Carbon Isotope Excursions and Paleo-Oceanography of the Ordovician–Silurian Boundary Carbonate Rocks from the Xainza Area, Tibet

Objective The Ordovician–Silurian transitional period is a special time when the global paleo-environment changed greatly.It witnessed the first mass extinction as of Phanerozoic period and glaciations that occurred frequently at a large scale in a very short time,which has thus attracted much attention among geoscientists at home and abroad.

Analysis on blood glucose excursions in well-controlled patients with type 2 diabetes mellitus

Objective:To probe glycemic excursions in type 2 diabetic patients whose hemoglobin A1c(HbA1c) was kept ≤6.0%.Methods:Totally 36 cases with type 2 diabetes(T2DM) with HbA1c≤6.0% and 30 cases with normal glucose tolerance(NGT) from December 2005 to December 2007 in our department were subjected prospectively.Continuous glucose monitoring system(CGMS) was employed to record their continuous blood glucose level for 3 d.The blood glucose profiles including the mean blood glucose(MBG),standard differentiation(SD),mean amplitude of glycemic excursions(MAGE) and absolute means of daily differences(MODD) were analyzed.Results:T2DM group had obviously postprandial hyperglycemia,in about 2 h after meal,especially after breakfast.Fifty-two hypoglycemic episodes occurred during the monitoring period in T2DM groups,of which 73.1%(38 episodes) were absence of symptomatic hypoglycemia with the lowest value of blood glucose only 2.0 mmol/L.And 20 episodes took place during the day hours,while 32 episodes observed during the night hours.Compared with NGT groups,SD,MAGE and MODD were all significantly higher in T2DM groups.MBG was significantly correlated with HbA1c in T2DM groups,but SD,MAGE,NGE and MODD were all independent of HbA1c.MAGE was independent of MODD.Conclusion:The amplitude of glycemic excursions is higher in normol-controlled T2DM groups than the NGT groups.Thus ideally glycemic control is not only to make HbA1c reach standard,but also to lessen glycemic excursions and reduce hypoglycemia episodes.

Excursions to 60 and 80 MSW with Heliox from Saturation at 25 MSW

Vertical excursions allow divers in seafloor habitats to work at depths deeper than thehabitat.Descending excursions from saturation in nitrox have almost all used air as the breathing gas;depth is effectively restricted to less than 60 msw by narcosis and oxygenexposure.The objective is to investigate use of helium mixtures for excursions, taking

Paleomagnetic Excursions Recorded in the Yanchi Playa in Middle Hexi Corridor, NW China Since the Last Interglacial

Paleomagnetic determinations on lithological profiles of two paralleled[( )-275(long )]drilling cores covering the past 130 kyr B.P., GT40 and GT60, from the Yanchi Playa in the arid Northwestern China, indicate that a series of pronounced paleomagnetic excursions have been documented. By correlating our results with published regional and worldwide reports, 4 excursion events out of 10 apparent reversal signals (labeled from GT-1 to GT-10) were identified as excursion events coeval with the Mono Lake Event ([(28.4)( )]kyr~[(25.8)( )]kyr), Laschamp Event ([(43.3)( )]kyr^40.5 kyr), Gaotai Event (82.8 kyr~[(72.4)25( )]kyr) and the Blake Event (127.4 kyr^113.3 kyr), respectively. GT-9 correlates with the above-mentioned Gaotai Event, GT-7 and GT-6 correspond to two stages of the Laschamp Event and GT-5 to the Mono Lake Event. It is noteworthy that the so-called Gaotai Event has not been reported as a pronounced paleomagnetic excursion in the Northwestern China. Every magnetic excursion event corresponds to paleointensity minima, anteceding those established abrupt paleoclimatic change events, such as the Younger Drays and the Heinrich Events (H1-H6)[(. )-250( )]Here,[( )-250( )]we tentatively[( )-250( )]propose that these geomagnetic excursions/reversals can be viewed as precursors to climate abruptness. During the transitional stages when the earths magnetic field shifted between a temporal normal and a negative period, the earths magnetic paleointensity fell correspondingly to a pair of minima. Although more precise chronology and more convincing rock magnetic parameter determinations are essentially required for further interpretation of their intricate coupling mechanism, these results may have revealed, to some extent, that the earths incessantly changing magnetic field exerts an strong influence on the onset of saw-tooth shaped abrupt climate oscillations through certain feedback chains in arid Central Asia or even North Hemispheric high latitude regions.

