BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface barrier.Notably,these enzymes p...BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface barrier.Notably,these enzymes play a significant role in the development of diverse tumors.AIM To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression Omnibus.The study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and PLA2G12B.Gene Set Enrichment Analysis was utilized to pinpoint associated pathways.Moreover,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was evaluated.RESULTS PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy individuals.Elevated expression of PLA2G2A was correlated with poorer overall survival in CCA patients.Additionally,the study delineated pathways and miRNAs associated with these genes.CONCLUSION Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for CCA.The increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.展开更多
随着新型电力系统建设和“双碳目标”的发展,分布式新能源和灵活性负荷在配电网中的渗透率越来越高,主动配电网的低碳经济调度面临巨大挑战。考虑系统碳排放的同时考虑车辆到电站(vehicle-to-grid,V2G)的储能特性,建立了电动汽车有序充...随着新型电力系统建设和“双碳目标”的发展,分布式新能源和灵活性负荷在配电网中的渗透率越来越高,主动配电网的低碳经济调度面临巨大挑战。考虑系统碳排放的同时考虑车辆到电站(vehicle-to-grid,V2G)的储能特性,建立了电动汽车有序充放电模型。基于可转移负荷和可中断负荷进行负荷需求响应建模,并对配电网支路潮流约束进行二阶锥松弛处理,以主动配电网调度成本最小为目标构建了一种考虑V2G储能特性与负荷需求响应的主动配电网日前低碳经济调度模型;计及风光出力不确定性得到主动配电网低碳鲁棒调度模型并采用行列生成算法(column and constraint generation,CCG)算法进行求解,以保证最坏场景的碳排放在允许范围以内。采用IEEE 33节点配电系统算例进行了验证,结果表明,所提模型能够有效降低主动配电网的调度成本和碳排放量。展开更多
快速可行的灾后恢复是弹性电力系统的重要一环。提出一种弹性导向的考虑修复不确定性和V2G(vehicle to grid,V2G)的城市电力系统动态供电恢复方法,灾后短期内应用V2G站中的有限电动汽车资源为城市电网提供电能支撑,同时派遣抢修队对故...快速可行的灾后恢复是弹性电力系统的重要一环。提出一种弹性导向的考虑修复不确定性和V2G(vehicle to grid,V2G)的城市电力系统动态供电恢复方法,灾后短期内应用V2G站中的有限电动汽车资源为城市电网提供电能支撑,同时派遣抢修队对故障线路进行抢修作业,实现系统快速恢复。对V2G和电动汽车灾前、灾后行为进行建模,通过灾前自由调度统计各V2G站附近的电动汽车数量,按照响应意愿比例得到灾后阶段各V2G站反向输电功率;对包含行驶行为和修复行为的动态修复行为进行建模,采用滚动时域优化方法决策修复的先后顺序,得到抢修队最优动态修复方案。最后,设计多组算例以验证所提方法的可行性,结果表明,该方法可有效支撑灾后城市电力系统快速恢复,提高系统弹性。展开更多
基金Supported by the Key Specialty Construction Project of Shanghai Pudong New Area Health Commission,No.PWZzk2022-17Shanghai East Hospital Clinical Research Project,No.DFLC2022019and the Featured Clinical Discipline Project of Shanghai Pudong District,No.PWYts2021-06.
文摘BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface barrier.Notably,these enzymes play a significant role in the development of diverse tumors.AIM To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression Omnibus.The study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and PLA2G12B.Gene Set Enrichment Analysis was utilized to pinpoint associated pathways.Moreover,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was evaluated.RESULTS PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy individuals.Elevated expression of PLA2G2A was correlated with poorer overall survival in CCA patients.Additionally,the study delineated pathways and miRNAs associated with these genes.CONCLUSION Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for CCA.The increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.
文摘随着新型电力系统建设和“双碳目标”的发展,分布式新能源和灵活性负荷在配电网中的渗透率越来越高,主动配电网的低碳经济调度面临巨大挑战。考虑系统碳排放的同时考虑车辆到电站(vehicle-to-grid,V2G)的储能特性,建立了电动汽车有序充放电模型。基于可转移负荷和可中断负荷进行负荷需求响应建模,并对配电网支路潮流约束进行二阶锥松弛处理,以主动配电网调度成本最小为目标构建了一种考虑V2G储能特性与负荷需求响应的主动配电网日前低碳经济调度模型;计及风光出力不确定性得到主动配电网低碳鲁棒调度模型并采用行列生成算法(column and constraint generation,CCG)算法进行求解,以保证最坏场景的碳排放在允许范围以内。采用IEEE 33节点配电系统算例进行了验证,结果表明,所提模型能够有效降低主动配电网的调度成本和碳排放量。
文摘快速可行的灾后恢复是弹性电力系统的重要一环。提出一种弹性导向的考虑修复不确定性和V2G(vehicle to grid,V2G)的城市电力系统动态供电恢复方法,灾后短期内应用V2G站中的有限电动汽车资源为城市电网提供电能支撑,同时派遣抢修队对故障线路进行抢修作业,实现系统快速恢复。对V2G和电动汽车灾前、灾后行为进行建模,通过灾前自由调度统计各V2G站附近的电动汽车数量,按照响应意愿比例得到灾后阶段各V2G站反向输电功率;对包含行驶行为和修复行为的动态修复行为进行建模,采用滚动时域优化方法决策修复的先后顺序,得到抢修队最优动态修复方案。最后,设计多组算例以验证所提方法的可行性,结果表明,该方法可有效支撑灾后城市电力系统快速恢复,提高系统弹性。
