目的探讨Toll样受体4（TLR4）基因Asp299Gly多态性与脑膜炎球菌病易感性的关系。方法检索Pubmed,Cohrance,Embase,CNKI,维普,万方等数据平台从建库截止到2015年12月31日的文献,搜寻符合纳入和排除条件的随机对照研究,Rev Man5.0.0软件进...目的探讨Toll样受体4（TLR4）基因Asp299Gly多态性与脑膜炎球菌病易感性的关系。方法检索Pubmed,Cohrance,Embase,CNKI,维普,万方等数据平台从建库截止到2015年12月31日的文献,搜寻符合纳入和排除条件的随机对照研究,Rev Man5.0.0软件进行Meta分析。结果共纳入4篇文献,样本总量3 707例,其中研究组1 681例,对照组2 026例。Meta分析未见TLR4基因Asp299Gly多态性与脑膜炎球菌病易感性相关（等位基因A vs G∶OR=1.01,95%CI=0.84-1.23,P=0.89;基因型AA/AG vs GG∶OR=1.05,95%CI=0.55-2.02,P=0.87;基因型AA vs AG/GG∶OR=1.01,95%CI=0.82-1.24,P=0.95）。结论未见TLR4基因Asp299Gly多态性与脑膜炎球菌病易感性相关。展开更多
Objective: To examine biological and social risk factors for meningococcal disease in adolescents. Design: Prospective, population based, matched cohort study with controls matched for age and sex in 1:1 matching. Con...Objective: To examine biological and social risk factors for meningococcal disease in adolescents. Design: Prospective, population based, matched cohort study with controls matched for age and sex in 1:1 matching. Controls were sought from the general practitioner. Setting: Six contiguous regions of England, which represent some 65% of the country’ s population. Participants: 15-19 year olds with meningococcal disease recruited at hospital admission in six regions (representing 65% of the population of England) from January 1999 to June 2000, and their matched controls. Methods: Blood samples and pernasal and throat swabs were taken from case patients at admission to hospital and from cases and matched controls at interview. Data on potential risk factors were gathered by confidential interview. Data were analysed by using univariate and multivariate conditional logistic regression. Results: 144 case control pairs were recruited (74 male (51% ); median age 17.6). 114 cases (79% ) were confirmed microbiologically. Significant independent risk factors for meningococcal disease were history of preceding illness (matched odds ratio 2.9, 95% confidence interval 1.4 to 5.9), intimate kissing with multiple partners (3.7, 1.7 to 8.1), being a university student (3.4, 1.2 to 10) and preterm birth (3.7, 1.0 to 13.5). Religious observance (0.09, 0.02 to 0.6) and meningococcal vaccination (0.12, 0.04 to 0.4) were associated with protection. Conclusions: Activities and events increasing risk for meningococcal disease in adolescence are different from risks in childhood. Students are at higher risk. Altering personal behaviours could moderate the risk. However, the development of further effective meningococcal vaccines remains a key public health priority.展开更多
Meningococcal disease due to Neisseria meningitidis of serogroup W135 (N.meningitidis W135) is increasing in France.Clinical and outcome data concerning these infections in children are scarce.We report five cases of ...Meningococcal disease due to Neisseria meningitidis of serogroup W135 (N.meningitidis W135) is increasing in France.Clinical and outcome data concerning these infections in children are scarce.We report five cases of children hospitalized between June 2000 and December 2002 for N.meningitidis W135 infection.Extra-meningeal septic and/or non-septic complications were frequent and a prolonged postmeningococcal inflammatory syndrome was reported.In N.meningitidis W135 infections a careful clinical evaluation of potential extrameningeal complications and a long term follow up of children are needed.展开更多
2010年3月10－31日，美国俄克拉荷马州卫生署（Oklahoma State Department of Health，OSDH）调查了一起脑膜炎球菌（Neisseria Meningitidis，Nm）病爆发疫情，该疫情波及了俄克拉荷马卅I东北部农村地区拥有1850名学生的联合学校。该...2010年3月10－31日，美国俄克拉荷马州卫生署（Oklahoma State Department of Health，OSDH）调查了一起脑膜炎球菌（Neisseria Meningitidis，Nm）病爆发疫情，该疫情波及了俄克拉荷马卅I东北部农村地区拥有1850名学生的联合学校。该爆发确定后，展开更多
文摘目的探讨Toll样受体4（TLR4）基因Asp299Gly多态性与脑膜炎球菌病易感性的关系。方法检索Pubmed,Cohrance,Embase,CNKI,维普,万方等数据平台从建库截止到2015年12月31日的文献,搜寻符合纳入和排除条件的随机对照研究,Rev Man5.0.0软件进行Meta分析。结果共纳入4篇文献,样本总量3 707例,其中研究组1 681例,对照组2 026例。Meta分析未见TLR4基因Asp299Gly多态性与脑膜炎球菌病易感性相关（等位基因A vs G∶OR=1.01,95%CI=0.84-1.23,P=0.89;基因型AA/AG vs GG∶OR=1.05,95%CI=0.55-2.02,P=0.87;基因型AA vs AG/GG∶OR=1.01,95%CI=0.82-1.24,P=0.95）。结论未见TLR4基因Asp299Gly多态性与脑膜炎球菌病易感性相关。
文摘Objective: To examine biological and social risk factors for meningococcal disease in adolescents. Design: Prospective, population based, matched cohort study with controls matched for age and sex in 1:1 matching. Controls were sought from the general practitioner. Setting: Six contiguous regions of England, which represent some 65% of the country’ s population. Participants: 15-19 year olds with meningococcal disease recruited at hospital admission in six regions (representing 65% of the population of England) from January 1999 to June 2000, and their matched controls. Methods: Blood samples and pernasal and throat swabs were taken from case patients at admission to hospital and from cases and matched controls at interview. Data on potential risk factors were gathered by confidential interview. Data were analysed by using univariate and multivariate conditional logistic regression. Results: 144 case control pairs were recruited (74 male (51% ); median age 17.6). 114 cases (79% ) were confirmed microbiologically. Significant independent risk factors for meningococcal disease were history of preceding illness (matched odds ratio 2.9, 95% confidence interval 1.4 to 5.9), intimate kissing with multiple partners (3.7, 1.7 to 8.1), being a university student (3.4, 1.2 to 10) and preterm birth (3.7, 1.0 to 13.5). Religious observance (0.09, 0.02 to 0.6) and meningococcal vaccination (0.12, 0.04 to 0.4) were associated with protection. Conclusions: Activities and events increasing risk for meningococcal disease in adolescence are different from risks in childhood. Students are at higher risk. Altering personal behaviours could moderate the risk. However, the development of further effective meningococcal vaccines remains a key public health priority.
文摘Meningococcal disease due to Neisseria meningitidis of serogroup W135 (N.meningitidis W135) is increasing in France.Clinical and outcome data concerning these infections in children are scarce.We report five cases of children hospitalized between June 2000 and December 2002 for N.meningitidis W135 infection.Extra-meningeal septic and/or non-septic complications were frequent and a prolonged postmeningococcal inflammatory syndrome was reported.In N.meningitidis W135 infections a careful clinical evaluation of potential extrameningeal complications and a long term follow up of children are needed.
文摘2010年3月10－31日，美国俄克拉荷马州卫生署（Oklahoma State Department of Health，OSDH）调查了一起脑膜炎球菌（Neisseria Meningitidis，Nm）病爆发疫情，该疫情波及了俄克拉荷马卅I东北部农村地区拥有1850名学生的联合学校。该爆发确定后，
