Development of a chronic compression spinal cord injury model in neonatal and adult rats

Background:Spinal cord injury presents a significant burden globally,with traumatic spinal cord injury being the predominant cause historically.However,nontraumatic spinal cord injury(NTSCI)is emerging as a significant contributor,particularly in devel-oped nations,yet it remains poorly understood due to underreporting and misclassifi-cation.NTSCI,spanning various etiologies such as bony growths,vascular conditions,infections,neoplastic conditions,and immune disorders,poses unique challenges in diagnosis and treatment,often resulting in lifelong morbidity.This study addresses the lack of suitable animal models for NTSCI research,especially in neonatal animals.Methods:Utilizing a solid spacer approach,we developed a compression NTSCI model applicable to both neonatal and adult Sprague-Dawley rats.Results:Through anatomical measurements and in vivo experiments,we confirmed the feasibility and safety of the spacer insertion procedure and observed no acute off-target effects.Conclusion:The versatility of this model lies in its adaptability to different ages of rats,offering a cost-effective and reproducible means to induce graded injuries.Moreover,behavioral assessments demonstrated observable hindlimb function,validating the model's utility for studying functional outcomes.Although challenges persist,par-ticularly in accounting for spinal column growth in neonatal animals,this model fills a crucial gap in pediatric NTSCI research.By providing a platform to investigate patho-physiological mechanisms and test potential treatments,it offers promising avenues for advancing our understanding and management of pediatric NTSCI.

Differentially private SGD with random features

In the realm of large-scale machine learning,it is crucial to explore methods for reducing computational complexity and memory demands while maintaining generalization performance.Additionally,since the collected data may contain some sensitive information,it is also of great significance to study privacy-preserving machine learning algorithms.This paper focuses on the performance of the differentially private stochastic gradient descent(SGD)algorithm based on random features.To begin,the algorithm maps the original data into a lowdimensional space,thereby avoiding the traditional kernel method for large-scale data storage requirement.Subsequently,the algorithm iteratively optimizes parameters using the stochastic gradient descent approach.Lastly,the output perturbation mechanism is employed to introduce random noise,ensuring algorithmic privacy.We prove that the proposed algorithm satisfies the differential privacy while achieving fast convergence rates under some mild conditions.

Convergence analysis for complementary-label learning with kernel ridge regression

Complementary-label learning(CLL)aims at finding a classifier via samples with complementary labels.Such data is considered to contain less information than ordinary-label samples.The transition matrix between the true label and the complementary label,and some loss functions have been developed to handle this problem.In this paper,we show that CLL can be transformed into ordinary classification under some mild conditions,which indicates that the complementary labels can supply enough information in most cases.As an example,an extensive misclassification error analysis was performed for the Kernel Ridge Regression(KRR)method applied to multiple complementary-label learning(MCLL),which demonstrates its superior performance compared to existing approaches.

THE SPARSE REPRESENTATION RELATED WITH FRACTIONAL HEAT EQUATIONS

This study introduces a pre-orthogonal adaptive Fourier decomposition(POAFD)to obtain approximations and numerical solutions to the fractional Laplacian initial value problem and the extension problem of Caffarelli and Silvestre(generalized Poisson equation).As a first step,the method expands the initial data function into a sparse series of the fundamental solutions with fast convergence,and,as a second step,makes use of the semigroup or the reproducing kernel property of each of the expanding entries.Experiments show the effectiveness and efficiency of the proposed series solutions.

