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In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease 被引量:1
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作者 Li-Ping Yu Yan-Juan Li +5 位作者 Tao Wang Yu-Xuan Tao Mei Zhang Wen Gu Jie Yu Xing-Xin Yang 《World Journal of Gastroenterology》 SCIE CAS 2023年第1期171-189,共19页
BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic i... BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic ingredients for mitigating MAFLD remain unclear.AIM To research the active ingredients of PM adjusting mitochondria to relieve highfat diet(HFD)-induced MAFLD in rats.METHODS Fat emulsion-induced L02 adipocyte model and HFD-induced MAFLD rat model were used to investigate the anti-MAFLD ability of PM and explore their action mechanisms.The adipocyte model was also applied to evaluate the activities of PM-derived constituents in liver mitochondria from HFD-fed rats(mitochondrial pharmacology).PM-derived constituents in liver mitochondria were confirmed by ultra-high-performance liquid chromatography/mass spectrometry(mitochondrial pharmacochemistry).The abilities of PM-derived monomer and monomer groups were evaluated by the adipocyte model and MAFLD mouse model,respectively.RESULTS PM repaired mitochondrial ultrastructure and prevented oxidative stress and energy production disorder of liver mitochondria to mitigate fat emulsion-induced cellular steatosis and HFD-induced MAFLD.PM-derived constituents that entered the liver mitochondria inhibited oxidative stress damage and improved energy production against cellular steatosis.Eight chemicals were found in the liver mitochondria of PM-administrated rats.The anti-steatosis ability of one monomer and the anti-MAFLD activity of the monomer group were validated.CONCLUSION PM restored mitochondrial structure and function and alleviated MAFLD,which may be associated with the remedy of oxidative stress and energy production.The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD.Thus,PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction.Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases. 展开更多
关键词 Fatty liver MITOCHONDRIA Pharmacodynamic ingredients Polygonum multiflorum
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Variation and Cluster Analysis on Leaf Characters from Different Provenance Sources of Polygonum multiflorum Thunb 被引量:2
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作者 韦艳梅 王凌晖 +2 位作者 曹福亮 韦山青 梁耀丹 《Agricultural Science & Technology》 CAS 2010年第6期94-98,共5页
[Objective] The aim was to study the variation of leaf characters from different provenance sources of Polygonum multiflorum Thunb,as well as to carry out cluster analysis on P.multiflorum from different provenance so... [Objective] The aim was to study the variation of leaf characters from different provenance sources of Polygonum multiflorum Thunb,as well as to carry out cluster analysis on P.multiflorum from different provenance sources to provide basis for the classification,identification,breeding and improved variety selection of P.multiflorum.[Method] Leaf shape characters of 31 copies of germplasm resources in the major distribution region of the whole country were determined,and the genetic variation of P.multiflorum leaves from different producing areas was analyzed.[Result] The leaf characters of single plant of the same experimental provenance source of P.multiflorum were relatively stable,the variation was mainly found on the single leaf area,1/2 leaf width,leaf width and other indicators;the variation of each leaf character among different provenance sources was obvious,and the variation was mainly found on the single leaf weight,leaf area,1/2 leaf width,leaf length and other indicators.The correlation analysis of each leaf character in P.multiflorum suggested that the single leaf area and single leaf weight showed extremely significant positive correlation with leaf length,1/2 leaf width,leaf width,leaf thickness and leaf stem length,while the single leaf area and single leaf weight showed significant negative correlation with WWR(leaf width/1/2 leaf width)and LWR(leaf length/1/2 leaf length),in addition,several macroscopic leaf characters such as leaf length,1/2 leaf width,leaf width,leaf stem length showed extremely positive correlation.The main component analysis result suggested that the contribution rate of accumulation variance of the front three main components was up to 97.4%,which could better reflect the comprehensive performance of leaf characters of different provenance sources of P.multiflorum.The cluster analysis showed that the experimental 31 copies of P.multiflorum provenance sources should be divided into three classes,the first class was distributed in the Middle,Western of Guizhou,northwestern of Guangxi and western areas with higher altitude;the second class was distributed in Hunan,Hubei,Sichuan,Guangdong and the most area of Guangxi;the third class was distributed in Anhui,Jiangsu and Henan and Shandong.[Conclusion] Cluster analysis of leaf characters indicated that the kinds of provenance sources which the geographical position was closer could be got together.The study had provided a certain basis for the classification of P.multiflorum. 展开更多