On the Possibility of Obtaining Geomagnetic Volcanic Records of the Short-Term Behavior of the Laschamp and Pringle Falls Excursions from the Long Sequence of Kahuku and Ninole Hills, Big Island of Hawaii, USA

The Mauna Loa volcano of the Big Island of Hawaii offers the “ad-hoc” lava flows that have recorded the geomagnetic short-term behavior (i.e. excursions) at two key localities such as the younger Kahuku volcanic series (ca. ~41 ka) where 29 flows are exposed for detailed paleomagnetic sampling making up 102 meters of section where the uppermost flow sampled lies directly under the Pahala ash. The second sampling site is the Ninole volcanic series where 25 flows spanning 56 meters of section were also sampled from the northeast and southwest sides of the Kilohana Ridge. The most recent age estimate indicates that the Kahuku flows can correlate well with the transitional/excursional directional results obtained from both volcanic and deep-sea sediments of the global record of the Laschamp (ca. ~41 ka calendar years B.P) excursion and the Ninole flows which are associated to the also global Pringle Fall excursion (ca. 211 ± 13 ka) recorded at the type section.

Significant carbon isotope excursions in the Cambrian and their implications for global correlations

The existing δ 13C data in the Cambrian from different regions of the world are analyzed here. There are four well-documented carbon isotope excursions with global significance. In ascending order, they are： （1） a large negative excursion, comparable to ＂BACE＂ （BAsal Cambrian Carbon isotope Excursion） event, which occurs near the Precambrian-Cambrian boundary with a magnitude of 4‰-10‰ （PDB）; （2） the ＂ZHUCE＂ （ZHUjiaqing Carbon isotope Excursion） event, a distinct positive excursion （over 5%0） that can be recognized at the Fortunian Stage to Stage 2 transition; （3） another strong negative one, so-called ＂ROECE＂ （Redlichiid-Olenellid Extinction Carbon isotope Excursion） event, shifting at the interval between Series 2 and Series 3, peaking at -3‰--5‰ （PDB）; （4） the famous Steptoean positive carbon isotope excursion （SPICE）, which has been widely identified at the base of Furongian Series, Paibian Stage, with an amplitude about 4‰ （PDB）. The four sharp σ13C shifts correlate well with coeval paleoceanographic changes and bioevents. Besides, there are some σ13C excursions from a few sections in previous studies, and more data are required to identify whether they are global or regional ones.

Correlation between 1,5-anhydroglucitol and glycemic excursions in type 2 diabetic patients

Background The accurate and comprehensive assessment of glycemic control in patients with diabetes is important for optimizing glycemic management and for formulating personalized diabetic treatment schemes. This study aimed to analyze the correlation between 1,5-anhydroglucitol （1,5-AG） and glycemic excursions in type 2 diabetic patients. Methods Seventy-one outpatients with type 2 diabetes mellitus were randomly recruited from Chinese People＇s Liberation Army General Hospital. Using a continuous glucose monitoring system （CGMS）, these patients＇ blood glucose levels were monitored for three consecutive days to obtain mean blood glucose （MBG） data. Intraday glycemic excursions were evaluated using the mean amplitude of glycemic excursions （MAGE）, the largest amplitude of glycemic excursions （LAGE）, standard deviation of blood glucose （SDBG） and the M-value. Interday glycemic excursion was assessed by absolute mean of daily difference （MODD）. Postprandial glycemic fluctuations were evaluated using postprandial glucose excursions （PPGE） and postprandial incremental area under the curve （iAUC）. Fasting venous blood samples were collected to measure serum 1,5-AG, whole-blood hemoglobin Alc （HbAlc） and serum glycated albumin （GA）. Clinical markers of glycemia and parameters of glycemic excursions from CGMS were analyzed using the Pearson correlation coefficient and multivariate stepwise regression. Results Pearson correlation analysis revealed that 1,5-AG was significantly correlated with MAGE, SDBG, M-value, LAGE, PPGE and iAUC （r values were-0.509,-0.430,-0.530,-0.462,-0.416 and-0.435, respectively, P 〈0.01）, especially in moderately and well-controlled patients, based on defined HbAlc levels. Multivariate stepwise regression analysis revealed a negative correlation between 1,5-AG and the above parameters, but not HbAlc and GA. Finally, HbAlc and GA were positively correlated with MBG and fasting blood glucose （FBG）. Conclusions 1,5-AG was much better than HbAlc and GA as a marker of glycemic excursions in type 2 diabetic patients. Based on these results 1,5-AG is the best metric for assessing postprandial glucose levels in moderately and well-controlled patients, while HbAlc and GA were superior to 1,5-AG for monitoring MBG and FBG.

