目的:探讨甲胎蛋白异质体3 (Alpha fetoprotein Variants 3)等三项肿瘤指标物对不同甲胎蛋白(alpha fetoprotein, AFP)状态下原发性肝癌(primary liver cancer, PLC)的诊断价值。方法:回顾性选取我院门诊和住院的182例乙型肝炎病毒(hepa...目的:探讨甲胎蛋白异质体3 (Alpha fetoprotein Variants 3)等三项肿瘤指标物对不同甲胎蛋白(alpha fetoprotein, AFP)状态下原发性肝癌(primary liver cancer, PLC)的诊断价值。方法:回顾性选取我院门诊和住院的182例乙型肝炎病毒(hepatitis B virus, HBV)感染者为研究对象,将肝癌组分为AFP阳性亚组及AFP阴性亚组,采用受试者工作特征(receiver operating characteristic, ROC)曲线评价不同肿瘤标志物对PLC的诊断效能。结果:血清ALT、AST、ALP、ALB、PLT、PT和INR水平在肝癌组、慢乙肝组以及肝硬化组三组之间有统计学差异(P P > 0.05)。AFP阳性亚组的血清AFP、AFP-L3和AFP-L3%水平均较高,且差异具有统计学意义(P P > 0.05)。无论是AFP阳性亚组还是AFP阴性亚组与非肝癌组相比较时,GP73的水平差别并不显著(P > 0.05)。AFP阳性亚组中,除了AFP外,AFP-L3表现出最高的灵敏度(97.30%)和特异度(84.50%),而在AFP阴性亚组中,AFP-L3%表现出最高的特异度。结论:血清AFP-L3、AFP-L3%水平在AFP阳性亚组时对原发性肝癌的诊断价值较高,血清GP73水平对PLC诊断的价值较低。Objective: Exploring the diagnostic value of three tumor indicators, including alpha fetoprotein Variants 3, for primary liver cancer (PLC) under different alpha fetoprotein (AFP) states. Method: A retrospective study was conducted on 182 patients with hepatitis B virus (HBV) infection in our hospital’s outpatient and inpatient departments. The liver cancer group was divided into AFP positive and AFP negative subgroups, and the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of different tumor markers for PLC. Results: Serum ALT, AST, ALP, ALB, PLT, PT and INR levels were significantly different among the three groups (P P > 0.05). The serum levels of AFP, AFP-L3, and AFP-L3% were higher in the AFP positive subgroup, and the differences were statistically significant (P P > 0.05). The difference in GP73 levels between the AFP positive and AFP negative subgroups and the non liver cancer group was not significant (P > 0.05). In the AFP positive subgroup, besides AFP, AFP-L3 showed the highest sensitivity (97.30%) and specificity (84.50%), while in the AFP negative subgroup, AFP-L3% showed the highest specificity. Conclusion: The diagnostic value of serum AFP-L3 and AFP-L3% levels for primary liver cancer is higher in the AFP positive subgroup, while the diagnostic value of serum GP73 level for PLC is lower.展开更多
目的探讨高尔基体糖蛋白73(GP73)、甲胎蛋白(AFP)及甲胎蛋白异质体3(AFP-L3)3种血清肿瘤标志物在肝癌诊断及射频消融术后复发监测中的应用价值。方法收集2012年7月-2013年10月吉林大学白求恩第一医院住院患者及体检中心健康者174例,其...目的探讨高尔基体糖蛋白73(GP73)、甲胎蛋白(AFP)及甲胎蛋白异质体3(AFP-L3)3种血清肿瘤标志物在肝癌诊断及射频消融术后复发监测中的应用价值。方法收集2012年7月-2013年10月吉林大学白求恩第一医院住院患者及体检中心健康者174例,其中初诊肝癌患者86例,肝硬化患者39例,肝炎患者29例,健康对照20例,并对初诊肝癌的37例患者进行射频消融术后3个月的复诊。分别采用酶联免疫法、电化学发光法、亲和吸附层析法检测血清GP73、AFP、AFP-L3的水平。各组血清标本检测数据呈偏态分布,采用非参数检验,总体比较检验采用Kruskal-Wallis H检验,组间两两比较采用Mann-Whitney U检验,配对秩和检验采用Wilcoxon Signed Ranks检验,计数资料采用χ2检验。结果肝癌组GP73、AFP、AFP-L3表达水平均显著高于其他组(P值均<0.05);肝癌组中GP73和AFP-L3阳性率显著高于其他组(P值均<0.05),而肝癌患者中GP73和AFP-L3阳性率显著高于AFP(P值均<0.05);初诊肝癌的37例患者进行术后3个月复查,AFP-L3复发组术前显著高于未复发组术前(P<0.05)。结论血清GP73、AFP、AFP-L3在肝癌诊断中有重要价值,AFP-L3可以作为鉴别肝病良恶性以及肝癌射频消融术后复发监测的指标。展开更多