关键词 Polygonum multiflorum Thunb Leaf characters VARIATION Cluster analysis
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Novel Stilbene Glycosides from Polygonum multiflorum 被引量:11
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作者 肖凯 宣利江 +1 位作者 徐亚明 白东鲁 《Acta Botanica Sinica》 CSCD 2002年第12期1491-1494,共4页
Two new stilbene glycosides (1 and 2), together with nine known compounds (3-11), were isolated from the water extract of Polygonum multiflorum Thunb. The structures of the new compounds were elucidated by their c... Two new stilbene glycosides (1 and 2), together with nine known compounds (3-11), were isolated from the water extract of Polygonum multiflorum Thunb. The structures of the new compounds were elucidated by their chemical properties and spectroscopic analyses, including extensive 2D NMR experiments. Compound 2 showed strong DNA cleavage activity, and compounds 1, 2 and 10 (2, 3, 4′, 5_tetrahydroxy_ trans _stilbene_2_O_β_ D _glucopyranoside) exhibited significant inhibition of lipid peroxidation. 展开更多
关键词 Polygonum multiflorum stilbene glycoside DNA cleavage activity inhibition of lipid peroxidation
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Single-nucleotide polymorphisms of HLA and Polygonum multiflorum-induced liver injury in the Han Chinese population 被引量:11
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作者 Wan-Na Yang Li-Li Pang +8 位作者 Ji-Yuan Zhou Yuan-Wang Qiu Liang Miao Shou-Yun Wang Xiang-Zhong Liu Kang-An Tan Wan-Wan Shi Gui-Qiang Wang Feng-Qin Hou 《World Journal of Gastroenterology》 SCIE CAS 2020年第12期1329-1339,共11页
BACKGROUND Polygonum multiflorum is one of the leading causes of herb-induced liver injury in China.HLA-B*35:01 is reported to be a potential biomarker of Polygonum multiflorum-induced liver injury(PM-DILI).However,li... BACKGROUND Polygonum multiflorum is one of the leading causes of herb-induced liver injury in China.HLA-B*35:01 is reported to be a potential biomarker of Polygonum multiflorum-induced liver injury(PM-DILI).However,little is known about the relationship between single-nucleotide polymorphisms(SNPs) and PM-DILI.AIM To identify SNPs that indicate susceptibility to PM-DILI METHODS We conducted a systematic study enrolling 382 participants from four independent hospitals,including 73 PM-DILI patients,118 patients with other drug-induced liver injury(other-DILI) and 191 healthy controls.Whole-exome sequencing was performed for 8 PM-DILI patients and 8 healthy controls who were randomly selected from the above subjects.Nineteen SNPs that showed high frequencies in the 8 PM-DILI patients were selected as candidate SNPs and then screened in 65 PM-DILI patients,118 other-DILI patients and 183 healthy controls using the MassARRAY system.HLA-B high-resolution genotyping was performed for the 73 PM-DILI and 118 other-DILI patients.The Han-MHC database was selected as a population control for HLA-B analysis.P <6.25 x 103 after Bolferroni correction was considered significant.RESULTS The frequencies of rslll686806 in the HLA-A gene,rs1055348 in the HLA-B gene,and rs202047044 in the HLA-DRB1 gene were significantly higher in the PM-DILI group than in the control group [27.2% vs 11.6%,P=1.72×105,odds ratio(OR)=3.96,95% confidence interval(Cl):2.21-7.14;42.5% vs 8.6%,P=1.72×10-19 OR=13.62,95% CI:7.16-25.9;22.9% vs 8.1%,P=4.64×106,OR=4.1,95% CI:2.25-7.47].Only rs1055348 showed a significantly higher frequency in the PM-DILI group than in the other-DILI group(42.5% vs 13.6%,P=1.84×10-10,OR=10.06,95% Cl:5.06-20.0),which suggested that it is a specific risk factor for PM-DILI.rs1055348 may become a tag for HLA-B*35:01 with 100% sensitivity and 97.7% specificity in the PM-DILI group and 100% sensitivity and 98.1% specificity in the other-DILI group.Furthermore,HLA-B*35:01 was confirmed to be associated with PM-DILI with a frequency of 41.1% in the PM-DILI group compared with 11.9%(P=4.30×10-11,OR=11.11,95% CI:5.57-22.19) in the other-DILI group and 2.7%(P=6.22×10-166,OR=62.62,95% Cl:35.91-109.20) in the Han-MHC database.CONCLUSION rslll686806,rs1055348,and rs202047044 are associated with PM-DILI,of which,rs1055348 is specific to PM-DILI.As a tag for HLA-B*35:01,rs1055348 may become an alternative predictive biomarker of PM-DILI. 展开更多
关键词 Drug-induced liver injury Polygonum multiflorum Single-nucleotide polymorphism rs111686806 rs1055348 rs202047044 HLA-B*35
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Two new coumarin glucosides biosynthesized by transgenic hairy roots of Polygonum multiflorum 被引量:5
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作者 Rong Min Yu Liang Bin Zhou +2 位作者 Chun Yan Yan Guo Yan Duan Yu Zhao 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第1期76-78,共3页
