Background:China has achieved zero indigenous malaria case report in 2017.However,along with the increasing of international cooperation development,there is an increasing number of imported malaria cases from Chinese...Background:China has achieved zero indigenous malaria case report in 2017.However,along with the increasing of international cooperation development,there is an increasing number of imported malaria cases from Chinese nationals returning from malaria-affeaed countries.Previous studies have focused on malaria endemic areas in China.There is thus limited information on non-endemic areas in China,especially on the performance of malaria surveillance and response in health facilities.Methods:A comparative retrospective study was carried out based on routine malaria surveillance data collected from 2013 to 2017.All imported malaria cases reported within the mainland of China were included.Variables used in the comparative analysis between cases in former endemic and former non-endemic areas,included age,gender and occupation,destination of overseas travel,Plasmodium species and patient health outcome.Monthly aggregated data was used to compare seasonal and spatial characteristics.Geographical distribution and spatial-temporal aggregation analyses were conducted.Time to diagnosis and report,method of diagnosis,and level of reporting/diagnosing health facilities were used to assess performance of health facilities.Results:A total of 16733 malaria cases,out of which 90 were fatal,were recorded in 31 provinces.The majority of cases(96.2%)were reported from former malaria endemic areas while 3.8%were reported from former non-malaria endemic areas.Patients in the age class from 19 to 59 years and males made the highest proportion of cases in both areas.There were significant differences between occupational categories in the two areas(P c 0.001).In former endemic areas,the largest proportion of cases was among outdoor workers(80%).Two peaks(June,January)and three peaks(June,September and January)were found in former endemic and former non-endemic areas,respeaively.Time between the onset of symptoms and diagnosis at clinics was significantly different between the two areas at different level of health facilities(P<0.05).Conclusions:All the former non-endemic areas are now reporting imported malaria cases.However,the largest proportion of imported cases is still reported from former endemic areas.Health facilities in former endemic areas outperformed those in former non-endemic areas.Information,treatment,and surveillance must be provided for expatriates while capacity building and continuous training must be implemented at health facilities in China.展开更多
Background: Malaria infection during pregnancy is a major public health problem in tropical and subtropical regions globally. Anaemia is often an adverse outcome of severe parasitic infections during pregnancy in deve...Background: Malaria infection during pregnancy is a major public health problem in tropical and subtropical regions globally. Anaemia is often an adverse outcome of severe parasitic infections during pregnancy in developing countries. Pregnant women in malaria-endemic communities are more susceptible to Plasmodium falciparum infections than non-pregnant women of child-bearing age. Objective: To comparatively investigate malaria and anaemia in pregnant and non-pregnant women of child-bearing age. Design: A cross-sectional comparative study. Three hundred and eighty pregnant women and 380 non-pregnant women were screened for the study. Setting: The study was conducted at the University Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Measurements: Participants’ demographic data were collected via the administration of questionnaires. In addition their blood samples were analyzed for haemoglobin level and malaria parasites, while stool samples from the pregnant women were examined for intestinal parasites. Results: The study revealed that pregnant women have higher malaria parasitaemia (12.6%) and anaemia (62.6%). The species of Plasmodium isolated from the pregnant women were P. falciparum (85.4%), P. malariae (4.2%) and P. ovale (10.4%). Malaria parasitaemia was higher in the primigravidae (14%). However multigravidae recorded the highest anaemia prevalence (67.1%). Age of pregnant women was a factor affecting malaria parasitaemia with a significant P-value and OR (P value = 0.0041, 0R = 7.61). Conclusions: Pregnant women were more susceptible to malaria and anaemia than non-pregnant women of child-bearing age. Most of the pregnant women reported at antenatal clinic during the second trimester. Primigravidae however recorded the highest malaria parasitaemia. The main species of Plasmodium observed in the blood samples was falciparum.展开更多
