Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in ...Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in neuroinflammation in the cerebrum.However,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain unknown.In our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion injury.For in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller cells.We found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion injury.Furthermore,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte rleukin-18.The opposite results we re observed with Homerla ove rexpression.Finally,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion injury.Taken together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury.展开更多
Renewable energy is increasingly in demand for a variety of applications in both urban and rural areas. There are, however, a number of implementation constraints in some countries, even though sunshine, wind and wate...Renewable energy is increasingly in demand for a variety of applications in both urban and rural areas. There are, however, a number of implementation constraints in some countries, even though sunshine, wind and water are abundant and available. As part of this research, we are carrying out a technical and economic study on the availability of renewable energy in Cameroon, with a view to combining several sources of solar, biomass, wind and hydroelectric power to meet energy demand both inside and outside the country, in countries such as Chad, Gabon and Nigeria. In this work, the implementation of the entire system in the HOMER software demonstrates the feasibility and possibility of implementing a multi-source power plant based on renewable energies. Calculation of the levelized cost of energy (LCOE) and the net present cost (NPC) shows that a capacity of 485 GW can meet the energy demand of the countries bordering Cameroon. Furthermore, the calculation of the performance ratio gives a PR = 46.52 and a Capacity factor of CF = 11.64. The system is profitable not only economically but also environmentally, as it reduces greenhouse gas emissions and energy losses.展开更多
1.引言 NOW(Network of Workstations)系统是以商用工作站或高档微机作为处理节点,通过高速商用网或专用网络互联而构成的一种并行计算机系统,一般称之为并行机群系统。它具有可扩展性好、性能价格比高、用户投资风险小及软件资源丰富...1.引言 NOW(Network of Workstations)系统是以商用工作站或高档微机作为处理节点,通过高速商用网或专用网络互联而构成的一种并行计算机系统,一般称之为并行机群系统。它具有可扩展性好、性能价格比高、用户投资风险小及软件资源丰富等优点。展开更多
基金supported by the Youth Development Project of Air Force Military Medical University,No.21 QNPY072Key Project of Shaanxi Provincial Natural Science Basic Research Program,No.2023-JC-ZD-48(both to FF)。
文摘Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in neuroinflammation in the cerebrum.However,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain unknown.In our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion injury.For in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller cells.We found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion injury.Furthermore,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte rleukin-18.The opposite results we re observed with Homerla ove rexpression.Finally,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion injury.Taken together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury.
文摘Renewable energy is increasingly in demand for a variety of applications in both urban and rural areas. There are, however, a number of implementation constraints in some countries, even though sunshine, wind and water are abundant and available. As part of this research, we are carrying out a technical and economic study on the availability of renewable energy in Cameroon, with a view to combining several sources of solar, biomass, wind and hydroelectric power to meet energy demand both inside and outside the country, in countries such as Chad, Gabon and Nigeria. In this work, the implementation of the entire system in the HOMER software demonstrates the feasibility and possibility of implementing a multi-source power plant based on renewable energies. Calculation of the levelized cost of energy (LCOE) and the net present cost (NPC) shows that a capacity of 485 GW can meet the energy demand of the countries bordering Cameroon. Furthermore, the calculation of the performance ratio gives a PR = 46.52 and a Capacity factor of CF = 11.64. The system is profitable not only economically but also environmentally, as it reduces greenhouse gas emissions and energy losses.