The glycosylation of hydroxylcoumarin was investigated by using suspension cultures of hairy roots of Polygonum multiflorum. Two new coumarin glucosides (3 and 4) were biosysthesized by regioselectively glycosylatio... The glycosylation of hydroxylcoumarin was investigated by using suspension cultures of hairy roots of Polygonum multiflorum. Two new coumarin glucosides (3 and 4) were biosysthesized by regioselectively glycosylation of corresponding substrates (1 and 2) in the system. The structures of two products were identified as 7-hydroxy-4-methylcoumarin 5-O-β-D-glucopyranoside and 7- hydroxy-3,4-dimethylcoumarin 5-O-β-D-glucopyranoside on the ground of chemical and spectroscopic methods, respectively. 2007 Rong Min Yu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 展开更多
关键词 Polygonum multiflorum Hairy roots Glycosylation 7-Hydroxy-4-methylcoumarin 5-O-13-o-glucopyranoside 7-Hydroxy-3 4-dimethylcoumarin 5-O-β-D-glucopyranoside
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Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum:A case report 被引量:2
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作者 You-Lin Shao Chun-Ming Ma +2 位作者 Jian-Ming Wu Feng-Cai Guo Suo-Cai Zhang 《World Journal of Clinical Cases》 SCIE 2022年第27期9921-9928,共8页
BACKGROUND Various types of drug-induced liver injury are induced by Polygonum multiflorum(PM);however,it rarely causes neutropenia.Herein,we report the case of a 65-year-old woman with concurrent severe hepatotoxicit... BACKGROUND Various types of drug-induced liver injury are induced by Polygonum multiflorum(PM);however,it rarely causes neutropenia.Herein,we report the case of a 65-year-old woman with concurrent severe hepatotoxicity and agranulocytosis induced by PM.CASE SUMMARY A 65-year-old woman reported with severe hepatotoxicity and agranulocytosis 17 d after ingestion of PM.The results of the Roussel Uclaf Causality Assessment Method demonstrated a highly probable relationship between hepatotoxicity and PM,with a total score of 10.The Naranjo algorithm results indicated that agranulocytosis had a probable relationship with PM,with an overall score of 6.Granulocyte colony-stimulating factor(for once),a steroid,compound glycyrrhizin,and polyene phosphatidylcholine therapy were initiated.After 15 d of treatment,there was a gradual improvement in liver biochemistry,leukocytes,and neutrophils levels.CONCLUSION Concurrent hepatotoxicity and agranulocytosis are rare and critical adverse drug reactions of PM,which should be highly valued. 展开更多
关键词 Polygonum multiflorum HEPATOTOXICITY AGRANULOCYTOSIS Case report
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Optimization of Preparation and Brewing Process of Radix Polygonum Multiflorum Preparata-Herba Taxilli Tea Bag by Orthogonal Test Combined with Comprehensive Weighted Score Analysis 被引量:1
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作者 Shenggao YIN Hongzhen TANG +2 位作者 Jinlian LI Yute ZHONG Dongyan LIAO 《Medicinal Plant》 CAS 2019年第5期60-63,68,共5页
[Objectives]This study aimed to optimize the preparation process of Radix Polygonum Multiflorum Preparata-Herba Taxilli tea bags.[Methods]Taking the comprehensive weighed score of total flavonoid content,soup color,ar... [Objectives]This study aimed to optimize the preparation process of Radix Polygonum Multiflorum Preparata-Herba Taxilli tea bags.[Methods]Taking the comprehensive weighed score of total flavonoid content,soup color,aroma and taste as an indicator,the preparation process of tea bags was optimized using an orthogonal test.[Results]The results of the orthogonal test show that the optimal preparation process for the Radix Polygonum Multiflorum Preparata-Herba Taxilli tea bags are as follows:particle size of 14 meshes,solid to liquid ratio of 1∶40,brewing temperature of 70℃,and brewing time of 10 min.[Conclusions]The optimized preparation process is reasonable and feasible.It is suitable for the production of Radix Polygonum Multiflorum Preparata-Herba Taxilli tea bags. 展开更多
关键词 RADIX POLYGONUM multiflorum Preparata-Herba Taxilli TEA BAG Total FLAVONOIDS Orthogonal process SENSORY evaluation
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Italian Ryegrass (Lolium perenne ssp. multiflorum) and Corn (Zea mays) Competition 被引量:1
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作者 Vijay K. Nandula 《American Journal of Plant Sciences》 2014年第26期3914-3924,共11页