文摘目的:探讨甲胎蛋白异质体3 (Alpha fetoprotein Variants 3)等三项肿瘤指标物对不同甲胎蛋白(alpha fetoprotein, AFP)状态下原发性肝癌(primary liver cancer, PLC)的诊断价值。方法:回顾性选取我院门诊和住院的182例乙型肝炎病毒(hepatitis B virus, HBV)感染者为研究对象,将肝癌组分为AFP阳性亚组及AFP阴性亚组,采用受试者工作特征(receiver operating characteristic, ROC)曲线评价不同肿瘤标志物对PLC的诊断效能。结果:血清ALT、AST、ALP、ALB、PLT、PT和INR水平在肝癌组、慢乙肝组以及肝硬化组三组之间有统计学差异(P P > 0.05)。AFP阳性亚组的血清AFP、AFP-L3和AFP-L3%水平均较高,且差异具有统计学意义(P P > 0.05)。无论是AFP阳性亚组还是AFP阴性亚组与非肝癌组相比较时,GP73的水平差别并不显著(P > 0.05)。AFP阳性亚组中,除了AFP外,AFP-L3表现出最高的灵敏度(97.30%)和特异度(84.50%),而在AFP阴性亚组中,AFP-L3%表现出最高的特异度。结论:血清AFP-L3、AFP-L3%水平在AFP阳性亚组时对原发性肝癌的诊断价值较高,血清GP73水平对PLC诊断的价值较低。Objective: Exploring the diagnostic value of three tumor indicators, including alpha fetoprotein Variants 3, for primary liver cancer (PLC) under different alpha fetoprotein (AFP) states. Method: A retrospective study was conducted on 182 patients with hepatitis B virus (HBV) infection in our hospital’s outpatient and inpatient departments. The liver cancer group was divided into AFP positive and AFP negative subgroups, and the receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of different tumor markers for PLC. Results: Serum ALT, AST, ALP, ALB, PLT, PT and INR levels were significantly different among the three groups (P P > 0.05). The serum levels of AFP, AFP-L3, and AFP-L3% were higher in the AFP positive subgroup, and the differences were statistically significant (P P > 0.05). The difference in GP73 levels between the AFP positive and AFP negative subgroups and the non liver cancer group was not significant (P > 0.05). In the AFP positive subgroup, besides AFP, AFP-L3 showed the highest sensitivity (97.30%) and specificity (84.50%), while in the AFP negative subgroup, AFP-L3% showed the highest specificity. Conclusion: The diagnostic value of serum AFP-L3 and AFP-L3% levels for primary liver cancer is higher in the AFP positive subgroup, while the diagnostic value of serum GP73 level for PLC is lower.
文摘目的探讨高尔基体糖蛋白73(GP73)、甲胎蛋白(AFP)及甲胎蛋白异质体3(AFP-L3)3种血清肿瘤标志物在肝癌诊断及射频消融术后复发监测中的应用价值。方法收集2012年7月-2013年10月吉林大学白求恩第一医院住院患者及体检中心健康者174例,其中初诊肝癌患者86例,肝硬化患者39例,肝炎患者29例,健康对照20例,并对初诊肝癌的37例患者进行射频消融术后3个月的复诊。分别采用酶联免疫法、电化学发光法、亲和吸附层析法检测血清GP73、AFP、AFP-L3的水平。各组血清标本检测数据呈偏态分布,采用非参数检验,总体比较检验采用Kruskal-Wallis H检验,组间两两比较采用Mann-Whitney U检验,配对秩和检验采用Wilcoxon Signed Ranks检验,计数资料采用χ2检验。结果肝癌组GP73、AFP、AFP-L3表达水平均显著高于其他组(P值均<0.05);肝癌组中GP73和AFP-L3阳性率显著高于其他组(P值均<0.05),而肝癌患者中GP73和AFP-L3阳性率显著高于AFP(P值均<0.05);初诊肝癌的37例患者进行术后3个月复查,AFP-L3复发组术前显著高于未复发组术前(P<0.05)。结论血清GP73、AFP、AFP-L3在肝癌诊断中有重要价值,AFP-L3可以作为鉴别肝病良恶性以及肝癌射频消融术后复发监测的指标。
