组给予口服罗红霉素分散片治疗,2组均外用蜈黛软膏治疗,比较2组疗效、治疗前后银屑病面积和严重程度指数(posoriasis area and severity index,PASI)积分、患者不良反应及复发情况。结果观察组总有效率为94.12%,高于对照组的85.30%,差异有统计学意义(P<0.05);治疗前,观察组PASI积分为(17.97±4.42)分,对照组为(18.86±3.64)分,差异无统计学意义(P>0.05);治疗后,观察组PASI积分为(2.97±4.64)分,低于对照组的(12.33±3.87)分,差异有统计学意义(P<0.05)。结论凉血消斑散配合点刺放血治疗急性点滴状银屑病临床效果良好,且安全性高。