Italian ryegrass is an annual/biennial grass that is typically used as a pasture crop or a cover crop along roadsides, rights-of-way, and industrial areas. Glyphosate-resistant (GR) Italian ryegrass populations have b... Italian ryegrass is an annual/biennial grass that is typically used as a pasture crop or a cover crop along roadsides, rights-of-way, and industrial areas. Glyphosate-resistant (GR) Italian ryegrass populations have been documented around the world, mostly in orchard and vineyard situations. The first evidence of evolved GR Italian ryegrass in row/agronomic crops was reported from Washington County, Mississippi in 2005. GR Italian ryegrass populations can jeopardize preplant burndown options in reduced-tillage crop production systems, thereby, delaying planting operations. The effects of competition of Italian ryegrass on crop growth and yield are poorly understood. A field study was conducted in the 2012 growing season and repeated in the 2013 growing season. GR and susceptible (GS) Italian ryegrass populations were established in the greenhouse and transplanted in prepared corn row beds in the fall of 2011 and 2012 at 0, 1, 2, 3, and 4 plants·meter> of crop row. Italian ryegrass plants overwintered and developed over the following spring-summer. Glyphosate was applied at 1.26 kg·ae/ha (1.5× of labeled rate) in the spring to burndown the Italian ryegrass plants and corn was planted into the ryegrass residue 2 - 3 wk later. Current corn production practices were followed. Corn density (early and late season), height (early season), and yield and Italian ryegrass biomass (early-mid season) measurements were recorded during both years. Corn height was greater in 2012 than that in 2013 at comparable stages of the growing season, due to a cooler and wetter early season in 2013 than that in 2012. Averaged across weed densities, corn density (both early and late season) and yield were higher in the GS than those in the GR population, but Italian ryegrass biomass was similar for both populations. Averaged across Italian ryegrass populations, corn density (both early and late season), and yield were inversely proportional to Italian ryegrass density. In summary, Italian ryegrass significantly reduced corn density and yield and reduction was greater with the GR than that with the GS population. Studies are underway to study inter population competition in Italian ryegrass and investigate allelopathic effects of Italian ryegrass on selected crops. 展开更多
关键词 COMPETITION CORN Interference Italian RYEGRASS LOLIUM perenne ssp. multiflorum (Lam.) Husnot Zea mays L.
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Seed Size Effects on Early Seedling Growth and Response to Applied Nitrogen in Annual Ryegrass (<i>Lolium multiflorum</i>L.) 被引量:1
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作者 Paul W. Bartholomew 《Agricultural Sciences》 2015年第10期1232-1238,共7页
Use of individual plants as experimental units may be necessary when resources are limited, but inter-plant variation risks obscuring differences among treatments. Experiments were undertaken to measure the effects of... Use of individual plants as experimental units may be necessary when resources are limited, but inter-plant variation risks obscuring differences among treatments. Experiments were undertaken to measure the effects of seed size on seedling size and response to applied nitrogen of annual ryegrass (Lolium multiflorum L.) harvested six or nine weeks after emergence. In two series of experiments, shoot and root dry weights of seedlings increased respectively at means of 53 - 61 and 29 - 30 mg·mg-1 increase in mean seed weight. Between the largest and smallest seed sizes used in this study, there was 83% difference in shoot weight at harvest six weeks after emergence and 22% difference with harvest nine weeks after emergence. Nitrogen (N) application, in comparison, increased shoot dry weights by averages of 69% and 77% with harvests at six or nine weeks, respectively. Dry mass response to N application was similar across seed size categories in shoots or roots. A mean 30% of total seedling-N was retained in roots. Nitrogen utilization efficiency for shoot growth (increase in shoot growth per unit increase in shoot N capture) ranged from 64 mg·mg-1 with harvest six weeks after emergence to 114 mg·mg-1 with harvest at nine weeks after emergence. Delay in seedling harvest from six to nine weeks post-emergence and use of closely-graded seed can reduce variation in individual seedling size and contribute to reduction in random variation in small-scale experiments. 展开更多
关键词 SEED Size SEEDLING Growth LOLIUM multiflorum
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多花黑麦草(Lolium multiflorum Lam)籽粒收获适期的研究 被引量:2
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作者 何亚丽 胡雪华 +1 位作者 邵游 袁韶红 《上海农学院学报》 1993年第3期214-221,共8页
1990~1992年对多花黑麦草(LoLium multiflorum Lam)俄勒岗品种的3个不同生长条件的群体进行了开花后当天至花后30天内的籽粒灌浆,脱落现象的研究,结果表明:3个群体的千粒重和脱落率与花后天数的关系均符合 Logistic 理论曲线.单穗籽粒... 1990~1992年对多花黑麦草(LoLium multiflorum Lam)俄勒岗品种的3个不同生长条件的群体进行了开花后当天至花后30天内的籽粒灌浆,脱落现象的研究,结果表明:3个群体的千粒重和脱落率与花后天数的关系均符合 Logistic 理论曲线.单穗籽粒干物重最大值出现在花后18~24天.花后15~18天的种子已具有较高发芽率(64.3%~91.1%),与以后各期收获的种子间无显著差异,但以花后18~24天的种子发芽苗质较好.据此.上海地区多花黑麦草种子的最佳收获期为花后18天~24天. 展开更多
关键词 多花黑麦草 收获期
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Hypoglycemic effects of naturally processed Polygonum multiflorum extract in KK CgAy/J mice and its mechanism of action