The largest negative carbon isotope excursions in Neoproterozoic carbonates caused by recycled carbonatite volcanic ash

The late Ediacaran Shuram Excursion(SE)records the most prominent negativeδ^(13)C excursions(δ^(13)C=-12‰)during Earth’s history.It has been hypothesized to have resulted from oxidation of dissolved organic matter,diagenetic or authigenic precipitates.However,the origin of the SE remains enigmatic;current models face challenges regarding the significant amount of atmospheric oxygen needed to balance such extensive oxidation and sustained inputs of light carbon with extremely negative C isotope compositions.Here,we show that the Doushantuo Formation at the Jiulongwan section in South China,a key stratum recording the SE event,contains mineralogical and geochemical signatures related to igneous processes.Both the occurrence of ankerite,feldspar,moissanite and euhedral quartz in the SE samples and the relatively consistent Ce anomalies of carbonate and O isotopes of quartz indicate a contribution from an igneous source.In particular,the SE samples have trace element and C isotope compositions similar to those of recycled carbonatites formed by decarbonation and melting of sedimentary carbonate rocks.These observations suggest that the deep cycle of ancient carbonate rocks,which were subjected to decarbonation during subduction,melting and eruption related to the breakup of the Rodinia supercontinent,contributed to the SE.This igneous model for the SE may provide a connection between the deep and shallow carbon cycles of the Earth.

EXCURSIONS AND LVY SYSTEM OF BOUNDARY PROCESS

In this paper, the authors investigate the joint distribution of end points of excursion awayfrom a closed set straddling on a fixed time and use this result to compute the Levy systemand the Dirichlet form of the boundary process.

Characteristics of blood glucose excursions in type 2 diabetes mellitus patients with three different Traditional Chinese Medicine syndromes

OBJECTIVE:To explore the characteristics of blood glucose excursions of type 2 diabetes mellitus patients with three different Traditional Chinese Medicine(TCM) syndromes.METHODS:One hundred and nine patients with type 2 diabetes mellitus were recruited from the Department of Endocrinology and the Department of TCM of the Sixth People's Hospital affiliated to Shanghai Jiao Tong University.Subjects were divided into three groups according to TCM syndrome:intrinsic Damp(n- 42),Yin deficiency and internal Heat(n = 25),and Qi and Yin deficiency(n- 42).Subcutaneous interstitial glucose was monitored with a continuous glucose monitoring system for 3consecutive days to investigate the glycemic profile in each group.Plasma C-peptide levels were measured,and an arginine test was taken in 10 patients randomly selected from each group.Glucose data and glycemic variability were analyzed to investigate the differences among the groups.The change in C-peptide levels and the results from arginine trial were used to evaluate β cell function.RESULTS:Indicators reflecting blood glucose level were the highest in subjects with Yin deficiency and internal Heat syndrome,and parameters reflecting glycemic variability were the lowest in those with Qi and Yin deficiency syndrome.The change in C-peptide levels showed that subjects with Qi and Yin deficiency syndrome had the best βcell function among the three groups;this was confirmed by the arginine trial.CONCLUSION:Patients with Qi and Yin deficiency syndrome had a more stable blood glucose profile,as glycemic variability was higher in those with intrinsic Damp syndrome and those with Yin deficiency and internal Heat syndrome.

Carbon-Isotope Excursions Recorded in the Cambrian System,South China:Implications for Mass Extinctions and Sea-Level Fluctuations

Cambrian carbonates with abundant fossils of agnostoid trilobites deposited on the southern slope （Jiangnan slope belt） of the Yangtze Platform and in the Jiangnan deepwater basin are well exposed in the Wangeun Section of western Hunan, South China, and in the Duibian A Section of western Zhejiang, southeastern China, respectively. To better understand the response of carbonisotope excursions to depositional environment changes, mass extinctions and eustatic events, we collected 530 carbonate samples in fresh roadcut exposures of the two measured sections for analysis of carbon and oxygen isotopic compositions. Data of δ^13C from the Wangcun Section, western Hunan, South China, demonstrate that the Cambrian carbon-isotope profile includes three remarkable positive excursions CPEwc-1, 2, 3 in the Upper Series 2, in the Lower and in the Middle Furongian Series. Three distinctive negative excursions CNEwc,-1, 2, 3 were separately tested in the Lower Terreneuvian Series, Lower Series 3 and in the Upper Furongian Series. Similarly, in the corresponding horizons in the Duibian A Section, Zhejiang Province, southeastern China, three positive excursions CPEdb-1, 2, 3 and three negative excursions CNEdb-1, 2, 3 also have been discovered. We interpret these significant carbon-isotope excursions as being associated with enhanced biogenic prodnctivity, mass extinctions and eustatic events.

