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杭州湾海底输油管道负压保护方案 被引量:1
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作者 李保国 杨常国 韩飞 《油气储运》 CAS 北大核心 2007年第12期60-61,共2页
以杭州湾海底管道为例,分析了海底管道漏油的原因,提出了海底管道负压保护方案。通过海底管道内压试验并综合改进设备选型和费用的基本估算,指出杭州湾海底输油管道采用负压保护是可行的,能有效防止管道溢油事故的发生。
关键词 海底输油管道 泄漏 防治 负压保护 试验 可行性分析
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自制手术用负压保护罩在神经外科开颅手术中的应用
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作者 张皖生 刘红松 《医院与医学》 2021年第3期70-73,共4页
目的探讨自制手术用负压保护罩在神经外科开颅手术中的应用效果。方法选取湖州市中心医院2020年1月至2020年10月在该院施行神经外科开颅手术的患者120名作为研究对象。按照随机数字表将入选患者随机分组:试验组和对照组各60名患者。实... 目的探讨自制手术用负压保护罩在神经外科开颅手术中的应用效果。方法选取湖州市中心医院2020年1月至2020年10月在该院施行神经外科开颅手术的患者120名作为研究对象。按照随机数字表将入选患者随机分组:试验组和对照组各60名患者。实验组患者手术中使用自制手术用负压保护罩,对照组患者手术中使用常规负压吸引装置。比较两组患者手术时气溶胶清除率、手术停止操作次数及开颅时间的差异。结果实验组气溶胶清除率(78.87±4.60)高于对照组(66.05±7.33),差异有统计学意义(P<0.05);实验组手术停止操作次数(2.033±0.843)低于对照组(2.383±0.976),差异有统计学意义(P<0.05);实验组开颅时间(10.85±2.52)分钟,低于对照组(11.85±2.58)分钟,差异有统计学意义(P<0.05);结论自制手术用负压保护罩临床使用效果良好,能有效清除开颅手术中产生的气溶胶,减少手术停止操作次数,缩短开颅时间,值得推荐应用。 展开更多
关键词 气溶胶 开颅手术 负压保护
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口服固体制剂生产原辅料称量的负压保护装置及其选用
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作者 吴云琦 《机电信息》 2014年第5期23-25,共3页
从法规与相关文献的要求入手,以口服固体制剂生产为例,探讨了由上海东富龙德惠净化空调工程安装有限公司生产的原辅料称量负压保护装置,阐述了其原理,并探讨了其选用与验证要点。
关键词 口服固体制剂 原辅料称量 负压保护装置 原理 选用 粉尘污染
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Hypertrophic preconditioning attenuates myocardial ischemia/reperfusion injury through the deacetylation of isocitrate dehydrogenase 2 被引量:2
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作者 Leilei Ma Hongtao Shi +7 位作者 Yang Li Wei Gao Junjie Guo Jianbing Zhu Zheng Dong Aijun Sun Yunzeng Zou Junbo Ge 《Science Bulletin》 SCIE EI CSCD 2021年第20期2099-2114,M0004,共17页
To test the hypothesis that transient nonischemic stimulation of hypertrophy would render the heart resistant to subsequent ischemic stress,short-term transverse aortic constriction(TAC)was performed in mice and then ... To test the hypothesis that transient nonischemic stimulation of hypertrophy would render the heart resistant to subsequent ischemic stress,short-term transverse aortic constriction(TAC)was performed in mice and then withdrawn for several days by aortic debanding,followed by subsequent myocardial exposure to ischemia/reperfusion(I/R).Following I/R injury,the myocardial infarct size and apoptosis were markedly reduced,and contractile function was significantly improved in the TAC preconditioning group compared with the control group.Mechanistically,hypertrophic preconditioning remarkably alleviated I/R-induced oxidative stress,as evidenced by the increased reduced nicotinamide adenine dinucleotide phosphate(NADPH)/nicotinamide adenine dinucleotide phosphate(NADP)ratio,increase in the reduced glutathione(GSH)/oxidized glutathione(GSSH)ratio,and reduced mitochondrial reactive oxygen species(ROS)production.Moreover,TAC preconditioning inhibited caspase-3 activation and mitigated the mitochondrial impairment by deacetylating isocitrate dehydrogenase 2(IDH2)via a sirtuin 3(SIRT3)-dependent mechanism.In addition,the expression of a genetic deacetylation mimetic IDH2 mutant(IDH2 K413R)in cardiomyocytes,which increased IDH2 enzymatic activity and decreased mitochondrial ROS production,and ameliorated I/R injury,whereas the expression of a genetic acetylation mimetic(IDH2 K413Q)in cardiomyocytes abolished these protective effects of hypertrophic preconditioning.Furthermore,both the activity and expression of the SIRT3 protein were markedly increased in preconditioned mice exposed to I/R.Treatment with an adenovirus encoding SIRT3 partially emulated the actions of hypertrophic preconditioning,whereas genetic ablation of SIRT3 in mice blocked the cardioprotective effects of hypertrophic preconditioning.The present study identifies hypertrophic preconditioning as a novel endogenous self-defensive and cardioprotective strategy for cardiac I/R injury that induces IDH2 deacetylation through a SIRT3-dependent mechanism.A therapeutic strategy targeting IDH2 may be a promising treatment for cardiac ischemic injury. 展开更多
关键词 Ischemia/reperfusion injury Hypertrophic preconditioning SIRT3 IDH2 ACETYLATION
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