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作者 Wenping Tang Jianfeng Zhan +2 位作者 Shiming Li Yue Liu Chi-Tang Ho 《Food Science and Human Wellness》 SCIE 2022年第5期1177-1182,共6页
In 2021,there are approximately 537 million adults ageing 20-79 years affected by diabetes worldwide and the number is rising rapidly,hence it is important to manage and control diabetes mellitus and its associated co... In 2021,there are approximately 537 million adults ageing 20-79 years affected by diabetes worldwide and the number is rising rapidly,hence it is important to manage and control diabetes mellitus and its associated complications.Food is one of the key factors in preventing and combating diseases such as diabetes.Both as a food and an herbal medicine,Polygonum multiflorum(PM)has been used as an anti-aging tonic,for hair darkening in traditional Chinese medicine for several centuries.The recent research effort of PM has been focused on antioxidant,anti-ageing and anti-tumor properties.In the present study,we utilized the traditional processing of harvested raw PM,and identified several stilbene components and then evaluated the potential anti-diabetic effects of the processed PM extract(PME).PME(0.075%)was given to diabetic mice(KK CgAy/J)in drinking water and after 7 weeks,PME-treated mice had significantly lower glucose levels than mice in the diabetic control group(P<0.01).The mechanism was explored with ELISA and Western blotting and results suggested that the effect was through maintainingβ-cell function. 展开更多
关键词 DIABETES Stilbene glycoside Polygonum multiflorum Hypoglycemic activity Homeostatic model assessment
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New jatropholane-type diterpenes from Jatropha curcas cv.Multiflorum CY Yang
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作者 Yuan-Feng YANG Jie-Qing LIU +2 位作者 Lei SHI Zhong-Rong LI Ming-Hua QIU 《Natural Products and Bioprospecting》 CAS 2013年第3期99-102,共4页
Three new jatropholane-type diterpenoids,jatropholones C-E(1-3),along with seven other known compounds,including sikkimenoid B(4),jatrophaldehyde(5),epi-jatrophaldehyde(6),epi-jatrophol(7),jatrophol(8),jatropholone A(... Three new jatropholane-type diterpenoids,jatropholones C-E(1-3),along with seven other known compounds,including sikkimenoid B(4),jatrophaldehyde(5),epi-jatrophaldehyde(6),epi-jatrophol(7),jatrophol(8),jatropholone A(9),and jatropholone B(10),were isolated from the roots of a natural cultivar of Jatropha curcas(J.curcas cv.Multiflorum CY Yang).The structural elucidations of 1-3 were accomplished by extensive NMR analysis.Compounds 4,6,and 8 demonstrated inhibition activity against the microorganisms with the MIC values from 0.10 to 0.18 mg/mL. 展开更多
关键词 Jatropha curcas cv.multiflorum EUPHORBIACEAE DITERPENES ANTIBACTERIAL
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Madagascar High Lands Dry Season Forages: Lofium multiflorum (Italian Ray Grass) and Avena sativa (Oat)
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作者 Isabelle Herisoa Hantanirina Olivier Jean Rakotonirina Rivo Nirina Rabearimisa Jean de Neupomuscene Rakotozandriny 《Journal of Environmental Science and Engineering(B)》 2014年第6期316-324,共9页
Italian ray grass and oat are two grass species characterized by their ability to adjust tropical climate conditions. This study proposed to assess forage productivities to allow an appropriate mowing period determina... Italian ray grass and oat are two grass species characterized by their ability to adjust tropical climate conditions. This study proposed to assess forage productivities to allow an appropriate mowing period determination in their use as dairy female feed in Madagascar. A test on small plots has been set up in the southern part of the capital city Antananarivo during one dry period (4 months). Live observations followed by laboratory proximate analyses have been performed for forage productivity and feeding value determination. Cultivated on tanety (hill), irrigated in counter season, results show that: (I) oat higher height (H = 96.7 cm) than Italian ray grass (H= 69.4 cm) at 99 days of age; (2) similar biomass productivity; (3) dry matter yields significantly different (p = 0.05); (4) certain similarity between dry matter yields and FMU (fodder milk unit) score evolution; (5) leafy stage of Italian ray grasses at 99 days of age; (6) mid-flowering stage for oats during the same period. Cell wall content, crude fiber and dry matter contents increased with age (p = 0.05). Crude proteins and minerals evolved in opposite directions. Gross energy content did not present precise variation with age. This study allowed that for an acceptable quantitative and qualitative production during dry seasons, good mowing period for Italian ray grass could start at 76 days age, while oat could start being harvested at 68 days. 展开更多
关键词 Counter season forages productivity feeding values Lolium multiflorum Avena sativa Madagascar.