AHermitian C^(2) Differential Reproducing Kernel Interpolation Meshless Method for the 3D Microstructure-Dependent Static Flexural Analysis of Simply Supported and Functionally Graded Microplates

This work develops a Hermitian C^(2) differential reproducing kernel interpolation meshless(DRKIM)method within the consistent couple stress theory(CCST)framework to study the three-dimensional(3D)microstructuredependent static flexural behavior of a functionally graded(FG)microplate subjected to mechanical loads and placed under full simple supports.In the formulation,we select the transverse stress and displacement components and their first-and second-order derivatives as primary variables.Then,we set up the differential reproducing conditions(DRCs)to obtain the shape functions of the Hermitian C^(2) differential reproducing kernel(DRK)interpolant’s derivatives without using direct differentiation.The interpolant’s shape function is combined with a primitive function that possesses Kronecker delta properties and an enrichment function that constituents DRCs.As a result,the primary variables and their first-and second-order derivatives satisfy the nodal interpolation properties.Subsequently,incorporating ourHermitianC^(2)DRKinterpolant intothe strong formof the3DCCST,we develop a DRKIM method to analyze the FG microplate’s 3D microstructure-dependent static flexural behavior.The Hermitian C^(2) DRKIM method is confirmed to be accurate and fast in its convergence rate by comparing the solutions it produces with the relevant 3D solutions available in the literature.Finally,the impact of essential factors on the transverse stresses,in-plane stresses,displacements,and couple stresses that are induced in the loaded microplate is examined.These factors include the length-to-thickness ratio,the material length-scale parameter,and the inhomogeneity index,which appear to be significant.

Solving Neumann Boundary Problem with Kernel-Regularized Learning Approach

We provide a kernel-regularized method to give theory solutions for Neumann boundary value problem on the unit ball. We define the reproducing kernel Hilbert space with the spherical harmonics associated with an inner product defined on both the unit ball and the unit sphere, construct the kernel-regularized learning algorithm from the view of semi-supervised learning and bound the upper bounds for the learning rates. The theory analysis shows that the learning algorithm has better uniform convergence according to the number of samples. The research can be regarded as an application of kernel-regularized semi-supervised learning.

POSITIVE DEFINITE KERNEL IN SUPPORT VECTOR MACHINE(SVM)

The relationship among Mercer kernel, reproducing kernel and positive definite kernel in support vector machine （SVM） is proved and their roles in SVM are discussed. The quadratic form of the kernel matrix is used to confirm the positive definiteness and their construction. Based on the Bochner theorem, some translation invariant kernels are checked in their Fourier domain. Some rotation invariant radial kernels are inspected according to the Schoenberg theorem. Finally, the construction of discrete scaling and wavelet kernels, the kernel selection and the kernel parameter learning are discussed.

Reconstruction of Car-Electric Bicycle Side Collision Based on PC-Crash

A collision model, an automobile model and a multi-rigid-body model in PC-crash are analyzed. By simulating a side collision accident between a car and an electric bicycle (EB), a method that reproduces the car-electric bicycle side collision accident based on PC-crash is presented according to some important information such as the final position, the contacting location between the cyclist and the car. A result is obtained by comparing with the reproduced result, the deformation of accident vehicle and the surveillance video. The rollover direction and fells-over sliding direction after the collision and the contacting location and wrap motion of cyclist and electric bicycle are fitting in with the real situation better compared with the reconstruction result in PC-crash. Then the responsive-surface method and MONTEKARLO method are used in MATLAB to analyze the uncertainty of the vehicle speed in reproduced scene results. And the range of values of the pre-collision speed is obtained which makes the reproduced result more objective and convincible that could provide the basis of the accident assessment.

A novel transposable Mu-like prophage in Bacillus alcalophilus CGMCC 1.3604(ATCC 27647)

Dear Editor,Transposable phages,which are reproduced by transposition(Harshey,2012;Taylor,1963),have been widely applied in the field of biotechnology to manipulate operon/gene fusions,in vivo cloning,randomion mutagenesis,and integration of DNA into bacterial genomes(Abalakina et al.,2008;Akhverdyan et al.,2011).One of the best-studied transposable phages is