<p align="justify"> <span style="font-family:Verdana;"></span><strong>Background:</strong> Malaria is one of the main health problems in Yemen. Health education is ess...<p align="justify"> <span style="font-family:Verdana;"></span><strong>Background:</strong> Malaria is one of the main health problems in Yemen. Health education is essential for the control of diseases such as malaria. School-age children represent 25% of Yemen’s population. Schools children can convey the knowledge and skills that they acquire at school to the community, thus increasing general community awareness about malaria. Aim to determine the impact of school-based malaria education intervention on knowledge, attitude and practice of school children towards malaria prevention and control. <strong>Methods: </strong>We conducted a community-based trial, intervention and non-intervention comparison (exposed & non-exposed), in four randomly selected districts (rural and urban) of Taiz governorate. This study was conducted in four districts of Taiz governorate. The study population was 2130 pupils of grade 6, 7, and 8 in primary schools, chosen from four randomly selected districts;two of them were rural and the others urban. Four schools and their pupils (1065 pupils) were chosen for the study and assigned as an intervention group and four schools with their pupils (1065) were chosen for the study and assigned as a non-intervention (1065 pupils). Data were collected using questioner in intervention and non-intervention schools (three months apart). The major intervention activities included lectures about malaria, distribution of educational materials. χ<sup>2</sup> was used to analyze differences. <strong>Results: </strong>Health education activities in schools were associated with the increased knowledge of malaria symptoms and methods of prevention. The mean knowledge of malaria symptoms is higher in the intervention schools 4.4 ± 1.9, compared with 2.1 ± 1.4 in the non-intervention group. With statistically significant difference (P < 0.001), also the positive attitude and practice toward malaria was higher to be (48%) in the intervention group;compared with (35%) in the non-intervention group the difference was statistically significant. The knowledge of mode of malaria transmission was higher in the intervention schools to be (86.2%) compared with (59.1%) in the non-intervention group, with statistically significant deference (P value <0.001). The knowledge of fever as a main malaria symptom was higher to be (90.4%) in the intervention schools compared with (63.6%) in the non-intervention schools with statistically significant deference. <strong>Conclusions and Recommendation: </strong>This study concludes that the health education intervention in primary schools in Taize governorate had a positive impact on the knowledge, attitude and practice of pupils. We recommend to conduct similar methods of the health education activities in schools with suitable modifications to reach all schools level. </p>展开更多
We propose and analyze an epidemiological model to evaluate the effectiveness of bed nets as a prophylactic measure in malaria-endemic areas. The main purpose in this work is the modeling of the aggressiveness of anop...We propose and analyze an epidemiological model to evaluate the effectiveness of bed nets as a prophylactic measure in malaria-endemic areas. The main purpose in this work is the modeling of the aggressiveness of anopheles mosquitoes relative to the way humans use to protect themselves against bites of mosquitoes. This model is a system of several differential equations: the number of equations depends on the particular assumptions of the model. We compute the basic reproduction number, and show that if, the disease free equilibrium (DFE) is globally asymptotically stable on the non-negative orthant. If, the system admits a unique endemic equilibrium (EE) that is globally and asymptotically stable. Numerical simulations are presented corresponding to scenarios typical of malaria-endemic areas, based on data collected in the literature. Finally, we discuss the relative effectiveness of different kinds of bed nets.展开更多
Background:The significant malaria burden in Africa has often eclipsed other febrile illnesses.Burkina Faso’s first dengue epidemic occurred in 1925 and the most recent in 2013.Yet there is still very little known ab...Background:The significant malaria burden in Africa has often eclipsed other febrile illnesses.Burkina Faso’s first dengue epidemic occurred in 1925 and the most recent in 2013.Yet there is still very little known about dengue prevalence,its vector proliferation,and its poverty and equity impacts.Methods:An exploratory cross-sectional survey was performed from December 2013 to January 2014.Six primary healthcare centers in Ouagadougou were selected based on previously reported presence of Flavivirus.All patients consulting with fever or having had fever within the previous week and with a negative rapid diagnostic test(RDT)for malaria were invited to participate.Sociodemographic data,healthcare use and expenses,mobility,health-related status,and vector control practices were captured using a questionnaire.Blood samples of every eligible subject were obtained through finger pricks during the survey for dengue RDT using SD BIOLINE Dengue Duo(NS1Ag and IgG/IgM)®and to obtain blood spots for reverse transcription polymerase chain reaction(RT-PCR)analysis.In a sample of randomly selected yards and those of patients,potential Aedes breeding sites were found and described.Larvae were collected and brought to the laboratory to monitor the emergence of adults and identify the species.Results:Of the 379 subjects,8.7%(33/379)had positive RDTs for dengue.Following the 2009 WHO classification,38.3%(145/379)had presumptive,probable,or