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N-Acetyl Cysteine to Treat <i>Polygonum multiflorum</i>Hepatotoxicity: A Case Report
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作者 Musa S. ALfaifi Kassem A. Barada +5 位作者 Ziad N. Kazzi Zeina S. Mneimneh Eveline A. Hitti Maher A. Malaeb Santina A. Mustapha Melissa H. Gittinger 《Case Reports in Clinical Medicine》 2021年第1期1-7,共7页
<strong>Background:</strong> <em>Polygonum multiflorum</em> (brand name Fo-ti) is a Chinese herb used as an antioxidant, antiaging agent, and liver and kidney health. It can cause acute hepatot... <strong>Background:</strong> <em>Polygonum multiflorum</em> (brand name Fo-ti) is a Chinese herb used as an antioxidant, antiaging agent, and liver and kidney health. It can cause acute hepatotoxicity and even death. There is no published data on the effectiveness of N-Acetyl cysteine (NAC) as a sole effective therapy. <strong>Case:</strong> A 23-year-old, healthy male, presented with jaundice and malaise of one-month duration. He had been taking a Chinese herb named Fo-Ti for 2 months. Physical examination revealed jaundice, with no stigmata of chronic liver disease. His laboratory results showed transaminitis with markedly elevated transaminases. Testings for infectious and autoimmune causes were unremarkable. The patient was admitted to the hospital. Fo-Ti was stopped and he was started on oral NAC as peroral protocol. He was discharged home on esomeprazole and oral NAC. He returned on the second day with worsening jaundice. He was readmitted and esomeprazole was discontinued. NAC was continued and his liver enzymes eventually improved. The supplement was tested by gas-chromatography mass spectrometry and measured the presence of emodin. <strong>Discussion:</strong> This case highlights the potential benefit of NAC as treatment of <em>Polygonum multiflorum</em> induced hepatotoxicity. The proposed mechanism of emodin induced liver injury is through disturbing glutathione metabolism in liver cells. This could explain the favorable response as NAC has the ability to replenish intracellular glutathione. <strong>Conclusion:</strong> <em>Polygonum multiflorum</em> use has been associated with severe and prolonged hepatotoxicity. Oral NAC should be considered in the treatment of these patients due to the favorable risk-benefit ratio. 展开更多
关键词 Polygonum multiflorum N-Ace Tylcysteine HEPATOTOXICITY
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Transcriptional regulation effect of constituents in Polygonum multiflorum Thunb. based on human progesterone X receptor(hPXR) mediated CYP3A4 rapid screening system
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作者 Zhao-yan ZHANG Yu-guang WANG Yue GAO 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2018年第4期339-340,共2页
OBJECTIVE This study investigated transcriptional regulation of the main chemical con.stituents of Polygonum multiflorum Thunb.including Stilbene Glucoside(THSG) and anthraquinone constituents(Emodin,Rhein,Aloeemodin,... OBJECTIVE This study investigated transcriptional regulation of the main chemical con.stituents of Polygonum multiflorum Thunb.including Stilbene Glucoside(THSG) and anthraquinone constituents(Emodin,Rhein,Aloeemodin,Chrysophanol and Physcion) and six potential liver injury constituents(gallic