A record of Miocene carbon excursions in the South China Sea

High-resolution δ13C records are presented for the Miocene benthic foraminifers Cibici doides wuellerstorfi and C. kullenbergi (24-5 Ma) and the planktonic foraminifer Globigerinoides sacculifer (18-5 Ma) from ODP Site 1148A (18° 50.17′N, 116° 33.93′E, water depth 3308.3 m),northern South China Sea. The general pattern of parallel benthic and planktonic δ13C shows a decrease trend of δ13C values from the early-middle Miocene to the middle-late Miocene. Two dis tinct δ13C positive excursions at 23.1-22.2 and 17.3-13.6 Ma, and two negative excursions at 10.2-9.4 and 6.9-6.2 Ma have been recognized. All these events are cosmopolitan, providing the good data for the stratigraphic correlation of the South China Sea with the global oceans as well as for studying the changes of the global carbon reservoir and its corresponding climate.

Carbon isotopic record from Upper Devonian carbonates at Dongcun in Guilin, southern China, supporting the world- wide pattern of carbon isotope excursions during Frasnian-Famennian transition

Two positive d 13C excursions are presented in records from the Frasnian-Famennian (F-F) marine carbon-ate sediments in Europe, America, Africa, and Australia, having been considered as a worldwide pattern, and attrib-uted to enhanced organic carbon burial during the F-F biological mass extinction. However, this worldwide pattern has not been revealed from the well-deposited Late Devonian sequences in southern China. In this paper, a detailed inves-tigation has been made on the Late Devonian section at Dongcun, Guilin, southern China to constrain perturbations in d 13C of carbonates in the F-F deposited sequence. The result from this section also indicates two positive d 13C ex-cursions during the F-F transition. The first excursion with an amplitude of 1.5 occurred at the bottom of linguiformis Zone, later than the early excursion existing in the Late rhe-nana Zone of the Late Devonian profiles in other continents, especially, in central Europe. This difference has been ex-pected to be a result as conodont Palmatolepis linguiformis occurred earlier in southern China than other sites. The second excursion with an amplitude of 2.1 is located at the F-F boundary, same as the records from other continents. This result strongly supports the view that two carbon iso-tope positive excursions during the F-F transition are com-mon in carbonate sediments, resulting from worldwide in-creases of organic carbon burial intensity.

The impact of round window vs cochleostomy surgical approaches on interscalar excursions in the cochlea:Preliminary results from a flat-panel computed tomography study

Objective:To evaluate incidence of interscalar excursions between round window (RW) and cochleostomy approaches for cochlear implant (CI) insertion. Methods:This was a retrospective case-comparison. Flat-panel CT (FPCT) scans for 8 CI users with Med-El standard length electrode arrays were collected. Surgical technique was identified by a combination of operative notes and FPCT imaging. Four cochleae underwent round win-dow insertion and 4 cochleae underwent cochleostomy approaches anterior and inferior to the round window. Results:In our pilot study, cochleostomy approaches were associated with a higher likeli-hood of interscalar excursion. Within the cochleostomy group, we found 29% of electrode contacts (14 of 48 electrodes) to be outside the scala tympani. On the other hand, 8.5%of the electrode contacts (4 of 47 electrodes) in the round window insertion group were extra-scalar to the scala tympani. These displacements occurred at a mean angle of occur-rence of 364? ? 133?, near the apex of the cochlea. Round window electrode displacements tend to localize at angle of occurrences of 400? or greater. Cochleostomy electrodes occurred at an angle of occurrence of 19?e490?.

