Dipivefrin hydrochloride ophthalmic gel was prepared and the release test and the isolated cornea permeation test of the formulation in vitro were investigated. The release test of the formulation was studied by using...Dipivefrin hydrochloride ophthalmic gel was prepared and the release test and the isolated cornea permeation test of the formulation in vitro were investigated. The release test of the formulation was studied by using permeable membrane. The content and the release amount of Dipivefrin hydrochloride from the gel base were measured by high performance liquid chromatography. The cornea permeation test of the formulation was studied by using isolated rabbit corneas. The formulation release behavior in vitro followed the first-order kinetic equation. The release amount of Dipivefrin hydrochloride raised significantly with less polymer in the formulation. The cornea permeation behavior of the drug in vitro followed the first-order kinetic equation. The eye irritancy of Dipivefrin hydrochloride gel is lower than that of eyedrops.展开更多
Ionic liquids (ILs) are green solvents that have attracted great attention in recent years due to their unique properties. In this paper the latest progresses in both the fundamental studies and applications of ILs ...Ionic liquids (ILs) are green solvents that have attracted great attention in recent years due to their unique properties. In this paper the latest progresses in both the fundamental studies and applications of ILs have been summarized, with the emphasis on the topics of physical properties, catalytic reactions, and biochemical engineering. The critical problems in the applications of the ILs have been addresses, and the prospective of the ILs were finally predicted.展开更多
文摘Dipivefrin hydrochloride ophthalmic gel was prepared and the release test and the isolated cornea permeation test of the formulation in vitro were investigated. The release test of the formulation was studied by using permeable membrane. The content and the release amount of Dipivefrin hydrochloride from the gel base were measured by high performance liquid chromatography. The cornea permeation test of the formulation was studied by using isolated rabbit corneas. The formulation release behavior in vitro followed the first-order kinetic equation. The release amount of Dipivefrin hydrochloride raised significantly with less polymer in the formulation. The cornea permeation behavior of the drug in vitro followed the first-order kinetic equation. The eye irritancy of Dipivefrin hydrochloride gel is lower than that of eyedrops.
文摘Ionic liquids (ILs) are green solvents that have attracted great attention in recent years due to their unique properties. In this paper the latest progresses in both the fundamental studies and applications of ILs have been summarized, with the emphasis on the topics of physical properties, catalytic reactions, and biochemical engineering. The critical problems in the applications of the ILs have been addresses, and the prospective of the ILs were finally predicted.