acid,quercetin,luteolin,kaempferol,resveratrol) on mediated by PXR CYP3A4.Early establishment of pregnane X receptor mediated CYP3A4 drug induced rapid screening technique was used to determine the effects of these constituents.METHODS First,effect of constituents on the cell activity was detected by MTS cell viability assay.IC50 was calculated.Second,the expression vector and reporter vector were co-transfected into Hep G2 cells,10 μmol·L^(-1) Rifampicin as a positive control,10 μmol·L^(-1) Ketoconazole as a negative control.After treated with different concentrations of(the an.thraquinone constituents concentrations were 2.5,5 and 10 μmol·L^(-1);the concentrations of Gallic Acid,Quercetin,Luteolin,Kaempferol,Apigenin,Resveratrol concentrations were 5,10 and 20 μmol·L^(-1)) for24 h,the cells were tested for dual luciferase activity.RESULTS The results show that the inhibitory ef.fect of THSG,Chrysophanol,Emodin,Rhein and Aloeemodin on CYP3A4 was inhibited by co-transfec.tion of pcDNA3.1 and pGL4.17-CYP3A4.The expression of pcDNA3.14-PXR and pGL4.17-CYP3A4 was induced by the four constituents.Besides,Emodin has a directly inducing effect.Four anthraqui.none constituentscan induce the effect of CYP3A4 by PXR,but Emodin can directly induce CYP3A4.THSG can inhibit CYP3A4,but in the presence of PXR plasmid can induce CYP3A4.For the six poten.tial liver injury constituents,results show that the plasmid pcDNA3.1 was cotransfected with pGL4.17-CYP3A4 regulation of Gallic Acid and Resveratrol on CYP3A4 inhibitory effects of Quercetin,Luteolin,Kaempferol have an induce effect;after pcDNA3.14-PXR and pGL4.17-CYP3A4 cotransfected,Quercetin,Luteolin,Kaempferol,Apigenin,Resveratrol have induced effect,three constituents' induc.tion effect had significant difference.CONCLUSION 12 kinds of Polygonum multiflorum Thunb.constit.uents have inhibitory or activating effects on CYP3A4,after the participation of PXR,9 components have induced effects on CYP3A4,and the induction effect of 6 components has significant difference.The results suggested that we should pay attention to potential drug interactions when combined with Polygonum multiflorum Thunb.,and improve safety and efficacy. 展开更多
关键词 何首乌 肝损伤 治疗方法 临床分析
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Simultaneous quantitative determination of eight active components in Polygonum multiflorum Thunb by RP-HPLC 被引量:7
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作者 续艳丽 董琦 胡凤祖 《Journal of Chinese Pharmaceutical Sciences》 CAS 2009年第4期358-361,共4页
A sensitive and specific reversed-phase high performance liquid chromatography (RP-HPLC) method was established for the simultaneous quantitative determination of eight active components, two stilbenes (resveratrol... A sensitive and specific reversed-phase high performance liquid chromatography (RP-HPLC) method was established for the simultaneous quantitative determination of eight active components, two stilbenes (resveratrol, polydatin) and six flavonoids (rutin, quercilrin, quercetin, luteotin, isoorientin, kaempferol), in Polygonum multiflorum Thunb. The chromatographic separation was performed on a Kromasil C18 column (250 mm^4.6 mm, 5 ~tm), and gradient elution was carried out with water-methanol as the mobile phase at a flow rate of 1 mL/min. Stilbenes and flavonoids were respectively detected at 320 nm and 350 nm with DAD. The correlation coefficients of all the calibration curves were found to be higher than 0.9995. The average recoveries were ranged from 96.8% to 102.5% with RSD less than 4.8% for these components. RP-HPLC was validated to be a robust method for the quantitative determination of active components in Polygonum multiflorum Thunb, and it could be used in the quality control of this traditional medicine. 展开更多
