目的:运用网状Meta分析评价中成药治疗心脏神经官能症的疗效。方法:检索PubMed、Web of Science、EMbase、the Cochrane Library、中国知网、万方、维普,从建库至2023年4月1日中成药治疗心脏神经官能症的随机对照试验。运用RoB2进行偏...目的:运用网状Meta分析评价中成药治疗心脏神经官能症的疗效。方法:检索PubMed、Web of Science、EMbase、the Cochrane Library、中国知网、万方、维普,从建库至2023年4月1日中成药治疗心脏神经官能症的随机对照试验。运用RoB2进行偏倚风险评价、Stata 17SE进行网状Meta分析。结果:共纳入48篇文献,涉及稳心颗粒、舒肝解郁胶囊、参松养心胶囊、心可舒片、养心氏片、逍遥丸、益心舒胶囊、乌灵胶囊和柏子养心丸共9种中成药。网状Meta分析结果显示:总有效率方面最佳为舒肝解郁胶囊;改善躯体化症状方面稳心颗粒最佳;改善焦虑方面心可舒片最佳;改善抑郁方面益心舒胶囊最佳。结论:现有证据表明,中成药联合西医常规治疗心脏神经官能症的疗效优于单用西医常规治疗。展开更多
目的:基于网络药理学结合分子对接探究甘麦大枣汤治疗心脏神经官能症的作用机制。方法:通过检索中药系统药理学(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)数据库获取活性成分靶标信息...目的:基于网络药理学结合分子对接探究甘麦大枣汤治疗心脏神经官能症的作用机制。方法:通过检索中药系统药理学(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)数据库获取活性成分靶标信息,挖掘GeneCards数据库构建疾病靶点。运用STRING(https://string-db.org/)数据库来构建蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络模型,用Cytoscape 3.8.2可视化分析。采用在线分析平台DAVID v6.8对关键靶点进行京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)信号通路富集分析和基因本体(gene ontology,GO)富集分析。用R包绘制KEGG信号通路和GO富集分析图。利用AutoDock Vina,Pymol 2.0.1,Openbable3.1.1等软件完成分子对接。结果:甘麦大枣汤中共有107种包括槲皮素、木犀草素、山奈酚、柚皮素、异鼠李素等具有重要生物学作用的活性成分,作用于包括STAT3、JUN、TNF、TPT53、AKT1、EGFR在内的203个疾病药物治疗的潜在靶点。且广泛富集于TNF、HIF-1和Toll样受体的一系列信号通路中,核心活性成分也与核心靶点紧密结合。结论:甘麦大枣汤中黄酮类、三萜类及酚类等成分能与心脏神经官能症的疾病靶点稳定结合,进一步证实了该方剂通过多成分、多靶点、多通路治疗官能症、脏躁、抑郁、焦虑等症,这为中医药治疗心脏神经官能症提供了科学依据和参考。展开更多
心脏神经官能症(CN)是一种以心血管系统功能失常为主要表现的神经官能症,更年期妇女被发现是本病高发人群。现代医学对其发病机制仍不明确,治疗上亦存在药物不良反应众多,患者依从性差等问题。中医辨证治疗本病历史悠久,治法众多,笔者...心脏神经官能症(CN)是一种以心血管系统功能失常为主要表现的神经官能症,更年期妇女被发现是本病高发人群。现代医学对其发病机制仍不明确,治疗上亦存在药物不良反应众多,患者依从性差等问题。中医辨证治疗本病历史悠久,治法众多,笔者通过综述近年来现代中医对CN的研究现状发现,目前大部分学者认为CN主要病机为肝郁脾虚,心胆气虚等,常用治疗措施有辨证论治使用中药汤剂或中成药,针刺也是CN患者常用外治法。多项临床研究表明,中医药治疗CN患者疗效确切,可以显著改善患者症状,减轻其焦虑抑郁等负性情绪,提高患者的生活质量,且具有较高的安全性,值得临床推广应用。Cardiac neurosis (CN) is a type of neurosis primarily manifested by dysfunction of the cardiovascular system, with postmenopausal women identified as a high-risk group. The pathogenesis of this condition remains unclear in modern medicine, and treatment options are often associated with numerous adverse drug reactions and poor patient adherence. Traditional Chinese medicine (TCM) has a long history of treating CN through syndrome differentiation, with a variety of therapeutic approaches available. By reviewing the current research status of CN in modern TCM, the author finds that most scholars currently believe that the main pathogenesis of CN involves liver stagnation and spleen deficiency, as well as heart and gallbladder qi deficiency. Common treatment measures include syndrome differentiation and treatment with decoctions or proprietary Chinese medicines, while acupuncture is also a commonly used external therapy for CN patients. Multiple clinical studies have shown that TCM treatment for CN patients is effective, significantly improving symptoms, reducing negative emotions such as anxiety and depression, and enhancing patients’ quality of life. Furthermore, it exhibits high safety, making it worthy of clinical promotion and application.展开更多