confirmed dengue,based on either clinical symptoms or laboratory testing.Of 60 samples tested by RT-PCR(33 from the positive tests and 27 from the subsample of negatives),15 were positive.The serotypes observed were DENV2,DENV3,and DENV4.Odds of dengue infection in 15-to-20-year-olds and persons over 50 years were 4.0(CI 95%:1.0–15.6)and 7.7(CI 95%:1.6–37.1)times higher,respectively,than in children under five.Average total spending for a dengue episode was 13771 FCFA[1300–67300 FCFA](1$US=478 FCFA).On average,2.6 breeding sites were found per yard.Potential Aedes breeding sites were found near 71.4%(21/28)of patients,but no adult Aedes were found.The most frequently identified potential breeding sites were water storage containers(45.2%).Most specimens collected in yards were Culex(97.9%).Conclusions:The scientific community,public health authorities,and health workers should consider dengue as a possible cause of febrile illness in Burkina Faso.展开更多
文摘Background:China has achieved zero indigenous malaria case report in 2017.However,along with the increasing of international cooperation development,there is an increasing number of imported malaria cases from Chinese nationals returning from malaria-affeaed countries.Previous studies have focused on malaria endemic areas in China.There is thus limited information on non-endemic areas in China,especially on the performance of malaria surveillance and response in health facilities.Methods:A comparative retrospective study was carried out based on routine malaria surveillance data collected from 2013 to 2017.All imported malaria cases reported within the mainland of China were included.Variables used in the comparative analysis between cases in former endemic and former non-endemic areas,included age,gender and occupation,destination of overseas travel,Plasmodium species and patient health outcome.Monthly aggregated data was used to compare seasonal and spatial characteristics.Geographical distribution and spatial-temporal aggregation analyses were conducted.Time to diagnosis and report,method of diagnosis,and level of reporting/diagnosing health facilities were used to assess performance of health facilities.Results:A total of 16733 malaria cases,out of which 90 were fatal,were recorded in 31 provinces.The majority of cases(96.2%)were reported from former malaria endemic areas while 3.8%were reported from former non-malaria endemic areas.Patients in the age class from 19 to 59 years and males made the highest proportion of cases in both areas.There were significant differences between occupational categories in the two areas(P c 0.001).In former endemic areas,the largest proportion of cases was among outdoor workers(80%).Two peaks(June,January)and three peaks(June,September and January)were found in former endemic and former non-endemic areas,respeaively.Time between the onset of symptoms and diagnosis at clinics was significantly different between the two areas at different level of health facilities(P<0.05).Conclusions:All the former non-endemic areas are now reporting imported malaria cases.However,the largest proportion of imported cases is still reported from former endemic areas.Health facilities in former endemic areas outperformed those in former non-endemic areas.Information,treatment,and surveillance must be provided for expatriates while capacity building and continuous training must be implemented at health facilities in China.
文摘Background: Malaria infection during pregnancy is a major public health problem in tropical and subtropical regions globally. Anaemia is often an adverse outcome of severe parasitic infections during pregnancy in developing countries. Pregnant women in malaria-endemic communities are more susceptible to Plasmodium falciparum infections than non-pregnant women of child-bearing age. Objective: To comparatively investigate malaria and anaemia in pregnant and non-pregnant women of child-bearing age. Design: A cross-sectional comparative study. Three hundred and eighty pregnant women and 380 non-pregnant women were screened for the study. Setting: The study was conducted at the University Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Measurements: Participants’ demographic data were collected via the administration of questionnaires. In addition their blood samples were analyzed for haemoglobin level and malaria parasites, while stool samples from the pregnant women were examined for intestinal parasites. Results: The study revealed that pregnant women have higher malaria parasitaemia (12.6%) and anaemia (62.6%). The species of Plasmodium isolated from the pregnant women were P. falciparum (85.4%), P. malariae (4.2%) and P. ovale (10.4%). Malaria parasitaemia was higher in the primigravidae (14%). However multigravidae recorded the highest anaemia prevalence (67.1%). Age of pregnant women was a factor affecting malaria parasitaemia with a significant P-value and OR (P value = 0.0041, 0R = 7.61). Conclusions: Pregnant women were more susceptible to malaria and anaemia than non-pregnant women of child-bearing age. Most of the pregnant women reported at antenatal clinic during the second trimester. Primigravidae however recorded the highest malaria parasitaemia. The main species of Plasmodium observed in the blood samples was falciparum.
