目的:基于数据挖掘方法探讨中药授治疗慢性前列腺炎的组方规律。方法:收集2023年5月~2024年6月广西中医药大学第一附属医院男科门诊219例慢性前列腺炎患者的中药处方,基于V2.3.5的古今医案云平台,通过数据挖掘的方法对用药组方规律进行...目的:基于数据挖掘方法探讨中药授治疗慢性前列腺炎的组方规律。方法:收集2023年5月~2024年6月广西中医药大学第一附属医院男科门诊219例慢性前列腺炎患者的中药处方,基于V2.3.5的古今医案云平台,通过数据挖掘的方法对用药组方规律进行分析。结果:共纳入治疗慢性前列腺炎的有效处方122首,包含264味中药。使用频次排名前5的药物为橘核、川楝子、桃仁、昆布、海藻;药性以平性、温性、甘性为主;药味以苦味、咸味为主;药物归经以肝经、肾经、胃经为主;使用频次排名前3的功效为疏肝理气、散结止痛、活血祛瘀。药物关联规则分析得出支持度排名前3的为“橘核、川楝子”、“川楝子、桃仁”、“橘核、桃仁”。通过聚类分析共得到3个聚类组合,聚类1为橘核、川楝子、桃仁、昆布、海藻;聚类2为茯苓、五味子、当归、柴胡;聚类3为大血藤、车前子、青皮、牛膝、枳实、荔枝核。122首有效处方的核心药物是橘核、川楝子、桃仁、青皮、昆布、海藻、枳实、荔枝核、大血藤、车前子、茯苓、牛膝、五味子。结论:运用中药治疗慢性前列腺炎以疏肝理气、散结止痛、活血祛瘀为主,兼以利尿通淋,在临床上辨证施治用药拓展了治疗思路。Objective: Exploring the prescription rules of traditional Chinese medicine for the treatment of chronic prostatitis based on data mining methods. Method: Collect traditional Chinese medicine prescriptions from 219 patients with chronic prostatitis in the male outpatient department of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from May 2023 to June 2024. Based on the V2.3.5 ancient and modern medical case cloud platform, analyze the medication prescription rules through data mining methods. Results: A total of 122 effective prescriptions for the treatment of chronic prostatitis were included, including 264 traditional Chinese medicines. The top 5 drugs with the highest frequency of use are orange kernel, Melia azedarach L. seed, peach kernel, kelp, and seaweed;the main medicinal properties are mild, warm, and sweet;the medicinal taste is mainly bitter and salty;the main meridians for medication are the liver meridian, kidney meridian, and stomach meridian;the top three effects of frequent use are soothing the liver and regulating qi, dispersing nodules and relieving pain, and promoting blood circulation and removing blood stasis. The analysis of drug association rules shows that the top three in terms of support are “orange kernel, Melia azedarach L. seed”, “Melia azedarach L. seed, peach kernel”, and “orange kernel, peach kernel”. Through cluster analysis, a total of three cluster combinations were obtained, with cluster 1 being orange kernel, Melia azedarach L. seed, peach kernel, kelp, and seaweed;Cluster 2 includes Poria cocos, Schisandra chinensis, Angelica sinensis, and Bupleurum chinense;Cluster 3 consists of Scutellaria baicalensis, Plantago asiatica, green peel, Achyranthes bidentata, Fructus Aurantii Immaturus, and Lychee seeds. The core drugs of the 122 effective prescriptions are orange kernel, Melia azedarach L. seed, peach kernel, green peel, kelp, seaweed, Fructus Aurantii, lychee kernel, Scutellaria baicalensis, Plantago asiatica, Poria cocos, Achyranthes bidentata, and Schisandra chinensis. Conclusion: The use of traditional Chinese medicine in the treatment of chronic prostatitis mainly focuses on soothing the liver and regulating qi, dispersing nodules and relieving pain, promoting blood circulation and removing blood stasis, while also promoting diuresis and clearing the lymphatic system. In clinical practice, the use of medication based on syndrome differentiation has expanded the treatment approach.展开更多