Accuracy Analysis of Low Altitude Photogrammetry with Wide-angle Camera

Firstly,the relationship between the accuracy of low altitude aerial photogrammetry and the field angle of camera is made by a quantitative analysis from the theory.The conclusion that the low altitude photogrammetry should use wide-angle camera as much as possible is done.Then,the limitation of the single lens camera to expand field angle and the combined wide-angle camera existing on the market not suitable for light load of low altitude UAV(Unmanned Aerial Vehicle)due to excessive weight are pointed out.The characteristics of combined wide-angle low altitude light camera with self-calibration and self-stabilization developed by the author are described,especially the principle of self-calibration for the combination of static error and dynamic error.Based on the practice of large scale mapping,a technical procedure in aerial photography by taking with wide-angle camera and large overlap simultaneously for improving the accuracy of low altitude photogrammetry is proposed.The typical engineering produced data is used to verity the above theoretical analysis.A technical route for increasing accuracy of low altitude photogrammetry with combined wide-angle camera is expounded.

一张历史照片

此照片中坐石上者焉溥儀,立于石后穿深色坎肩者为隆裕太后,溥儀右一人(照片上左三)为瑾妃,右两人(左一、左二)为慶王奕劻之女。隆裕太后右一人待考,左三人(右一、右二、右三)可能是瑜妃、瑨妃、列妃,亦待考。从衣服来看,拍摄季节当是春夏之交或夏末秋初。徙溥儀體形来看,当是宣统二或三年。档案记載,宣统三年太后舆皇帝自三月至八月驻西苑,不可能在宫内西花園拍照;而慶王之女辛亥年以后不再进宫伺候,则此照当为宣统二年所摄。

一幅照片的风波

摄影术流入清宫,使许多人和事物形象地留在照片中,它虽然是只鳞片爪的形象,但蕴藏着实在、逼真、具体的生活内容,让后人能跨越时空的隔断,看到已消逝了的历史情景,并去体味、去思索。溥儀退位以后,于紫禁城内廷部分维持小朝廷的生活达十三年之久。在他成年后,用以消遣的最大兴趣就是摄影,仅大婚后两年多时间内,就照了上百张姿态各异的照片。为了拍出新意,他独出心裁,穿上特派太监出宫给他置辦的民国将领穿的军服,佩宽皮腰带及军刀,足蹬马靴。

A finite element model of circulation in shallow water with moving boundary on tidal-flat

To examine the circulation in shallow water with tidal flat, a finite element model for the numerical solution of the shallow water equations was developed by means of standard Galerkin's method. The domain computed was covered with triangular finite elements, and water elevation and velocity were approximated by linear interpolation functions, and the lumped coefficients were used to substitute for solving the high order algebraic equation system. The time-dependent land-water boundary changes are treated mathematically by interrelating the location of the land-water boundary with the instantaneous tidal level. The implicit scheme was adopted for the terms of the bottom friction and the Coriolis effect in the motion equation so that the numerical stability of the model has been improved.The model was applied to the tidal current on shoaling water with large tidal flat off Pikou, and a comparison between observed and calculated values showed good agreement, the flow pattern being reproduced. The result shows that the model is able to be widely applied to predicting the circulation in shoaling waters.

Gene therapy for rat myelodysplastic syndrome (MDS)

During the past ten years. our molecular studies haddemonstrated that myelodysplasia of MDS bone marrowwas associated with the rearrangement/amplification ofc-erbB and deletion/ inactivation of c-erbA and identifiedthe sites of the rearrangement by v-erbB PCR genediagnosis of MDS and confirmed their etiogenicsignificance by the follow-up of MDS cases. These resultsprovided 2 target sequences of c-erbB.The

The calculation of the Reproducibility Error in the technological system with the clamp on the gas power

The paper deduced a calculation formula by the classic control theory on the Reproducibility Error of parts processing in the technology system,the flexible clamp system, with the clamping device on the gas power,and analyzed its influencing factor with examples,the Reproducibility Error law:\ The larger the diameter of the cylinder,the smaller the error; the slower the tool speed,(k values smaller),the smaller the error.

