目的:克罗恩病和痛风发病率逐年增高,但其关联性尚未明确。本研究利用孟德尔随机化方法,探讨克罗恩病与痛风之间的潜在因果关系。方法:我们选取与克罗恩病和痛风显著关联的单核苷酸多态性作为工具变量,利用公开的全基因组关联研究的汇...目的:克罗恩病和痛风发病率逐年增高,但其关联性尚未明确。本研究利用孟德尔随机化方法,探讨克罗恩病与痛风之间的潜在因果关系。方法:我们选取与克罗恩病和痛风显著关联的单核苷酸多态性作为工具变量,利用公开的全基因组关联研究的汇总统计数据进行分析。我们采用多种MR方法并进行了敏感性分析。结果:克罗恩病与痛风的发病风险正相关(OR = 1.00060493,95%置信区间1.00013013~1.00107996,P值 = 0.01251316)。敏感性分析进一步印证了该发现,未见明显的异质性和水平多效性。结论:我们的研究结果表明克罗恩病与痛风之间存在正相关关系。这一发现为克罗恩病与痛风之间的关系及其病理生理机制提供了新的见解,并为痛风的预防和治疗提出了新策略。Objective: The incidence of Crohn’s disease and gout is increasing year by year, but the correlation is not clear, so we conducted a two-sample bidirectional mendelian randomization study to examine the association between them. Method: We selected single nucleotide polymorphisms significantly associated with Crohn’s disease and gout as instrumental variables and analyzed them using summary statistics from publicly available genome-wide association studies. We used multiple MR methods and performed sensitivity analyses. Results: The results revealed that Crohn’s disease was positively associated with the risk of developing gout (Odds Ratio, OR = 1.00060493, 95% Confidence Interval, CI, 1.00013013~1.00107996, P value = 0.01251316). Sensitivity analyses further corroborated the finding, with no significant heterogeneity or horizontal pleiotropy seen. Conclusions: Our findings suggest a positive association between Crohn’s disease and gout. This finding provides new insights into the relationship between Crohn’s disease and gout and its pathophysiologic mechanisms, and new strategies for the prevention and treatment of gout.展开更多
文摘目的:克罗恩病和痛风发病率逐年增高,但其关联性尚未明确。本研究利用孟德尔随机化方法,探讨克罗恩病与痛风之间的潜在因果关系。方法:我们选取与克罗恩病和痛风显著关联的单核苷酸多态性作为工具变量,利用公开的全基因组关联研究的汇总统计数据进行分析。我们采用多种MR方法并进行了敏感性分析。结果:克罗恩病与痛风的发病风险正相关(OR = 1.00060493,95%置信区间1.00013013~1.00107996,P值 = 0.01251316)。敏感性分析进一步印证了该发现,未见明显的异质性和水平多效性。结论:我们的研究结果表明克罗恩病与痛风之间存在正相关关系。这一发现为克罗恩病与痛风之间的关系及其病理生理机制提供了新的见解,并为痛风的预防和治疗提出了新策略。Objective: The incidence of Crohn’s disease and gout is increasing year by year, but the correlation is not clear, so we conducted a two-sample bidirectional mendelian randomization study to examine the association between them. Method: We selected single nucleotide polymorphisms significantly associated with Crohn’s disease and gout as instrumental variables and analyzed them using summary statistics from publicly available genome-wide association studies. We used multiple MR methods and performed sensitivity analyses. Results: The results revealed that Crohn’s disease was positively associated with the risk of developing gout (Odds Ratio, OR = 1.00060493, 95% Confidence Interval, CI, 1.00013013~1.00107996, P value = 0.01251316). Sensitivity analyses further corroborated the finding, with no significant heterogeneity or horizontal pleiotropy seen. Conclusions: Our findings suggest a positive association between Crohn’s disease and gout. This finding provides new insights into the relationship between Crohn’s disease and gout and its pathophysiologic mechanisms, and new strategies for the prevention and treatment of gout.
