Poly(ADP-ribose)(PAR),a polymer of ADP-ribose,is synthesized by PAR po-lymerase and is crucial for the survival of cancer cells due to its vital functions in DNA repair and post-translational modifications.Beyond its ...Poly(ADP-ribose)(PAR),a polymer of ADP-ribose,is synthesized by PAR po-lymerase and is crucial for the survival of cancer cells due to its vital functions in DNA repair and post-translational modifications.Beyond its supportive role,PAR also triggers cancer cell death by excessive accumulation of PAR leading to an energy crisis and parthanatos.This phenomenon underscores the potential of targeting PAR regulation as a novel anticancer strategy,and the rationale would present an engaging topic in the field of anticancer research.Therefore,this editorial provides an overview of the mechanisms determining cancer cell fate,emphasizing the central role of PAR.It further introduces promising methods for modulating PAR concentrations that may pave the way for innovative anticancer therapies.展开更多
ADP晶体{100}面族生长的实时与非实时AFM(atomic force microscopy,AFM)研究表明,过饱和度σ处于0.005~0.04,生长温度介于293~313K之间时,晶面上观察到位错生长丘和其它晶体缺陷所形成的生长丘,晶面主要为台阶推进方式生长...ADP晶体{100}面族生长的实时与非实时AFM(atomic force microscopy,AFM)研究表明,过饱和度σ处于0.005~0.04,生长温度介于293~313K之间时,晶面上观察到位错生长丘和其它晶体缺陷所形成的生长丘,晶面主要为台阶推进方式生长;位错生长丘上空洞的出现与位错弹性理论相符;随过饱和度口降低,台阶形貌会发生相应变化;生长温度为298K时,台阶棱边能不小于6.2×10^-7/cm^2。展开更多
文摘Poly(ADP-ribose)(PAR),a polymer of ADP-ribose,is synthesized by PAR po-lymerase and is crucial for the survival of cancer cells due to its vital functions in DNA repair and post-translational modifications.Beyond its supportive role,PAR also triggers cancer cell death by excessive accumulation of PAR leading to an energy crisis and parthanatos.This phenomenon underscores the potential of targeting PAR regulation as a novel anticancer strategy,and the rationale would present an engaging topic in the field of anticancer research.Therefore,this editorial provides an overview of the mechanisms determining cancer cell fate,emphasizing the central role of PAR.It further introduces promising methods for modulating PAR concentrations that may pave the way for innovative anticancer therapies.
文摘ADP晶体{100}面族生长的实时与非实时AFM(atomic force microscopy,AFM)研究表明,过饱和度σ处于0.005~0.04,生长温度介于293~313K之间时,晶面上观察到位错生长丘和其它晶体缺陷所形成的生长丘,晶面主要为台阶推进方式生长;位错生长丘上空洞的出现与位错弹性理论相符;随过饱和度口降低,台阶形貌会发生相应变化;生长温度为298K时,台阶棱边能不小于6.2×10^-7/cm^2。