文摘<p align="justify"> <span style="font-family:Verdana;"></span><strong>Background:</strong> Malaria is one of the main health problems in Yemen. Health education is essential for the control of diseases such as malaria. School-age children represent 25% of Yemen’s population. Schools children can convey the knowledge and skills that they acquire at school to the community, thus increasing general community awareness about malaria. Aim to determine the impact of school-based malaria education intervention on knowledge, attitude and practice of school children towards malaria prevention and control. <strong>Methods: </strong>We conducted a community-based trial, intervention and non-intervention comparison (exposed & non-exposed), in four randomly selected districts (rural and urban) of Taiz governorate. This study was conducted in four districts of Taiz governorate. The study population was 2130 pupils of grade 6, 7, and 8 in primary schools, chosen from four randomly selected districts;two of them were rural and the others urban. Four schools and their pupils (1065 pupils) were chosen for the study and assigned as an intervention group and four schools with their pupils (1065) were chosen for the study and assigned as a non-intervention (1065 pupils). Data were collected using questioner in intervention and non-intervention schools (three months apart). The major intervention activities included lectures about malaria, distribution of educational materials. χ<sup>2</sup> was used to analyze differences. <strong>Results: </strong>Health education activities in schools were associated with the increased knowledge of malaria symptoms and methods of prevention. The mean knowledge of malaria symptoms is higher in the intervention schools 4.4 ± 1.9, compared with 2.1 ± 1.4 in the non-intervention group. With statistically significant difference (P < 0.001), also the positive attitude and practice toward malaria was higher to be (48%) in the intervention group;compared with (35%) in the non-intervention group the difference was statistically significant. The knowledge of mode of malaria transmission was higher in the intervention schools to be (86.2%) compared with (59.1%) in the non-intervention group, with statistically significant deference (P value <0.001). The knowledge of fever as a main malaria symptom was higher to be (90.4%) in the intervention schools compared with (63.6%) in the non-intervention schools with statistically significant deference. <strong>Conclusions and Recommendation: </strong>This study concludes that the health education intervention in primary schools in Taize governorate had a positive impact on the knowledge, attitude and practice of pupils. We recommend to conduct similar methods of the health education activities in schools with suitable modifications to reach all schools level. </p>
文摘We propose and analyze an epidemiological model to evaluate the effectiveness of bed nets as a prophylactic measure in malaria-endemic areas. The main purpose in this work is the modeling of the aggressiveness of anopheles mosquitoes relative to the way humans use to protect themselves against bites of mosquitoes. This model is a system of several differential equations: the number of equations depends on the particular assumptions of the model. We compute the basic reproduction number, and show that if, the disease free equilibrium (DFE) is globally asymptotically stable on the non-negative orthant. If, the system admits a unique endemic equilibrium (EE) that is globally and asymptotically stable. Numerical simulations are presented corresponding to scenarios typical of malaria-endemic areas, based on data collected in the literature. Finally, we discuss the relative effectiveness of different kinds of bed nets.
基金This research project is part of the“Community research studies and interventions for health equity in Burkina Faso”We thank the Canadian Institutes of Health Research(CIHR),who funded the program(ROH-115213).V.Ridde holds a CIHR-funded Research Chair in Applied Public Health(CPP-137901).
文摘Background:The significant malaria burden in Africa has often eclipsed other febrile illnesses.Burkina Faso’s first dengue epidemic occurred in 1925 and the most recent in 2013.Yet there is still very little known about dengue prevalence,its vector proliferation,and its poverty and equity impacts.Methods:An exploratory cross-sectional survey was performed from December 2013 to January 2014.Six primary healthcare centers in Ouagadougou were selected based on previously reported presence of Flavivirus.All patients consulting with fever or having had fever within the previous week and with a negative rapid diagnostic test(RDT)for malaria were invited to participate.Sociodemographic data,healthcare use and expenses,mobility,health-related status,and vector control practices were captured using a questionnaire.Blood samples of every eligible subject were obtained through finger pricks during the survey for dengue RDT using SD BIOLINE Dengue Duo(NS1Ag and IgG/IgM)®and to obtain blood spots for reverse transcription polymerase chain reaction(RT-PCR)analysis.In a sample of randomly selected yards and those of patients,potential Aedes breeding sites were found and described.Larvae were collected and brought to the laboratory to monitor the emergence of adults and identify the species.Results:Of the 379 subjects,8.7%(33/379)had positive RDTs for dengue.Following the 2009 WHO classification,38.3%(145/379)had presumptive,probable,or confirmed dengue,based on either clinical symptoms or laboratory testing.Of 60 samples tested by RT-PCR(33 from the positive tests and 27 from the subsample of negatives),15 were positive.The serotypes observed were DENV2,DENV3,and DENV4.Odds of dengue infection in 15-to-20-year-olds and persons over 50 years were 4.0(CI 95%:1.0–15.6)and 7.7(CI 95%:1.6–37.1)times higher,respectively,than in children under five.Average total spending for a dengue episode was 13771 FCFA[1300–67300 FCFA](1$US=478 FCFA).On average,2.6 breeding sites were found per yard.Potential Aedes breeding sites were found near 71.4%(21/28)of patients,but no adult Aedes were found.The most frequently identified potential breeding sites were water storage containers(45.2%).Most specimens collected in yards were Culex(97.9%).Conclusions:The scientific community,public health authorities,and health workers should consider dengue as a possible cause of febrile illness in Burkina Faso.