关键词 RP-HPLC STILBENES FLAVONOIDS Polygonum multiflorum Thunb
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何首乌叶不同萃取物的抗炎活性及其化学成分鉴定
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作者 吴静 谢传奇 +4 位作者 徐志勇 吴磊 刘云飞 熊伟 徐敢珍 《中国食品学报》 EI CAS CSCD 北大核心 2024年第4期411-419,共9页
目的:研究何首乌叶的成分,为其功能食品的研发提供基础数据。方法:对何首乌叶醇提取物进行有机溶剂萃取,分别得到何首乌叶石油醚、二氯甲烷、乙酸乙酯、正丁醇、水等不同萃取物,并对不同萃取物进行抗炎活性检测,后续通过硅胶柱色谱、C1... 目的:研究何首乌叶的成分,为其功能食品的研发提供基础数据。方法:对何首乌叶醇提取物进行有机溶剂萃取,分别得到何首乌叶石油醚、二氯甲烷、乙酸乙酯、正丁醇、水等不同萃取物,并对不同萃取物进行抗炎活性检测,后续通过硅胶柱色谱、C18柱色谱结合半制备液相等方法对抗炎活性较好的成分进行分离、纯化以及结构鉴定,结果:在质量浓度0~100μg/mL范围内,乙酸乙酯萃取物对RAW264.7细胞存活率无明显的抑制作用,且剂量依赖地抑制NO的生成。石油醚和二氯甲烷萃取物在质量浓度0~25μg/mL时,均无明显细胞毒性,并在25μg/mL时,二氯甲烷萃取物对NO的抑制率(51.47%)高于石油醚萃取物的抑制率(43.91%)。从二氯甲烷和乙酸乙酯萃取物中分离、鉴定出11个化合物,分别为2,3,4,6-三羟基苯乙酮-3-O-β-D-glucoside(1)、杨梅苷(2)、槲皮苷(3)、阿福豆苷(4)、β-谷甾醇(5)、正十六烷-5,8,11三烯酸(6)、二十六烷(7)、α-亚麻酸(8)、山柰酚-3-O-芸香糖苷(9)、肉豆蔻酸(10)和槲皮素(11)。结论:何首乌叶具有很好的抗炎活性,化合物2,4,6,7,8,9,10,11均为首次从何首乌中分离得到。 展开更多
关键词 何首乌叶 抗炎活性 化学成分 RAW264.7 黄酮苷
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基于生态位模型的多花黑麦草入侵风险分析 被引量:2
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作者 陈瑜 杨毅哲 +7 位作者 陈丽丽 宋兴江 李欣迪 张献瑞 史岩 王佳 宋雅琪 刘刚 《陕西师范大学学报(自然科学版)》 CAS CSCD 北大核心 2024年第1期70-78,共9页
外来植物多花黑麦草的入侵对陕西、河南、江苏、四川等地的农业生产造成了严重危害。为构建多花黑麦草入侵风险预警,利用主成分分析模型和最大熵模型对多花黑麦草在入侵中国后的生态位分化及在中国的入侵阶段进行分析。结果表明,多花黑... 外来植物多花黑麦草的入侵对陕西、河南、江苏、四川等地的农业生产造成了严重危害。为构建多花黑麦草入侵风险预警,利用主成分分析模型和最大熵模型对多花黑麦草在入侵中国后的生态位分化及在中国的入侵阶段进行分析。结果表明,多花黑麦草在入侵我国后发生了显著的生态位漂移;相比于其原产地种群,多花黑麦草在中国的入侵种群生态位宽度更广,适应的气候区显著扩展;在当前气候条件下,中国南方大部分区域属于多花黑麦草的稳定入侵区,而北方和西部地区存在其局域适应区和潜在拓殖区。研究结果反映出多花黑麦草在我国东中部大部分地区具有较高的入侵潜力,也暗示了多花黑麦草较高的生态位进化能力可能是其在我国广泛入侵的重要原因。研究结果为开展多花黑麦草的防控和治理提供了重要研究基础。 展开更多
关键词 多花黑麦草 MaxEnt模型 生态位漂移 入侵阶段
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何首乌肝损伤机制及减毒方法研究进展 被引量:1
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作者 刘思雨 李敏 +4 位作者 唐瑜 张依娜 欧莉 卫培峰 高峰 《中南药学》 CAS 2024年第4期1008-1015,共8页
何首乌Polygonum multiforum Thunb.是临床常用滋补中药,同时作为一种保健中药在药膳和食膳中广泛应用,但是近年来由于不时出现何首乌及其制品致肝损伤的报道,引起了研究者的警觉及关注。本文通过整理分析关于何首乌致肝损伤的国内外临... 何首乌Polygonum multiforum Thunb.是临床常用滋补中药,同时作为一种保健中药在药膳和食膳中广泛应用,但是近年来由于不时出现何首乌及其制品致肝损伤的报道,引起了研究者的警觉及关注。本文通过整理分析关于何首乌致肝损伤的国内外临床相关报道,从何首乌致肝毒性的物质基础二苯乙烯苷类、蒽醌类化合物和没食子酸等成分及其潜在肝毒性机制(包括代谢酶改变、氧化应激、炎症反应、线粒体损伤、肝细胞异常凋亡等方面)进行归纳总结,探讨炮制减毒和配伍减毒两种减毒方法对何首乌肝毒性的影响和机制。 展开更多
关键词 何首乌 肝毒性 炮制 配伍 减毒增效
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何首乌属化学成分与药理作用研究进展 被引量:1
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作者 王冯瑞 唐子龙 +6 位作者 王宇轩 冯改利 张欧文 宋小妹 李玉泽 张东东 王薇 《陕西中医药大学学报》 2024年第3期136-150,共15页
何首乌属植物作为一类重要的药用植物资源,一直以来都是国内外学者研究的热点。何首乌属植物化学成分的研究表明,该属植物中主要含有二苯乙烯类、黄酮类、醌类、生物碱类等多种化学成分。民间用药经验及现代研究证实何首乌属植物具有抗... 何首乌属植物作为一类重要的药用植物资源,一直以来都是国内外学者研究的热点。何首乌属植物化学成分的研究表明,该属植物中主要含有二苯乙烯类、黄酮类、醌类、生物碱类等多种化学成分。民间用药经验及现代研究证实何首乌属植物具有抗肿瘤、抗炎、抗菌、调节免疫等药理活性。现对何首乌属植物近年来化学成分和药理作用的研究进行总结归纳,旨在为何首乌属植物进一步的研究和合理开发利用提供参考。 展开更多
关键词 何首乌属 化学成分 药理作用
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