眼表疾病,包括干眼、角膜上皮缺损、神经营养性角膜病变、糖尿病角膜病变等,严重威胁患者的视力,影响患者的生活质量。胰岛素是一种多功能的生长因子,主要用于调节血糖,而局部胰岛素作为一种经济实惠的治疗方法,近年来研究发现其能够促...眼表疾病,包括干眼、角膜上皮缺损、神经营养性角膜病变、糖尿病角膜病变等,严重威胁患者的视力,影响患者的生活质量。胰岛素是一种多功能的生长因子,主要用于调节血糖,而局部胰岛素作为一种经济实惠的治疗方法,近年来研究发现其能够促进角膜伤口愈合、抑制炎症反应并保护角膜神经,有效改善眼表疾病的治疗现状。本文综述了外用胰岛素在眼表疾病治疗中的研究进展,从实验研究到临床试验探讨其治疗潜能和机制,分析了外用胰岛素治疗眼表疾病的剂型,阐释其疗效评估和安全性监测。Eye surface diseases seriously threaten vision of patients and affect their quality of life, including dry eye diseases, corneal epithelial defects, neurotrophic keratopathy, and diabetic keratopathy. Insulin, a multifunctional growth factor primarily used to regulate the level of blood glucose, has emerged as an effective and economical treatment in recent years. Extensive studies suggest that insulin is able to promote corneal wound healing, suppress inflammatory responses, and protect corneal nerves, thereby improving the treatment of eye surface diseases. This review summarizes the research progress of topical insulin in the treatment of eye surface diseases, discussing its therapeutic potential and mechanisms from experimental studies to clinical trials. Moreover, the review analyzes the formulations of topical insulin for treating eye surface diseases, elucidating its efficacy evaluation and safety monitoring.展开更多
任何眼表疾病均可影响患眼的视觉质量,同时也会干扰角膜屈光手术和屈光性白内障手术前的检查和生物测量。此外,眼科手术也会引起或加重眼表功能或结构的异常,导致视力下降,患者术后满意度低。目前干眼等眼表疾病对各种眼部手术效果的影...任何眼表疾病均可影响患眼的视觉质量,同时也会干扰角膜屈光手术和屈光性白内障手术前的检查和生物测量。此外,眼科手术也会引起或加重眼表功能或结构的异常,导致视力下降,患者术后满意度低。目前干眼等眼表疾病对各种眼部手术效果的影响已引起眼科医师的广泛关注,但很多眼科医师对最新的相关诊疗指南尚不了解,未及时对前沿概念、诊断方法和治疗手段进行更新。为此,美国白内障与屈光手术学会(ASCRS)角膜委员会在Journal of Cataract&Refractive Surgery杂志发布了首个角膜屈光手术和屈光性白内障手术术前眼表疾病的诊疗临床路径,为术者在屈光性手术前合理有效地处理眼表异常提供指导。本文对《ASCRS屈光性手术前眼表疾病诊疗临床路径》进行翻译和解读,以提高眼科医师对围手术期眼表疾病,尤其是对干眼的认识和诊疗水平,进一步改善手术效果和术后术眼的视觉质量,提高患者满意度。展开更多
文摘眼表疾病,包括干眼、角膜上皮缺损、神经营养性角膜病变、糖尿病角膜病变等,严重威胁患者的视力,影响患者的生活质量。胰岛素是一种多功能的生长因子,主要用于调节血糖,而局部胰岛素作为一种经济实惠的治疗方法,近年来研究发现其能够促进角膜伤口愈合、抑制炎症反应并保护角膜神经,有效改善眼表疾病的治疗现状。本文综述了外用胰岛素在眼表疾病治疗中的研究进展,从实验研究到临床试验探讨其治疗潜能和机制,分析了外用胰岛素治疗眼表疾病的剂型,阐释其疗效评估和安全性监测。Eye surface diseases seriously threaten vision of patients and affect their quality of life, including dry eye diseases, corneal epithelial defects, neurotrophic keratopathy, and diabetic keratopathy. Insulin, a multifunctional growth factor primarily used to regulate the level of blood glucose, has emerged as an effective and economical treatment in recent years. Extensive studies suggest that insulin is able to promote corneal wound healing, suppress inflammatory responses, and protect corneal nerves, thereby improving the treatment of eye surface diseases. This review summarizes the research progress of topical insulin in the treatment of eye surface diseases, discussing its therapeutic potential and mechanisms from experimental studies to clinical trials. Moreover, the review analyzes the formulations of topical insulin for treating eye surface diseases, elucidating its efficacy evaluation and safety monitoring.
文摘任何眼表疾病均可影响患眼的视觉质量,同时也会干扰角膜屈光手术和屈光性白内障手术前的检查和生物测量。此外,眼科手术也会引起或加重眼表功能或结构的异常,导致视力下降,患者术后满意度低。目前干眼等眼表疾病对各种眼部手术效果的影响已引起眼科医师的广泛关注,但很多眼科医师对最新的相关诊疗指南尚不了解,未及时对前沿概念、诊断方法和治疗手段进行更新。为此,美国白内障与屈光手术学会(ASCRS)角膜委员会在Journal of Cataract&Refractive Surgery杂志发布了首个角膜屈光手术和屈光性白内障手术术前眼表疾病的诊疗临床路径,为术者在屈光性手术前合理有效地处理眼表异常提供指导。本文对《ASCRS屈光性手术前眼表疾病诊疗临床路径》进行翻译和解读,以提高眼科医师对围手术期眼表疾病,尤其是对干眼的认识和诊疗水平,进一步改善手术效果和术后术眼的视觉质量,提高患者满意度。
