膜性肾病是临床上较为常见的慢性肾小球疾病病理类型,分为特发性膜性肾病和继发性膜性肾病,病理特征是免疫复合物的沉积导致肾小球基底膜增厚。该疾病病理机制较为复杂,目前尚不明确。近年来,随着肾活检人数的增加,膜性肾病的发病率也...膜性肾病是临床上较为常见的慢性肾小球疾病病理类型,分为特发性膜性肾病和继发性膜性肾病,病理特征是免疫复合物的沉积导致肾小球基底膜增厚。该疾病病理机制较为复杂,目前尚不明确。近年来,随着肾活检人数的增加,膜性肾病的发病率也呈上升趋势。任何年龄段均可发作,但大多数患者年龄集中在40~60岁之间,男性比女性更多见。约30%的患者临床症状会伴有镜下血尿,一般无肉眼血尿。本文拟对近来膜性肾病的临床治疗方案新认识做一综述。Membranous nephropathy is a common pathological type of chronic glomerular disease in clinical practice, divided into idiopathic membranous nephropathy and secondary membranous nephropathy. The pathological feature is the deposition of immune complexes leading to thickening of the glomerular basement membrane. The pathological mechanism of this disease is relatively complex and currently unclear. In recent years, with the increase of the number of renal biopsy, the incidence rate of membranous nephropathy is also on the rise. It can occur at any age, but most patients are concentrated between the ages of 40~60, with males more common than females. About 30% of patients have clinical symptoms accompanied by microscopic hematuria, generally without gross hematuria. This article aims to review the new understanding of recent clinical treatment strategies for membranous nephropathy.展开更多
贫血是慢性肾脏病(CKD)的主要并发症,也是心血管事件和生活质量低下(QoL)的风险因素。而糖尿病肾病(DKD)是导致CKD的主要原因,且DKD相关性贫血发生更早、更严重,其机制更为复杂。本文就慢性肾脏病贫血管理指南及相关研究,综述糖尿病肾...贫血是慢性肾脏病(CKD)的主要并发症,也是心血管事件和生活质量低下(QoL)的风险因素。而糖尿病肾病(DKD)是导致CKD的主要原因,且DKD相关性贫血发生更早、更严重,其机制更为复杂。本文就慢性肾脏病贫血管理指南及相关研究,综述糖尿病肾病贫血的发生机制及治疗进展。Anemia is a major complication of chronic kidney disease (CKD) and a risk factor for cardiovascular events and poor quality of life (QoL). In contrast, diabetic kidney disease (DKD) is the main cause of CKD, and DKD-associated anemia occurs earlier, is more severe, and its mechanisms are more complex. In this article, we review the mechanism of anemia in diabetic kidney disease and the progress of treatment with regard to the guidelines for anemia management in chronic kidney disease and related studies.展开更多
近年来,慢性肾脏病的患病人数逐渐升高,心血管疾病是慢性肾脏病最常见并发症及首要死亡原因,给人类健康带来了很大威胁。除了高血脂、糖尿病等传统危险因素外,贫血、钙磷代谢失调、炎症等对心血管意外的发生也有一定的影响。单核细胞数...近年来,慢性肾脏病的患病人数逐渐升高,心血管疾病是慢性肾脏病最常见并发症及首要死亡原因,给人类健康带来了很大威胁。除了高血脂、糖尿病等传统危险因素外,贫血、钙磷代谢失调、炎症等对心血管意外的发生也有一定的影响。单核细胞数与高密度脂蛋白胆固醇比值(MHR)是反映炎症和氧化应激的一项新指标。本文将对MHR对慢性肾病心血管并发症的相关研究进行综述。In recent years, the number of people with chronic kidney disease (CKD) has gradually increased, and cardiovascular disease is the most common complication and leading cause of death from CKD, which poses a great threat to human health. In addition to traditional risk factors such as hyperlipidemia, diabetes, etc., anemia, calcium and phosphorus metabolism disorders, and inflammation also have a certain impact on the occurrence of cardiovascular accidents. The ratio of monocyte count to HDL cholesterol (MHR) is a novel indicator of response to inflammation and oxidative stress. This article will review the relevant studies on the effects of MHR on cardiovascular complications of chronic kidney disease.展开更多
文摘膜性肾病是临床上较为常见的慢性肾小球疾病病理类型,分为特发性膜性肾病和继发性膜性肾病,病理特征是免疫复合物的沉积导致肾小球基底膜增厚。该疾病病理机制较为复杂,目前尚不明确。近年来,随着肾活检人数的增加,膜性肾病的发病率也呈上升趋势。任何年龄段均可发作,但大多数患者年龄集中在40~60岁之间,男性比女性更多见。约30%的患者临床症状会伴有镜下血尿,一般无肉眼血尿。本文拟对近来膜性肾病的临床治疗方案新认识做一综述。Membranous nephropathy is a common pathological type of chronic glomerular disease in clinical practice, divided into idiopathic membranous nephropathy and secondary membranous nephropathy. The pathological feature is the deposition of immune complexes leading to thickening of the glomerular basement membrane. The pathological mechanism of this disease is relatively complex and currently unclear. In recent years, with the increase of the number of renal biopsy, the incidence rate of membranous nephropathy is also on the rise. It can occur at any age, but most patients are concentrated between the ages of 40~60, with males more common than females. About 30% of patients have clinical symptoms accompanied by microscopic hematuria, generally without gross hematuria. This article aims to review the new understanding of recent clinical treatment strategies for membranous nephropathy.
文摘贫血是慢性肾脏病(CKD)的主要并发症,也是心血管事件和生活质量低下(QoL)的风险因素。而糖尿病肾病(DKD)是导致CKD的主要原因,且DKD相关性贫血发生更早、更严重,其机制更为复杂。本文就慢性肾脏病贫血管理指南及相关研究,综述糖尿病肾病贫血的发生机制及治疗进展。Anemia is a major complication of chronic kidney disease (CKD) and a risk factor for cardiovascular events and poor quality of life (QoL). In contrast, diabetic kidney disease (DKD) is the main cause of CKD, and DKD-associated anemia occurs earlier, is more severe, and its mechanisms are more complex. In this article, we review the mechanism of anemia in diabetic kidney disease and the progress of treatment with regard to the guidelines for anemia management in chronic kidney disease and related studies.
文摘近年来,慢性肾脏病的患病人数逐渐升高,心血管疾病是慢性肾脏病最常见并发症及首要死亡原因,给人类健康带来了很大威胁。除了高血脂、糖尿病等传统危险因素外,贫血、钙磷代谢失调、炎症等对心血管意外的发生也有一定的影响。单核细胞数与高密度脂蛋白胆固醇比值(MHR)是反映炎症和氧化应激的一项新指标。本文将对MHR对慢性肾病心血管并发症的相关研究进行综述。In recent years, the number of people with chronic kidney disease (CKD) has gradually increased, and cardiovascular disease is the most common complication and leading cause of death from CKD, which poses a great threat to human health. In addition to traditional risk factors such as hyperlipidemia, diabetes, etc., anemia, calcium and phosphorus metabolism disorders, and inflammation also have a certain impact on the occurrence of cardiovascular accidents. The ratio of monocyte count to HDL cholesterol (MHR) is a novel indicator of response to inflammation and oxidative stress. This article will review the relevant studies on the effects of MHR on cardiovascular complications of chronic kidney disease.