Prognostic Role of Preoperative Tricuspid Annular Plane Systolic Excursion (TAPSE) in Mitral Valve Replacement (MVR) for Rheumatic Mitral Stenosis Patients

Tricuspid annular plane systolic excursion has been proposed as a simple and reproducible parameter for quantitative assessment of the right ventricular ejection fraction. The prognostic importance of preoperative TAPSE in patients with mitral valve replacement for rheumatic mitral stenosis patients is still under focused. Therefore, the objective of the study was to predict the outcome after MVR in rheumatic mitral stenosis patients in relation to preoperative TAPSE. This comparative cross-sectional study was conducted at the Department of Cardiac Surgery, National Heart Foundation Hospital and Research Institute. A total of 72 patients of rheumatic mitral stenosis patients who underwent mitral valve replacement were included in the study. They were divided into two groups: Group A and B. Group A included 36 patients with TAPSE 0.05) except for the preoperative TAPSE. Mean TAPSE of Group A was 13.17 (±1.40) and Group B was 18.61 (±1.57), the difference was statistically significant (p 0.05). Among the postoperative complications, including postoperative atrial fibrillation was higher in Group A (30.56%) than Group B (11.11%), mean ventilation time was higher in Group A (27.78%) than Group B (5.56%), length of intensive care was higher in Group A (33.33%) than Group B (11.12%), and hospital stay was higher in Group A (25.0%) than Group B (5.56%), (p < 0.05). Higher preoperative TASPE could be used as a prognostic tool for MVR in rheumatic mitral stenosis patients in our settings.

Review on Dating Methods:Numerical Dating in the Quaternary Geology of High Asia

Over the past few years, OSL and TCN datings of glacial material from High Asia have come into fashion. To this day, however, these techniques do not permit safe calibration. The intensity of the cosmic ray flux is being modulated by the solar and terrestrial magnetic fields and their secular fluctuations in the past. So far, these variations cannot be converted into the respective local TCN production rates for High Asia. We have reason to believe that the ages that are being calculated despite these uneertainties are generally overestimated. This assessment is supported by eonventional radiocarbon dates and above＂ all by the glacial chronology developed independently on the basis of the Quaternary geological method. The strongly emerging evidence for a much more extensive LGM glaciation of High Asia is, however, either being ignored or rejected by many authors, solely on the basis of the above-mentioned uncalibrated datings. This self-conceit based on the ＂dating fallacy＂, as we call it, should be avoided since it goes decidedly against the standards of the scientific method established in Quaternary geology and makes a fundamental scientific discussion impossible.

Paleoceanographic records in the Chukchi Basin, western Arctic Ocean during the late Quaternary

The late Quaternary paleoceanographic changes in the western Arctic Ocean are revealed by quan- titative studies of foraminiferal abundance, ice-rafted detritus （IRD） and its mineralogical and petrological compositions, planktonic Neogloboquadrina pachyderma （sin.） （Nps）-δ18O and -δ13C, biogenic and non-biogenic components in Core M03 token from the Chukchi Basin during the Sec- ond Chinese National Arctic Expedition cruise. Seven IRD events appeared at MIS 7, 5, 3 and 1. These IRD were carried in massive icebergs, which were exported to the Beaufort Sea through the M＇Clure Strait Ice Stream, Canadian Arctic Archipelago, and then transported into the Chukchi Basin by the Beaufort Gyre. Low IRD deposition occurred during the glacial times when more extended ice cover and weakened Beaufort Gyre, while the open water condition and the intensified Beaufort Gyre during interglacial periods favored the IRD deposition. Therefore, the IRD events not only indicate the provenance of coarser detritus and ice export events, but also reflect the evolutionary histories of the Beaufort Gyre and North American ice sheet. Seven light Nps-δ18O and -δ13C excursions could respond to enhanced rates of sea ice formation resulting in the pro- duction and sinking of isotopically light brines, but was irrelevant to the warm Atlantic water and freshwater inputs. Whereas, the heavy Nps-δ18O and -δ13C values separately reflect the lessened Arctic freshwater and Pacific water, and well-ventilated surface water from the continental shelf and halocline water. Variations of CaCO3 content and planktonic foraminiferal abundance during the interglacial and glacial periods can demonstrate the incremental or diminishing input of the Atlantic water, while the total organic carbon （TOC） and opal contents increased and decreased during the glacial and interglacial periods, respectively, which could be related to the TOC degradation, opal dissolution and redox conditions of interface between the bottom water and sediments.