文摘目的:基于网络药理学结合分子对接探究甘麦大枣汤治疗心脏神经官能症的作用机制。方法:通过检索中药系统药理学(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP)数据库获取活性成分靶标信息,挖掘GeneCards数据库构建疾病靶点。运用STRING(https://string-db.org/)数据库来构建蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络模型,用Cytoscape 3.8.2可视化分析。采用在线分析平台DAVID v6.8对关键靶点进行京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)信号通路富集分析和基因本体(gene ontology,GO)富集分析。用R包绘制KEGG信号通路和GO富集分析图。利用AutoDock Vina,Pymol 2.0.1,Openbable3.1.1等软件完成分子对接。结果:甘麦大枣汤中共有107种包括槲皮素、木犀草素、山奈酚、柚皮素、异鼠李素等具有重要生物学作用的活性成分,作用于包括STAT3、JUN、TNF、TPT53、AKT1、EGFR在内的203个疾病药物治疗的潜在靶点。且广泛富集于TNF、HIF-1和Toll样受体的一系列信号通路中,核心活性成分也与核心靶点紧密结合。结论:甘麦大枣汤中黄酮类、三萜类及酚类等成分能与心脏神经官能症的疾病靶点稳定结合,进一步证实了该方剂通过多成分、多靶点、多通路治疗官能症、脏躁、抑郁、焦虑等症,这为中医药治疗心脏神经官能症提供了科学依据和参考。
文摘心脏神经官能症(CN)是一种以心血管系统功能失常为主要表现的神经官能症,更年期妇女被发现是本病高发人群。现代医学对其发病机制仍不明确,治疗上亦存在药物不良反应众多,患者依从性差等问题。中医辨证治疗本病历史悠久,治法众多,笔者通过综述近年来现代中医对CN的研究现状发现,目前大部分学者认为CN主要病机为肝郁脾虚,心胆气虚等,常用治疗措施有辨证论治使用中药汤剂或中成药,针刺也是CN患者常用外治法。多项临床研究表明,中医药治疗CN患者疗效确切,可以显著改善患者症状,减轻其焦虑抑郁等负性情绪,提高患者的生活质量,且具有较高的安全性,值得临床推广应用。Cardiac neurosis (CN) is a type of neurosis primarily manifested by dysfunction of the cardiovascular system, with postmenopausal women identified as a high-risk group. The pathogenesis of this condition remains unclear in modern medicine, and treatment options are often associated with numerous adverse drug reactions and poor patient adherence. Traditional Chinese medicine (TCM) has a long history of treating CN through syndrome differentiation, with a variety of therapeutic approaches available. By reviewing the current research status of CN in modern TCM, the author finds that most scholars currently believe that the main pathogenesis of CN involves liver stagnation and spleen deficiency, as well as heart and gallbladder qi deficiency. Common treatment measures include syndrome differentiation and treatment with decoctions or proprietary Chinese medicines, while acupuncture is also a commonly used external therapy for CN patients. Multiple clinical studies have shown that TCM treatment for CN patients is effective, significantly improving symptoms, reducing negative emotions such as anxiety and depression, and enhancing patients’ quality of life. Furthermore, it exhibits high safety, making it worthy of clinical promotion and application.