Three-body Force Effect from Different Elementary Processes and Relativistic Correction in Dirac-Brueckner Approach

Adopting the charge-dependent ArgonneV_(18) plus microscopic three-body forces,the equation of state(EOS) and single particle properties of symmetric nuclear matter have been investigated in Brueckner-Hartree-Fock(BHF) framework~[1].The microscopic three-body force

Mechanism of soft x-ray continuum radiation from low-energy pinch discharges of hydrogen and ultra-low field ignition of solid fuels

EUV continuum radiation（10–30 nm） arising only from very low energy pulsed pinch gas discharges comprising some hydrogen was first observed at Black Light Power, Inc. and reproduced at the Harvard Center for Astrophysics（Cf A）. The source was determined to be due to the transition of H to the lower-energy hydrogen or hydrino state H（1/4） whose emission matches that observed wherein alternative sources were eliminated. The identity of the catalyst that accepts 3 · 27.2 eV from the H to cause the H to H（1/4） transition was determined to HOH versus 3H. The mechanism was elucidated using different oxide-coated electrodes that were selective in forming HOH versus plasma forming metal atoms as well as from the intensity profile that was a mismatch for the multi-body reaction required during 3H catalysis. The HOH catalyst was further shown to give EUV radiation of the same nature by igniting a solid fuel comprising a source of H and HOH catalyst by passing a low voltage, high current through the fuel to produce explosive plasma. No chemical reaction can release such high-energy light. No high field existed to form highly ionized ions that could give radiation in this EUV region that persisted even without power input. This plasma source serves as strong evidence for the existence of the transition of H to hydrino H（1/4） by HOH as the catalyst and a corresponding new power source wherein initial extraordinarily brilliant light-emitting prototypes are already producing photovoltaic generated electrical power. The hydrino product of a catalyst reaction of atomic hydrogen was analyzed by multiple spectroscopic techniques. Moreover, the m H catalyst was identified to be active in astronomical sources such as the Sun, stars and interstellar medium wherein the characteristics of hydrino match those of the dark matter of the Universe.

Illustrative Cases

A-1.7 days after an electric burn.A-2.40 days after treatment with MEBT.Thewound was filled with the regenerated tis-Sue.30 days after,the epithelia of thewound edge covered the wound to achievethe healing.B-1.A burn involving92 per cent body surfacea rea.B-2.B-3.30 days after treatment with MEBT,thewound was healed.(in zhanjiang)

Intrapuunonary expression of intercellular adhesion molecule-1 gene in rats with acute necrotizing pancreatitis

Objective To investigate intrapulmonary expression of ICAM - I mRNA and the relationship between the expression of ICAM - 1 and lung injury in ANP. Methods ANP was reproduced by retrograde injection of 3. 5 % sodium taurocholate. Animals were sacrified at 1,4,12 and 24 hours after induciton of ancreatitis. Intrapulmonary ICAM - I mRNA expression was assayed by reverse transcription - PCR. The following parameters were also measured:Serum amylase.histologic grading of lung injury and intrapulmonary myeloperoxidase (MPO). Results There was intrapulmonary overexpression of the ICAM -China Medical Abstracts (Surgery) 1 mRNA on the first hour and persisted up to 12 - 24 hours with the increase of serum amylase and intrapulmonary MPO and pancreatitis induction. Score of the lung injury correlated well with the expression of the ICAM- I mRNA and intrapulmonary MPO(r = 0.85,0. 85 and 0.96,all P【0.05).Conclusion The expression of ICAM- I mRNA and pulmonary leucocyte infiltratiorK / was related with lung injury

领袖与故宫

尚未进城已有情毛泽东主席早年就学于长沙湖南省立第一师范学校,是一名品学兼优的好学生。在他的几位情深意笃的老师中,有一位叫作易培基的,他就是故宫博物院的首任院长。易培基于1913年至1922年在湖南省立第一师范学校任教,是毛泽东的国文老师。他十分推重毛泽东的人品、才学,尝谓:“毛泽东将来要当平民天子”。五四运动期间,毛泽东与第一师范学校进步师生一起进行公选校长的活动,公推易培基任第一师范学校校长。易培基任校长后,实行教育改革,聘用了一大批进步人士到校任教,又破格聘用毛泽东为该校附属小学教员,