非时齐跳跃Markov过程序列到扩散过程的弱收敛

本文给出了非时齐跳跃Markov过程序列弱收敛于非时齐扩散过程的一般性定理。利用这一定理,证明了非负非时齐跳跃Markov过程序列弱收敛于Brownian Excursion和经验分布过程弱收敛于Bown桥。

The Two Faces of Urbanity： Exploring Global and Local Values---Two Urban Studios in Taksim Square and along the Shores of the Golden Horn in Istanbul

Since the 18th century, the irritating but also fascinating scenes of urbanity--a complex phenomenon with cultural, social, political, economic, temporal, spatial, functional, and formal dimensions--have been described in literary works. Many seemingly opposite facts, such as individuality/society, freedom/loneliness/socialization, anonymity/strangeness/identity/belonging, diversity/chaos/segregation, indifferent city-dweller/initiative citizenship, have been revealed through literary works, travel and utopian writing, urban theories, scientific studies, manifestos, and newspaper articles. On the one hand, there are those who advocate a life outside the city because they consider the problems produced by the city and the phenomenon of density which they perceive merely in quantitative terms, as unsolvable problems. On the other hand, there are those who see the production of loose urban fabric as a solution or those who accept the （seemingly） opposite facts of urbanity as positive values and therefore support city life. All of these ideas are still as actual today as they were in the past. We are often unable to use our citizen rights to the city, to encounter different classes （social/etlmic/religious）, to experience heterogeneity as an aspect inherent in city life and in the route of our daily life--following the orders of the capitalist system mainly organized around work--and we are often drawn into the same districts on the same paths. Our perception of our urban environments may get monotonous and shallow, but the irritating yet fascinating features of the first big cities still exist and may be grasped and brought into consciousness. Throughout their architectural education, especially in urban design studios, students can be encouraged to investigate the rhythm of their daily life, the conditions of their urban environments, and discovering the city as an intellectual and sensual programme, so that the phenomenon of urbanity can be grasped not just on formal, but on various other dimensions as well. This study focuses on the process and outcomes of two urban studios located in Taksim Square and along the shores of the Golden Horn in Istanhul. Taking the multidimensional content of urbanity into account, acquired theoretically through literary works and studies on urban planning and its history, the main aim of these studios has been the phenomenological understanding of the dynamic content of urbanity by the students. Through creative analysis of permanent/temporary spaces engendered by the diversity of user profiles and actions discovered on phenomenological excursions, students examine the qualitative values of density and global and local dynamics. We believe that designing spaces as ＂prototypes＂ helps highlight the multidimensional content of urbanity. The present study aims not only to highlight the multidimensional content of urbanity, but also to encourage its discussion in architectural design education and to emphasize the positive contribution of theoretical readings and phenomenological studies to urban design studios. The present study also aims to emphasize the beneficial correlation of global and local dynamics as the two faces of urbanity; important more than ever for the big cities of the 21 st century if we advocate for a vivid and resilient city life and citizens.

Analysis of the characteristics of diabetic peripheral nerve damage by high frequency ultrasound combined with QTT

Objective: High frequency ultrasound combined with policy thermal perception testing (QTT) was used to analyze the characteristics of nerve damage in diabetic peripheral neuropathy (DPN), and then provided the basis for the clinical prevention, diagnosis and treatment of DPN. Methods: A total of 110 DPN patients admitted to the hospital from December 2015 to May 2018 were selected, and the characteristics of nerve damage in diabetic peripheral neuropathy were analyzed by ultrasound and QTT. Results: In the results of QTT, the abnormal proportion of the CDT, WDT, CPT and HPT of the lower limbs in DPN's were all higher than the upper limbs;The difference of WDT and HPT in the age and course groups of patients in the upper limbs was statistically significant, the abnormal proportion of WDT and HPT in patients aged 60 years or above or with a course of 10 years or more were all above 45%, higher than those in other groups. The patients with larger mean amplitude of glycemic excursions (MAGE) were significantly higher than those with smaller MAGE, regardless of the abnormal proportion of WDT and HPT observed in upper limbs, lower limbs or upper and lower limbs;The results of ultrasonic measurement of nerve cross sectional area showed: the proportion of patients with ulnar nerve and median nerve abnormally thickened in the high age group (≥45 years) and the long course group (>10 years) was significantly higher than that in the low age group (<45 years) and the short course group (<10 years), the proportion of patients with larger MAGE with abnormal enlargement of median nerve was significantly higher than those with smaller MAGE. The thickening of ulnar nerve, median nerve and peroneal nerve was obvious in the patients of MAGE > 4 mmol/L. Conclusion: (1) The main nerve damage in DPN patients was thermal sensation damage, and the lower limb nerve was more vulnerable than the upper limb nerve. (2) The incidence of ulnar and median nerve damage was higher in patients aged 45 years and older or over 10 years of course. (3) Patients with large MAGE (> 4 mmo/L) had higher incidence of median nerve damage. The above characteristics of nerve damage can provide basis for clinical prevention, diagnosis and treatment of DPN.