文摘目的:基于数据挖掘方法探讨中药授治疗慢性前列腺炎的组方规律。方法:收集2023年5月~2024年6月广西中医药大学第一附属医院男科门诊219例慢性前列腺炎患者的中药处方,基于V2.3.5的古今医案云平台,通过数据挖掘的方法对用药组方规律进行分析。结果:共纳入治疗慢性前列腺炎的有效处方122首,包含264味中药。使用频次排名前5的药物为橘核、川楝子、桃仁、昆布、海藻;药性以平性、温性、甘性为主;药味以苦味、咸味为主;药物归经以肝经、肾经、胃经为主;使用频次排名前3的功效为疏肝理气、散结止痛、活血祛瘀。药物关联规则分析得出支持度排名前3的为“橘核、川楝子”、“川楝子、桃仁”、“橘核、桃仁”。通过聚类分析共得到3个聚类组合,聚类1为橘核、川楝子、桃仁、昆布、海藻;聚类2为茯苓、五味子、当归、柴胡;聚类3为大血藤、车前子、青皮、牛膝、枳实、荔枝核。122首有效处方的核心药物是橘核、川楝子、桃仁、青皮、昆布、海藻、枳实、荔枝核、大血藤、车前子、茯苓、牛膝、五味子。结论:运用中药治疗慢性前列腺炎以疏肝理气、散结止痛、活血祛瘀为主,兼以利尿通淋,在临床上辨证施治用药拓展了治疗思路。Objective: Exploring the prescription rules of traditional Chinese medicine for the treatment of chronic prostatitis based on data mining methods. Method: Collect traditional Chinese medicine prescriptions from 219 patients with chronic prostatitis in the male outpatient department of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from May 2023 to June 2024. Based on the V2.3.5 ancient and modern medical case cloud platform, analyze the medication prescription rules through data mining methods. Results: A total of 122 effective prescriptions for the treatment of chronic prostatitis were included, including 264 traditional Chinese medicines. The top 5 drugs with the highest frequency of use are orange kernel, Melia azedarach L. seed, peach kernel, kelp, and seaweed;the main medicinal properties are mild, warm, and sweet;the medicinal taste is mainly bitter and salty;the main meridians for medication are the liver meridian, kidney meridian, and stomach meridian;the top three effects of frequent use are soothing the liver and regulating qi, dispersing nodules and relieving pain, and promoting blood circulation and removing blood stasis. The analysis of drug association rules shows that the top three in terms of support are “orange kernel, Melia azedarach L. seed”, “Melia azedarach L. seed, peach kernel”, and “orange kernel, peach kernel”. Through cluster analysis, a total of three cluster combinations were obtained, with cluster 1 being orange kernel, Melia azedarach L. seed, peach kernel, kelp, and seaweed;Cluster 2 includes Poria cocos, Schisandra chinensis, Angelica sinensis, and Bupleurum chinense;Cluster 3 consists of Scutellaria baicalensis, Plantago asiatica, green peel, Achyranthes bidentata, Fructus Aurantii Immaturus, and Lychee seeds. The core drugs of the 122 effective prescriptions are orange kernel, Melia azedarach L. seed, peach kernel, green peel, kelp, seaweed, Fructus Aurantii, lychee kernel, Scutellaria baicalensis, Plantago asiatica, Poria cocos, Achyranthes bidentata, and Schisandra chinensis. Conclusion: The use of traditional Chinese medicine in the treatment of chronic prostatitis mainly focuses on soothing the liver and regulating qi, dispersing nodules and relieving pain, promoting blood circulation and removing blood stasis, while also promoting diuresis and clearing the lymphatic system. In clinical practice, the use of medication based on syndrome differentiation has expanded the treatment approach.
